Ameliorative impact of Morus alba leaves’ aqueous extract against embryonic ophthalmic tissue malformation in streptozotocin-induced diabetic rats

Assiri, Adel M. A.; El‐Beeh, Mohamed E.; Amin, Ali H.; Ramadan, Mohamed Fawzy

doi:10.1016/j.biopha.2017.09.013

Cited by 20 publications

(12 citation statements)

References 69 publications

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“…DM is one of the most serious disorders threatening human health (Assiri et al, ; Esteves et al, ; Hebi et al, ; Wang et al, ). DM is characterized by the dysfunction of islet cells that resulted in lower secretion of insulin from pancreatic β‐cells or no response to the insulin.…”

Section: Discussionmentioning

confidence: 99%

“…DM is one of the most serious disorders threatening human health (Assiri et al, 2017;Esteves et al, 2008;Hebi et al, 2017;Wang et al, 2018). DM is characterized by the dysfunction of islet cells however, the outcome is still not satisfactory (Wang et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…Approval from the Research Ethics Committee at Mansoura University (Egypt) was obtained before the experiment. Animals were housed in 20–25°C temperature, 45%–60% humidity, and 12 hr light/dark conditions (Assiri et al, ). The protective dose of RO was 100 mg/kg b.w.…”

Section: Methodsmentioning

confidence: 99%

“…T2DM covers 90%–95% of the cases and is considered the main endocrine disorder worldwide (Gulçin et al, ; Taslimi et al, ). Pathogenesis and classification of T2DM involve an abnormality in lipid metabolism and glucose, resistance to insulin activities, and inadequate insulin secretion from the β‐cells (Achenbach, Bonifacio, Koczwara, & Ziegler, ; Assiri et al, ; Goldstein, ). Oxidative stress has a great responsibility in the DM pathogeneses, which is associated with dysfunction of male reproduction (Ballester et al, ; Baynes & Thorpe, ).…”

Section: Introductionmentioning

confidence: 99%

“…Worldwide, diabetes mellitus (DM) is the main fast-growing chronic diseases. The World Health Organization (WHO) estimated that patients with DM will reach 300 million by 2025 (Assiri, El-Beeh, Amin, & Ramadan, 2017;Jeszka-Skowron et al, 2014;Rahimi-Madiseh, Heidarian, Kheiri, & Rafieian-Kopaei, 2017;Sarfraz, Khaliq, Khan, & Aslam, 2017). DM is categorized as type 1 (T1DM) and type 2 (T2DM).…”

Section: Introductionmentioning

confidence: 99%

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Ameliorative impact of cold‐pressedRosmarinus officinalisoil against liver toxicity and genotoxic effects in streptozotocin‐induced diabetic rats and their offspring

et al. 2019

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Diabetes mellitus (DM) is a chronic, lifelong condition threatening human health. Rosmarinus officinalis oil (RO) could have a future role in DM therapy. This study evaluated the composition and antioxidative potential of RO. Antidiabetic traits of RO in streptozotocin (STZ)‐induced diabetic rats was also studied considering the ameliorative impact against embryogenesis defects using in vitro and in vivo biochemical, histological, and genetic assays. RO was investigated for fatty acids and bioactive compounds (tocols and total phenolic compounds), and antiradical potential against DPPH• radicals. The genetic effects were investigated using comet assay and DNA fragmentation test. DM was induced to albino rats by injecting 60 mg/kg of STZ, while RO (100 mg/kg b.w.) was administered. The pregnant animals were divided into four groups; control (C), RO‐treated (RO), diabetic (D), and combined diabetic with RO‐treated (D‐RO). The study was conducted for 180 days. In RO, the contents of polyunsaturated fatty acids, monounsaturated fatty acids, and saturated fatty acids were 42.3%, 41.7%, and 15.8%, respectively. The levels of α‐, β‐, γ‐, and δ‐tocopherols were 280, 20, 1,025, and 35 mg/100 g RO, respectively. RO contained 7.2 mg GAE/g of total phenolic compounds (TPC), while RO quenched 70% of DPPH• radicals. While glucose levels reached the highest in DM rats, treating STZ‐induced diabetic animals with RO‐resoluted serum glucose levels. RO reduced the highest levels of serum chemistry parameters were recorded in DM animals. Histological photographs of maternal and fetus liver exhibited degenerated hepatic cells and congestion central vein. Comet cells and DNA fragments were significantly decreased in D‐RO group comparing to the DM group. RO exhibited antidiabetic capabilities, and thus, it could be utilized as a functional ingredient in novel foods, nutraceuticals, and dietary supplements for diabetic patients. Practical applications RO is rich in bioactive phytochemicals (tocols and phenolic compounds) with antiradical and antihyperglycemic capabilities. Tocols and phenolics are active in radical scavenging of reactive nitrogen species (i.e., peroxynitrite and nitrogen dioxide), and in the prevention of DNA bases nitration. Our results demonstrated that RO could improve the disturbed metabolism of carbohydrate in STZ‐diabetic animals. The potential mode of action of bioactive compounds in RO most likely encompasses the intracellular pathway involved in glucose homeostasis or insulin signaling. In addition, the suppression of oxidative stress by phenolic compounds could provide to the antidiabetic impacts of RO. Our data supported that RO could be utilized to ameliorate DM. Protection with RO directed high protection of the maternal organs and offspring against the oxidative stress of diabetes due to the antihyperlipidemic effects and the antioxidant capabilities of RO.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ameliorative impact of cold‐pressedRosmarinus officinalisoil against liver toxicity and genotoxic effects in streptozotocin‐induced diabetic rats and their offspring

et al. 2019

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Morus alba: a comprehensive phytochemical and pharmacological review

Batiha

Al-Snafi

Thuwaini

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Morusalba is a fast-growing shrub or medium-sized tree with a straight, cylindrical trunk. Medicinally, whole plants, leaves, fruits, branches, and roots have been employed. Google Scholar, PubMed, Scopus, and Web of Science were used to search for relevant material on the phytochemical components and pharmacologic and mechanism of action of the Morus alba. This was reviewed to assess important updates about Morus alba. The fruits of Morus alba have traditionally been used as an analgesic, anthelmintic, antibacterial, anti-rheumatic, diuretic, hypotensive, hypoglycemia, purgative, restorative, sedative tonic, and blood stimulant. Various plant parts were used as a cooling, sedating, diuretic, tonic, and astringent agent to treat nerve disorders. The plant contained tannins, steroids, phytosterols, sitosterol, glycosides, alkaloids, carbohydrates, proteins, and amino acids, as well as saponins, triterpenes, phenolics, flavonoids, benzofuran derivatives, anthocyanins, anthraquinones, glycosides, vitamins, and minerals. Previous pharmacological research identified antimicrobial, anti-inflammatory, immunological, analgesic, antipyretic, antioxidant, anti-cancer, antidiabetic, gastrointestinal, respiratory, cardiovascular, hypolipidemic, anti-obesity, dermatological, neurological, muscular, and protecting effects. This study looked at Morus alba’s traditional uses, chemical components, and pharmacological effects.

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Ameliorative effects of Carica papaya extracts against type II diabetes-induced myocardial pathology and dysfunction in albino rats.

Amin

2021

Environ Sci Pollut Res

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Ameliorative impact of Morus alba leaves’ aqueous extract against embryonic ophthalmic tissue malformation in streptozotocin-induced diabetic rats

Cited by 20 publications

References 69 publications

Ameliorative impact of cold‐pressedRosmarinus officinalisoil against liver toxicity and genotoxic effects in streptozotocin‐induced diabetic rats and their offspring

Ameliorative impact of cold‐pressedRosmarinus officinalisoil against liver toxicity and genotoxic effects in streptozotocin‐induced diabetic rats and their offspring

Morus alba: a comprehensive phytochemical and pharmacological review

Ameliorative effects of Carica papaya extracts against type II diabetes-induced myocardial pathology and dysfunction in albino rats.

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