Aluminum toxicology and the aluminum-containing medications

Lione, Armand

doi:10.1016/0163-7258(85)90032-4

Cited by 88 publications

(35 citation statements)

References 181 publications

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“…Aluminum hydroxide, administered therapeutically in large quantities as an antacid and phosphate binder has been suggested to contribute to aluminum accumulation and toxicity (Lione 1985). Chronic exposition can cause alterations in skeletal, nervous, hematopoietic and respiratory systems (Chen et al 2002;Cambell 2002).…”

Section: Introductionmentioning

confidence: 99%

Determination of blood indices of albino rats treated with aluminum chloride and investigation of antioxidant effects of vitamin E and C

Aziz

Zabut²

2011

Egypt. J. Bio.

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The current study aims to investigate hematological and biochemical blood indices of albino rats administrated aluminum chloride (AlCl 3 ) for eight weeks, and to study the therapeutic effects of vitamin E and C. AlCl 3 decreased the total red blood cell count (by 18%), hemoglobin (7%) and hematocrit (20%), and increased white blood cell count (67%), lymphocytes (29%), mean corpuscular volume (14%), mean corpuscular hemaglobin (6%) and platelets (33%). Administration of vitamin E with or without vitamin C failed to restore levels of red blood cell counts, hematocrit, mean corpuscular volume, mean corpuscular hemaglobin or platelets, but vitamin E on its own restored levels of white blood cells, hemaglobin and lymphocytes.AlCl 3 decreased serum glucose levels by 30%, and increased triglyceride (28%) and cholesterol (20%) levels; neither vitamin treatments restored the levels of these components. AlCl 3 increased levels of urea (12%), uric acid (77%) and creatinine (25%) compared to the controls, and vitamin E separately or together with vitamin C restored the levels of these nitrogen compounds.The activities of alanine aminotransferase, alkaline phosphatase, and aspartate aminotransferase were also increased by the AlCl 3 treatment; the first two but not aspartate aminotransferase were restored by vitamin E separately or together with vitamin C.We conclude that vitamin E separately or together with vitamin C suppressed cytogenetic injury and damage to some biochemical pathways of rat organs induced by AlCl 3 .

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Section: Introductionmentioning

confidence: 99%

Determination of blood indices of albino rats treated with aluminum chloride and investigation of antioxidant effects of vitamin E and C

Aziz

Zabut²

2011

Egypt. J. Bio.

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“…Furthermore, it is widely used in food additives and toothpaste [7] . Aluminum compounds are widely used in medicines, e.g., antacids, phosphate binders, buffered aspirins, vaccines and injectable allergens [8][9][10] . Environmental pollution with different aluminum-containing compounds, especially industrial waste water, exposes people to higher than normal levels of aluminum [11] .…”

Section: Introductionmentioning

confidence: 99%

Camel's Milk Protects against Aluminum Chloride-Induced Toxicity in the Liver and Kidney of White Albino Rats

Al‐Hashem¹

2009

American Journal of Biochemistry and Biotechnology

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Problem statement: Aluminum chloride (AlCl 3 ) is commonly used in daily life but it can be potentially toxic. Therefore, the present study was carried out to investigate the protective effects of camel's milk against aluminum-induced biochemical alterations and oxidative stress in the liver and kidney of white albino rats. Approach: White albino male rats (230-250 g) were divided into three groups of 10 rats: a control group treated with normal saline, the AlCl 3 -treated group and the camel's milk-AlCl 3 -treated group. The AlCl 3 treated group received 0.5 mg kg −1 of AlCl 3 orally. The camel's milk-AlCl 3 -treated group was fed 1 mL of fresh camel's milk 10 minutes prior to the administration of oral AlCl 3 . All rats were treated every day for 30 days. Liver and kidney biochemical serum parameters were analyzed. Lipid peroxidation, as determined by the tissue concentrations of thiobarbituric acid reactive substances (TBARS) and hydrogen peroxide (HP), and the oxidative stress status, as measured by glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) activity, were evaluated in the kidney and liver of treated rats. Results: Data showed that the oral administration of AlCl 3 resulted in statistically significant increases in the serum levels of urea, creatinine, bilirubin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), cholesterol and triglycerides; the total amount of protein and albumin were also significantly decreased. However, these parameters were within normal levels in the rats given camel's milk prior to AlCl 3 . Additionally, oral administration of AlCl 3 induced lipid peroxidation in the liver and kidney, which was indicated by a significant increase in lipid peroxidation biomarkers (TBARS and HP) and a significant decrease in the activities of GSH, SOD and CAT. In all rats treated with camel's milk before being given AlCl 3 , lipid peroxidation and oxidative stress parameters were within normal levels. Conclusion: Treatment with camel's milk prior to AlCl 3 exposure alleviates AlCl 3 -associated hazards and protects the kidney and liver from AlCl 3 toxicity.

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“…Aluminum compounds are also broadly used in medicines such as antacids, phosphate binders, buffered aspirin, vaccines and injectable allergens [8][9][10] . Environmental pollution from a variety of aluminumcontaining waste, especially from industrial waste water, increases human exposure beyond normal levels [11] .…”

Section: Introductionmentioning

confidence: 99%

Camel’s Milk Alleviates Oxidative Stress and Lipid Peroxidation Induced by Chronic Aluminum Chloride Exposure in Rat’s Testes

Al‐Hashem¹

2009

American J. of Applied Sciences

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Problem statement: The present study was carried out to examine the effectiveness of Camel's milk in alleviating aluminum chloride (AlCl 3 )-induced oxidative stress and lipid peroxidation in rat testes. Approach: White albino male rats (230-250 g) were divided into three groups of 10 rats: A control group, treated with normal saline and two experimental groups, the AlCl 3 treated group and the Camel's milk-AlCl 3 treated group. The first experimental group, the AlCl 3 treated group, received 0.5 mg kg −1 of AlCl 3 orally. The second experimental group was fed 1 mL of fresh Camel's milk 10 min prior to the administration of oral AlCl 3 . All rats were treated every day for 30 days. Lipid peroxidation, as determined by testicular concentration of Thiobarbituric Acid Reactive Substances (TBARS) and Hydroperoxide (HP) levels and the oxidative stress status, as measured by glutathione (GSH) levels, Superoxide Dismutase (SOD) and Catalase (CAT) activity, were evaluated in the rat testes. Results: Oral administration of AlCl 3 induced lipid peroxidation and oxidative stress in rat testes, which was indicated by a significant increase in lipid peroxidation biomarkers (TBARS and HP) and a significant decrease in the GSH content and SOD and CAT activities. When rats received Camel's milk before being given AlCl 3 , lipid peroxidation and oxidative stress parameters were restored to normal levels. In the testes from rats fed Camel's milk TBARS and HP levels were significantly reduced and, conversely, GSH content, SOD and CAT activities were significantly increased compared to rats that received only AlCl 3 . Conclusion: Treatment with Camel's milk prior to AlCl 3 alleviates AlCl 3 -associated hazards and protects testicular tissue from AlCl 3 toxicity.

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Aluminum toxicology and the aluminum-containing medications

Cited by 88 publications

References 181 publications

Determination of blood indices of albino rats treated with aluminum chloride and investigation of antioxidant effects of vitamin E and C

Determination of blood indices of albino rats treated with aluminum chloride and investigation of antioxidant effects of vitamin E and C

Camel's Milk Protects against Aluminum Chloride-Induced Toxicity in the Liver and Kidney of White Albino Rats

Camel’s Milk Alleviates Oxidative Stress and Lipid Peroxidation Induced by Chronic Aluminum Chloride Exposure in Rat’s Testes

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