Ameliorative effect of gossypin against gentamicin-induced nephrotoxicity in rats

Mohamed, Dareen Abd El-Aziz; Salahuddin, A

doi:10.1016/j.lfs.2017.03.009

Cited by 27 publications

(26 citation statements)

References 30 publications

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“…The results offered by a published study expressed that GA (20 mg/kg, for seven days) isolated from Peltiphyllum peltatum mitigated the serum levels of urea, Cr, uric acid, and blood urea nitrogen (BUN) in rats with NaF induced nephrotoxicity [41]. Moreover, the findings of our study have confirmed previous researches on the effects of other antioxidants in ameliorating kidney damages due to GM that can refer to aminoguanidine [42], gossypin [43], and nigella sativa [44]. Therefore, the protective roles of GA in reducing the levels of renal function markers and histopathological changes may be associated with its antioxidant activities, as reported in the present study and above-mentioned previous studies.…”

Section: Discussionsupporting

confidence: 88%

Renoprotective Effects of Gallic Acid Against Gentamicin Nephrotoxicity Through Amelioration of Oxidative Stress in Rats

Ahmadvand

Nouryazdan

Nasri

et al. 2020

Braz. arch. biol. technol.

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Gallic acid (GA), as a strong antioxidant, was selected in this study to investigate its possible nephroprotective effects against gentamicin (GM)-induced nephrotoxicity. Twenty-four rats were separated into three groups (n=8): group 1 (control group) received saline (0.5 mL/day), group 2 (GM group) received GM (100 mg/kg/day), and group 3 (treated group) received GM (100 mg/kg/day) and GA (100mg/kg/day). All treatments were performed intraperitoneally for 12 days. After 12 days, the rats were euthanized, and kidneys were removed immediately. For serum preparation, blood samples were collected before killing. Kidney paraffin sections were prepared from one of the kidneys and stained by the periodic acid-Schiff process. GA significantly decreased GM-induced renal histopathological injuries, including tubular necrosis, tubular cast, and leucocyte infiltration compared with the GM group. Additionally, GA significantly improved proteinuria, serum levels of urea and creatinine, and serum activities of aspartate aminotransferase (AST) and alanine HIGHLIGHTS  Gallic acid ameliorates gentamicin-induced nephrotoxicity.  Gallic acid decreases levels of NO and MDA and enhances abilities of GSH, GPX, and CAT.  Gallic acid improves altered liver and renal function markers in nephrotoxic animals.  Gallic acid reduces renal histopathological injuries.  2 Ahmadvand, H.; et al.

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Section: Discussionsupporting

confidence: 88%

Renoprotective Effects of Gallic Acid Against Gentamicin Nephrotoxicity Through Amelioration of Oxidative Stress in Rats

Ahmadvand

Nouryazdan

Nasri

et al. 2020

Braz. arch. biol. technol.

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“…Concordant with previous literatures, 26,27 the current study demonstrated several histological and ultrastructural changes along with significant deterioration of renal functions upon GM administration. On the other hand, vitamin D prevented most of these functional and histological disturbances.…”

Section: Discussionsupporting

confidence: 92%

Vitamin D attenuates gentamicin-induced acute renal damage via prevention of oxidative stress and DNA damage

2018

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Background: Despite being one of the most nephrotoxic drugs, gentamicin (GM) remains a mainstay as a first-choice agent in a vast variety of clinical situations owing to its superlative efficiency as a broad-spectrum antibiotic in treating several life-threatening bacterial infections. This urgently calls for the need for in-depth analysis of the mechanisms governing GM-induced nephrotoxicity and entails the necessity of presenting novel protective agents capable of ameliorating those renal deleterious effects. The reactive oxygen species and redox-sensitive transcription factors in GM-induced nephrotoxicity have recently called attention. Purpose: This study has been designed to shed light on the possible mechanisms of GM-induced nephrotoxicity and to provide a consensus set of histopathological, immunohistochemical, genetic and biochemical parameters elucidating the protective role of vitamin D against this nephrotoxicity. Methods: Twenty-four adult male albino rats were equally divided into four groups: group I (control group), group II (GM), group III (GM + vitamin D) and group IV (vitamin D only). Kidney function tests, histopathological examination, gene expression of nuclear factor 2, nuclear factor kappa beta (NF-κB) and western blot of NF-κB p65, assessment of glutathione peroxidase and nicotinamide adenine dinucleotide phosphate oxidase (NADPH) oxidase by ELISA, as well as immunohistochemical evaluation of inducible nitric oxide, malondialdehyde, 8-hydroxy 2 deoxyguanine and vitamin D receptor, have been carried out. Results: The kidney function deterioration, tissue oxidative stress development and the histopathological changes induced by GM were significantly attenuated by vitamin D administration. Conclusion: Vitamin D attenuates GM nephrotoxicity through its antioxidant properties and prevention of DNA damage.

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“…In our experiment this finding was interpreted by the study of Toubeau et al [27] who stated that gentamicin could access the distal tubules with longer treatment period. Some areas of the renal cortex showed mononuclear cellular infiltration which was compatible with Katary and Salahuddin [28] who investigated the important role of the inflammation in gentamicin-induced renal injury and signified the elevated levels of inflammatory cytokines IL-6 and TNF-α besides their mRNA synthesis. Gentamicin is known to greatly reduce the level of NF-κB inhibitor (IkB-α) protein resulting in stimulation of inflammatory cytokines; TNF-α and IL-6 synthesis [29].…”

Section: Discussionsupporting

confidence: 80%

Amelioration of renal cortex histological alterations by aqueous garlic extract in gentamicin induced renal toxicity in albino rats: a histological and immunohistochemical study

Mohamed

Shenouda

2021

Alexandria Journal of Medicine

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Background: Aminoglycosides, particularly gentamicin, endure crucial antibiotics in the armamentarium for severe Gram-negative bacterial infections through their significant risk for nephrotoxicity. Co-administration of several applicant nephroprotective agents has been investigated at the preclinical level. Garlic was proved to be an oxidative stress combatant with unique antioxidant potential. Aim of the work:To assess renal cortex structural changes due to gentamicin treatment and the role of the aqueous garlic extract (AGE) in ameliorating these changes. Material and methods: Thirty-two male albino rats were assigned into four equal groups. Group I (Control group) received 0.9% NaCl solution through oral gavage in the same volume as in AGE-treated group. Group II (AGE treated group) received AGE by oral gavage at 250 mg/ kg/day. Group III (Gentamicin treated group) received Gentamicin at 80 mg/kg/day intraperitoneally. Group IV (Gentamicin and AGE cotreated group) received both gentamicin and AGE. The duration of the treatment was 21 days. Specimens of renal cortex of all groups were processed for light microscopic examination. Specimens were additionally prepared for electron microscopic examination. Morphometric study and statistical analysis were performed. Results: Examination of the renal cortex in the gentamicin treated rats showed both proximal and distal tubular necrosis, vacuolation, desquamation and interstitial mononuclear cell infiltration. Masson's trichrome staining revealed intense deposition of collagen fibers. Strong positive immunoreaction for caspase-3 was observed. Ultrastructurally, the glomerulus showed thickened basement membrane, destructed endothelium. Proximal and distal convoluted tubular cells exhibited vacuolations, distorted mitochondria and nuclear chromatin condensation with loss of microvilli. AGE ameliorated these changes. Conclusion: Aqueous garlic extract ameliorates the histological changes caused by gentamicin in the rat renal cortex.

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Ameliorative effect of gossypin against gentamicin-induced nephrotoxicity in rats

Cited by 27 publications

References 30 publications

Renoprotective Effects of Gallic Acid Against Gentamicin Nephrotoxicity Through Amelioration of Oxidative Stress in Rats

Renoprotective Effects of Gallic Acid Against Gentamicin Nephrotoxicity Through Amelioration of Oxidative Stress in Rats

Vitamin D attenuates gentamicin-induced acute renal damage via prevention of oxidative stress and DNA damage

Amelioration of renal cortex histological alterations by aqueous garlic extract in gentamicin induced renal toxicity in albino rats: a histological and immunohistochemical study

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