Ameliorative potential of Vigna mungo seeds on hyperglycemia mediated oxidative stress and hyperlipidemia in STZ diabetic rats

Abstract

Ethnomedicinally the seeds of Vigna mungo are used as cooling astringent, diet during fever, poultice for abscesses, soap alternative. The increased oxidative stress plays an important role in the etiology and pathogenesis of diabetes mellitus and its various complications. This study was designed to examine the effect of hydroalcoholic extract (VME) of V. mungo seeds on STZ-diabetic rats by measuring glycemia, lipid profile, and lipid peroxidation parameters (MDA, PCO, and GSH) and antioxidant enzymes activities (SOD, CAT, and GPx). The levels of glucose, TG, TC, MDA, and PCO were increased significantly whereas the levels of serum insulin, reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and Glutathione peroxidise (GPx) were decreased in STZ induced diabetic rats. Administration of VME (200 mg/kg bw and 400 mg/kg bw p.o.) to diabetic rats for 28 days showed a significant decrease in serum glucose, TG, TC, MDA, and PCO. In addition, we also summarize here that the levels of serum insulin, superoxide dismutase, catalase, GPx, and reduced glutathione (GSH) were increased in VME treated diabetic rats. The antioxidant and antihyperglycemic effect of VME was compared with glibenclamide, a well-known antioxidant and antihyperglycemic drug. The findings in this study suggest that the VME possesses a significant favourable effect on antioxidant defense system in addition to its antidiabetic effect. Nonetheless, this study provides evidence that could help explain how the traditional use of V. mungo has been successful in the treatment of various disorders in humans.

Preventive and Curative Potential of Vigna mungo against Metabolic Syndrome in Acute and Chronic Rat Models

“…For example, popular drugs like atorvastatin has serious side effect such as myopathy (Moosmann and Behl, 2004), whereas, pioglitazone can cause bone loss (Shah and Mudaliar, 2010). Because of this, new natural medicinal agents with properties on monitoring both lipids and blood glucose are in excessive demand (Nammi et al, 2009).The extract of V. mungo (VME) having low glycemic index and high fibre content is helpful in the treatment of obesity and type 2 diabetes (Meenu et al, 2011). Vigna mungo directly acts on the α amylase protein inhibitors and is used in prevention of obesity (Koshiba and Minamikawa, 1983).…”

“…These constituents can be very beneficial in faster removal of free fatty acids from circulation, which causes a reduction in total cholesterol by increasing the lipoprotein lipase activity (Solanki and Jain, 2010). The extract of V. mungo (VME) having low glycemic index and high fibre content is helpful in the treatment of obesity and type 2 diabetes (Meenu et al, 2011).…”

Targeted HPTLC Profile, Quantification of Flavonoids and Phenolic Acids, and Antimicrobial Activity of Dodonaea angustifolia (L.f.) Leaves and Flowers

“…In Latin America, China, Africa, and India, D. angustifolia aerial parts are used as a traditional medicine to treat fevers, swellings, and colds [ 5 , 6 ]. Roundworms and trachoma are both treated with powdered leaf juice [ 7 ].…”

“…The root’s antidiarrheal properties have been demonstrated by the root’s alcohol and aqueous extract, which greatly reduced diarrhea in mice and resulted in lighter feces [ 14 ]. The leaves showed analgesic [ 7 ], antidiabetic [ 6 , 15 , 16 , 17 ], anti-inflammatory [ 18 , 19 ], antioxidant [ 20 , 21 ], antipyretic [ 22 ], antiviral [ 23 , 24 ], hypotensive [ 7 ], and wound healing [ 25 ] properties. There is evidence that D. angustifolia has the potential to be an allelopathic plant, as extracts of this plant can inhibit the germination and growth of other plants [ 26 , 27 , 28 ].…”

Regeneration of pancreatic β-cells on streptozotocin induced diabetic rats under the effect of Swietenia macrophylla seeds

“…The use of herbal medicines has been steadily increasing over the past decade. Several medicinal plants which have been traditionally used in the treatment of different disease including diabetes mellitus, cancer, liver disease and cardiac ailments [1,2] etc., are now gaining attraction by researchers all over the world for scientific analysis. A considerable number of these plant based products are presently in use.…”