Alveolar Ridge and Sinus Augmentation Utilizing Platelet‐Rich Plasma in Combination With Freeze‐Dried Bone Allograft: Case Series

Abstract

These clinical and histological findings suggest that ridge augmentation and sinus grafting with FDBA in combination with PRP provide a viable therapeutic alternative for implant placements. Future studies are necessary to determine whether PRP enhances new bone formation or maturation with bone replacement allografts.

Spinal fusion using an autologous growth factor gel and a porous resorbable ceramic

“…The biological and mechanical effects of such treatments remain to be completely characterised. The isolation of platelet-rich plasma is by no means a new idea [32,37,40]. This concept has been recently reintroduced in alveolar bone regeneration [1,32] and bone grafts [34].…”

“…The isolation of platelet-rich plasma is by no means a new idea [32,37,40]. This concept has been recently reintroduced in alveolar bone regeneration [1,32] and bone grafts [34]. Platelet-rich plasma has also been used as an autologous source of a fibrin glue [44].…”

“…Platelets can be sequestered and concentrated using gradient density centrifugation [37,40]. Recent reports suggest that platelet-rich plasma may enhance the formation of new bone when used in combination with autogenous graft materials [1, 32,34].…”

Effects of a highly concentrated platelet-rich plasma on the bone repair using non-critical defects in the calvaria of rabbits

“…It is known that platelets are a source of several growth factors, among which are; PDGF [1][2][3][4] , TGF-b 5,6 , VEGF 7,8 , IGF-I 4,9 and EGF 6,10 . This fact stimulated the development of a platelet concentrate with the intention of increasing the levels of local growth factors delivery, which, theoretically, if present at a damaged site, could improve the healing process.…”

“…Several authors started to use the platelet-rich plasma (PRP), mainly in association with autogenous bone graftings 4,7,9,12 , and also to improve soft tissue repair 4,10 .…”