Aluminum, Its Absorption, Distribution, and Effects on Phosphorus Metabolism

Ondreicka, R; Kortus, J; Ginter, E

doi:10.1016/b978-0-08-015721-4.50022-7

Cited by 32 publications

(4 citation statements)

References 13 publications

(11 reference statements)

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“…A daily 200 mg/kg dose of AlCl3 brought about an increased fecal excretion but did not cause an accumulation of Al in various tissues. This increased fecal elimination accommodated a slight increase in Al intake but larger Al intakes resulted in increased absorption and retention (488). The most pronounced accumulations of Al were observed in the liver, testes, and bone.…”

Section: Toxicology Of Aluminum and Its Compoundsmentioning

confidence: 88%

Aluminum in the Environment and Human Health

Sorenson¹,

Campbell²,

Tepper³

et al. 1974

Environmental Health Perspectives

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The review of over 800 references on aluminum (Al) published since the mid-fifties covers the occurrence of Al in soil, air, water, plants and food products, as well as air and water pollution problems. In addition, the existing quality criteria, the biology and toxicology of Al, and the therapeutic and medical uses are presented. It is concluded that absorption and retention or accumulation of Al in humans occurs at lower levels of intake than had been assumed formerly. However, levels of 5 to 50 times the normal daily intake do not appear to interfere with other metabolic processes. The adverse effects of Al reported in the more recent years resulted from the inhalation or ingestion of Al in concentrations many times greater than the amounts present under normal circumstances. As in the past, there is still no need for .ncern by the public or producers of Al or its products concerning hazards to human health derived from well established and extensively used products.

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Section: Toxicology Of Aluminum and Its Compoundsmentioning

confidence: 88%

Aluminum in the Environment and Human Health

Sorenson¹,

Campbell²,

Tepper³

et al. 1974

Environmental Health Perspectives

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“…Assuming that the liver is a sensitive indicator of absorbed A1 then it must be inferred from the results of the present study that very little, if any, of the A1 in either tea infusion or tea leaves was retained in the body. One explanation for this may be the high fluoride content of tea which has been reported to increase A1 excretion in the urine and faeces of rats, thereby decreasing body retention (Ondreicka et al 1971). However, the lack of difference in blood A1 would indicate that the A1 in tea was not available for absorption, even in Fe deficiency when the efficiency of absorption of many inorganic elements is raised.…”

Section: Discussionmentioning

confidence: 99%

The effect of tea on iron and aluminium metabolism in the rat

et al. 1991

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Weanling male Wistar rats were fed for 28 d on a semi-synthetic diet containing normal (38 pg/g) or low (9 pg/g) levels of iron. They were given water or tea infusion (20 g leaves/l water) to drink. Two further groups were given a normal-or low-Fe diet containing added tea leaves (20 g/kg diet). At the end of the study period, all rats given the low-Fe diet were severely anaemic, as assessed by haemoglohin, packed cell volume and liver Fe. Those given tea or the diet with added tea leaves showed a greater degree of Fe depletion. The blood and liver aluminium levels were not increased as a result of consuming tea or tea leaves, despite the higher Al intakes. Fe deficiency per se had no effect on A1 absorption or retention from tea. It was concluded that the Al in tea was very poorly absorbed but that tea, either in the form of an infusion or as tea leaves, had an adverse effect on Fe status.Iron metabolism: Aluminium metabolism: Tea: Rat

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“…Any increase in the proportion of aluminium in low molecular mass form in plasma would then be expected to enhance its excretion. Computational studies suggest this effect when plasma citric acid concentration is elevated [23] and the intraperitoneal administration of citric acid has been shown to enhance aluminium excretion in mice [24,25]. It has been shown [22] that silicic acid competes with citrate for aluminium binding at pH > 7 and then an elevated silicic acid concentration in plasma would preserve mobilized aluminium in a low molecular mass form therefore enhancing its excretion.…”

Section: Discussionmentioning

confidence: 99%

Silicon and aluminium and their inter‐relationship in serum and urine after renal transplantation

Bellia

Newton

Davenport

et al. 1994

Eur J Clin Investigation

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Abstract. The present study was undertaken to establish the relationship between serum and urine silicon and improve renal function and examine whether the increased urinary excretion of aluminium observed after successful renal transplantation was associated with silicon. The changes in silicon and aluminium concentrations in serum and urine were measured in 15 patients for a period of up to 17 days following a first renal transplant. Serum silicon, unlike aluminium, progressively decreased with improving renal function and was significantly positively correlated with serum aluminium but not with the silicon excretion. The urine excretion of aluminium peaked between 4-8 days post-transplantation and was highly significantly positively correlated with urine silicon. The individual patient fractional excretion profiles of aluminium and silicon were variable but in general gave significant positive correlations suggesting that the elements may be cleared by the kidney through a common mechanism or as a chemical species, possibly an hydroxyaluminosilicate. If soluble silicon can chemically interact with aluminium in vivo it may, as in the biosphere, be important in the control of aluminium toxicity and eventual detoxification. Thus, elevated serum silicon concentrations may help to alleviate aluminium toxicity in end-stage renal disease and assist in the rapid clearance of aluminium seen after kidney transplantation.

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Aluminum, Its Absorption, Distribution, and Effects on Phosphorus Metabolism

Cited by 32 publications

References 13 publications

Aluminum in the Environment and Human Health

Aluminum in the Environment and Human Health

The effect of tea on iron and aluminium metabolism in the rat

Silicon and aluminium and their inter‐relationship in serum and urine after renal transplantation

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