Spinal fusion using an autologous growth factor gel and a porous resorbable ceramic

Walsh, William R.; Loefler, Andreas; Nicklin, Sean; Arm, D.; Stanford, Ralph; Yu, Youcheng; Harris, Richard; Gillies, Robin R.

doi:10.1007/s00586-003-0597-9

Cited by 27 publications

(5 citation statements)

References 46 publications

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“…Lastly, the age of the animal is often reported as "skeletally mature" rather than the specific age or age range. This is important, as fusion rates drop considerably for 5-yearold ewes 34 as compared to 2-3-year-old ewes, 35 In comparison to previous studies, which show either an inferiority of calcium phosphates compared to autograft or equivalence evidenced through weaker endpoints, we demonstrate equivalent performance of AG, BCP granules and BCP putty by an array of strong assessment methods. In clinical literature, we can find conflicting FIGURE 6 Diagrams presenting histomorphometry results of bone tissue (A) and BCP material (B) in the FM of the treated spine segments.…”

Section: Discussionsupporting

confidence: 45%

“…Lastly, the age of the animal is often reported as “skeletally mature” rather than the specific age or age range. This is important, as fusion rates drop considerably for 5‐year‐old ewes as compared to 2‐3‐year‐old ewes, both of which are skeletally mature. The 4 to 5 ‐year‐old sheep used in the present study present an additional relevant challenge for the graft to overcome.…”

Section: Discussionmentioning

confidence: 99%

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Biphasic calcium phosphate with submicron surface topography in an Ovine model of instrumented posterolateral spinal fusion

Dijk

Duan

Luo³

et al. 2018

JOR Spine

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As spinal fusions require large volumes of bone graft, different bone graft substitutes are being investigated as alternatives. A subclass of calcium phosphate materials with submicron surface topography has been shown to be a highly effective bone graft substitute. In this work, a commercially available biphasic calcium phosphate (BCP) with submicron surface topography (MagnetOs; Kuros Biosciences BV) was evaluated in an Ovine model of instrumented posterolateral fusion. The material was implanted stand‐alone, either as granules (BCP granules ) or as granules embedded within a fast‐resorbing polymeric carrier (BCP putty ) and compared to autograft bone (AG). Twenty‐five adult, female Merino sheep underwent posterolateral fusion at L2‐3 and L4‐5 levels with instrumentation. After 6, 12, and 26 weeks, outcomes were evaluated by manual palpation, range of motion (ROM) testing, micro‐computed tomography, histology and histomorphometry. Fusion assessment by manual palpation 12 weeks after implantation revealed 100% fusion rates in all treatment groups. The three treatment groups showed a significant decrease in lateral bending at the fusion levels at 12 weeks ( P < 0.05) and 26 weeks ( P < 0.001) compared to the 6 week time‐point. Flexion‐extension and axial rotation were also reduced over time, but statistical significance was only reached in flexion‐extension for AG and BCP putty between the 6 and 26 week time‐points ( P < 0.05). No significant differences in ROM were observed between the treatment groups at any of the time‐points investigated. Histological assessment at 12 weeks showed fusion rates of 75%, 92%, and 83% for AG, BCP granules and BCP putty , respectively. The fusion rates were further increased 26 weeks postimplantation. Similar trends of bone growth were observed by histomorphometry. The fusion mass consisted of at least 55% bone for all treatment groups 26 weeks after implantation. These results suggest that this BCP with submicron surface topography, in granules or putty form, is a promising alternative to autograft for spinal fusion.

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Section: Discussionsupporting

confidence: 45%

Section: Discussionmentioning

confidence: 99%

Biphasic calcium phosphate with submicron surface topography in an Ovine model of instrumented posterolateral spinal fusion

Dijk

Duan

Luo³

et al. 2018

JOR Spine

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“…Des Weiteren sind, abhängig von der Lokalisation der zu fusionierenden Segmente, deutliche Unterschiede in den Fusionsraten beschrieben. [19] 70 % (50 %) partiell Röntgen (CT) Santos et al 2003 [23] 84 % (65 %) Röntgen (CT) Walsh et al 2004 [24] 67 % 17 % Röntgen Suchomel et al 2004 [17] 94,6 % 93,4 % Burkus et al 2005 [16] 89…”

Section: Abb 4 Präoperative Diagnosen Der Patientenunclassified

Vergleich der anterioren lumbalen Fusionsrate nach dorsoventraler Fusion unter Einsatz von β-Trikalziumphosphat (Cerasorb®) versus autologer Beckenkammspongiosa

Hagel¹,

A²,

Hein³

et al. 2007

Z Orthop Unfall

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“…In experimental works, where spondylosyndesis was studied in a variety of animal models [48][49][50][51][52], different strategies for obtaining and application of PRP were used. But, despite the non-unified experimental protocols, the results of most studies indicate the effectiveness of this biotechnology.…”

Section: Introductionmentioning

confidence: 99%

The Results of Autotransfusion With Platelet Rich Plasma in Spinal Neurosurgery

Pedachenko¹

2018

Ž. klìn. eksp. med. dosl.

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THE RESULTS OF AUTOTRANSFUSION WITH PLATELET RICH PLASMA IN SPINAL NEUROSURGERY. Introduction. Рlatelet-rich plasma (PRP), a blood plasma separated by centrifugation with highly abundant platelets, has multiple applications in many healthcare fields for the improvement of soft and bone tissues regeneration. The studies of PRP implementation results in spine neurosurgery are of high demand in case of pathologies related to the degeneration or injury of living bone and cartilaginous elements of vertebral column, which require the installation of vertebral interbody fusion system. Purpose. Improvement of surgical treatment outcomes by means of improving postoperative wound healing and reducing pain severity after the installation of transpedicular fixation systems in the lumbar spine using a biotechnological method which has a multimodal effect on regeneration processes and is simple and cost-effective Materials and Methods. The results of transpedicular stabilization in lumbar spine vertebral column were assessed within the early postoperational period in two groups of patients comparable in age and health status with spondylolisthesis and spinal motion segment instability. Patients from the main group (n = 20, average age 47.8 ± 6.6 years) received PRP during the operation as compared to the control one (n = 30, average age 46.9 ± 5.6 years) without PRP injections. Results. It was found that during the first day post-operation the pain severity in the main group was significantly reduced (1.6 ± 0.7 points according to the visual analogous scale) as compared to the control (3.8 ± 0.9 points). Moreover, these characteristics before the discharge of the patients were 0.3 ± 0.3 and 2.0 ± 0.4 points respectively. It is noteworthy that the swelling and wound edges hyperemia were remarkably reduced after the PRP use. Finally, no complications, side-effect or systemic consequences of PRP were observed. Conclusions. Therefore, the local injections of PRP during the installment of transpedicular stabilization system in lumbar spine is easyto-handle and safe approach favoring the quick recovery in early postoperational period.

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Spinal fusion using an autologous growth factor gel and a porous resorbable ceramic

Cited by 27 publications

References 46 publications

Biphasic calcium phosphate with submicron surface topography in an Ovine model of instrumented posterolateral spinal fusion

Biphasic calcium phosphate with submicron surface topography in an Ovine model of instrumented posterolateral spinal fusion

Vergleich der anterioren lumbalen Fusionsrate nach dorsoventraler Fusion unter Einsatz von β-Trikalziumphosphat (Cerasorb®) versus autologer Beckenkammspongiosa

The Results of Autotransfusion With Platelet Rich Plasma in Spinal Neurosurgery

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