Amelioration of genotoxic damage by certain phytoproducts in human lymphocyte cultures

Ahmad, Sharique; Sheeba,; Afzal, Mohammad

doi:10.1016/j.cbi.2004.06.008

Cited by 25 publications

(12 citation statements)

References 23 publications

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“…Curcumin has protective effect against cisplatin (Antunes et al, 2000), hydrocortisone (Ahmad et al, 2004), nicotine (Kalpana and Menon, 2004) (El-Ashmawy et al, 2006), ethanol (Naik et al, 2004) and irradiation (Thresiamma et al, 1998) induced damage in in vivo and in vitro test systems. Furthermore it has antimutagenic potential against cyclophosphamide and BAP induced genotoxicity in microbial and mammalian test systems (Shukla et al, 2002;.…”

Section: Introductionmentioning

confidence: 99%

Antimutagenic potential of curcumin on chromosomal aberrations in Allium cepa

Ragunathan

Panneerselvam²

2007

J. Zhejiang Univ. - Sci. B

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Abstract:Turmeric has long been used as a spice and food colouring agent in Asia. In the present investigation, the antimutagenic potential of curcumin was evaluated in Allium cepa root meristem cells. So far there is no report on the biological properties of curcumin in plant test systems. The root tip cells were treated with sodium azide at 200 and 300 µg/ml for 3 h and curcumin was given at 5, 10 and 20 µg/ml for 16 h, prior to sodium azide treatment. The tips were squashed after colchicine treatment and the cells were analyzed for chromosome aberration and mitotic index. Curcumin induces chromosomal aberration in Allium cepa root tip cells in an insignificant manner, when compared with untreated control. Sodium azide alone induces chromosomal aberrations significantly with increasing concentrations. The total number of aberrations was significantly reduced in root tip cells pretreated with curcumin. The study reveals that curcumin has antimutagenic potential against sodium azide induced chromosomal aberrations in Allium cepa root meristem cells. In addition, it showed mild cytotoxicity by reducing the percentage of mitotic index in all curcumin treated groups, but the mechanism of action remains unknown. The antimutagenic potential of curcumin is effective at 5 µg/ml in Allium cepa root meristem cells.

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Section: Introductionmentioning

confidence: 99%

Antimutagenic potential of curcumin on chromosomal aberrations in Allium cepa

Ragunathan

Panneerselvam²

2007

J. Zhejiang Univ. - Sci. B

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“…In this present study, Turmeric extract showed drastic reduction of chromatid breaks, chromosome gaps, breaks, fragments and exchanges when compared with the corresponding positive and negative controls. Curcumin showed anti-mutagenic, anti-genotoxic and protective effects on various test systems [21][22][23][24][25][26][27]. Curcumin, as a free radical scavenger has anti-clastogenic property [23].…”

Section: Discussionmentioning

confidence: 99%

“…Curcumin showed anti-mutagenic, anti-genotoxic and protective effects on various test systems [21][22][23][24][25][26][27]. Curcumin, as a free radical scavenger has anti-clastogenic property [23]. It protects the genome from radiation-induced damages in DNA [24].…”

Section: Discussionmentioning

confidence: 99%

An Evaluation of Anti-Clastogenic Activities for Garlic (Allium Sativum), Turmeric (Curcuma Longa) and Tulsi (Ocimum Tenuiflorum) with Clastogen (Mitomycin) in Human Lymphocytes – A Case Study

2020

JCRC

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Chromosomal aberrations based human syndrome are very critical and sometimes leads to lethality. Such syndrome or disorders are often irreversible. In this present study, we evaluated the preventing effect of herbal extracts from Ocimum (tulsi), Curcuma (turmeric) and Allium (garlic) in developing chromosomal aberrations in whole blood human lymphocytes. The results showed that the clastogenic effect was minimised by the combination of all three herbal extracts compared to the individual extract effects. The spontaneous chromosomal aberrations caused in lymphoma cells were also minimized by the herbal extracts.

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“…Prolonged use of oral contraceptives has been reported to induce different types of cancer in both animals and humans [19][20][21][22]. The use of synthetic progestins cannot be completely eliminated, but their genotoxic effects can be reduced by the use of antioxidants [23,24] and natural plant products [25][26][27]. CMA induces genotoxic effects by the generation of reactive oxygen species (ROS) in human lymphocytes in vitro [15].…”

Section: Discussionmentioning

confidence: 99%

Antigenotoxic effect of nordihydroguaiaretic acid against chlormadinone acetate-induced genotoxicity in mice bone-marrow cells

et al. 2007

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Nordihydroguaiaretic acid (NDGA), a phenolic lignan, was tested for its antigenotoxic potential against chlormadinone acetate (CMA)-induced genotoxic damage in mice bone-marrow cells. Doses of about 22.50 mg/kg body weight of CMA were given along with 1, 5 and 10 mg/kg body weight of NDGA intraperitoneally. The treatment resulted in the reduction of sister chromatid exchanges and chromosomal aberrations induced by CMA, suggesting an antigenotoxic potential of NDGA. Earlier studies show that CMA generates reactive oxygen species, responsible for genotoxic damage. The free radical-scavenging property of NDGA is responsible for the reduction of genotoxic damage induced by CMA in mice bone-marrow cells.

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Amelioration of genotoxic damage by certain phytoproducts in human lymphocyte cultures

Cited by 25 publications

References 23 publications

Antimutagenic potential of curcumin on chromosomal aberrations in Allium cepa

Antimutagenic potential of curcumin on chromosomal aberrations in Allium cepa

An Evaluation of Anti-Clastogenic Activities for Garlic (Allium Sativum), Turmeric (Curcuma Longa) and Tulsi (Ocimum Tenuiflorum) with Clastogen (Mitomycin) in Human Lymphocytes – A Case Study

Antigenotoxic effect of nordihydroguaiaretic acid against chlormadinone acetate-induced genotoxicity in mice bone-marrow cells

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