Aluminum and Glyphosate Can Synergistically Induce Pineal Gland Pathology: Connection to Gut Dysbiosis and Neurological Disease

Abstract

Many neurological diseases, including autism, depression, dementia, anxiety disorder and Parkinson's disease, are associated with abnormal sleep patterns, which are directly linked to pineal gland dysfunction. The pineal gland is highly susceptible to environmental toxicants. Two pervasive substances in modern industrialized nations are aluminum and glyphosate, the active ingredient in the herbicide, Roundup ®. In this paper, we show how these two toxicants work synergistically to induce neurological damage. Glyphosate disrupts gut bacteria, leading to an overgrowth of Clostridium difficile. Its toxic product, p-cresol, is linked to autism in both human and mouse models. p-Cresol enhances uptake of aluminum via transferrin. Anemia, a result of both aluminum disruption of heme and impaired heme synthesis by glyphosate, leads to hypoxia, which induces increased pineal gland transferrin synthesis. Premature birth is associated with hypoxic stress and with substantial increased risk to the subsequent development of autism, linking hypoxia to autism. Glyphosate chelates aluminum, allowing ingested aluminum to bypass the gut barrier. This leads to anemia-induced hypoxia, promoting neurotoxicity and damaging the pineal gland. Both glyphosate and aluminum disrupt cytochrome P450 enzymes, which are involved in melatonin metabolism. Furthermore, melatonin is derived from tryptophan, whose synthesis in plants and microbes is blocked by glyphosate. We also demonstrate a plausible role for vitamin D3 dysbiosis in impaired gut function and impaired serotonin synthesis. This paper proposes that impaired sulfate supply to the brain mediates the damage induced by the synergistic action of aluminum and glyphosate on the pineal gland and related midbrain nuclei.

Analysis and functional characterization of sequence variations in ligand binding domain of thyroid hormone receptors in autism spectrum disorder (ASD) patients

“…Disruption and mutation of TRs have been linked with various disorders. Impaired TR function causing disrupted development in animals due to perinatal exposure to agents like glyphosate and other pesticides are also reported in literature establishing an environmental link in this phenomenon [Seneff, Swanson, & Li, ; Howe et al, ]. Mutations in TRα1 have specifically been implicated in anxiety, memory impairment, and locomotory dysfunction.…”

New Quality-Control Investigations on Vaccines: Micro- and Nanocontamination

“…The detection of presence of Aluminum and NaCl salts is obvious as they are substances used by the Producers and declared as components, but other materials are not supposed to be in the vaccine or in any other injectable drug, at that, and, in any case, Aluminum has already been linked with neurological diseases [27][28][29].…”

Death as a Drug Side Effect in FAERS: Is Glyphosate Contamination a Factor?

“…Albumin and heparin are especially effective at extracting aluminum from glass, and this has brought up a concern for aluminum toxicity in these products following a long storage time in a glass vial [49]. It has been proposed that aluminum may be synergistically toxic with glyphosate [50], and this would be particularly true under conditions of kidney failure when aluminum tends to be stored in the body due to failed kidney function [51]. Parathyroid hormone dramatically increases the retention of aluminum in the brain of rats fed dietary aluminum [52].…”

“…In addition, many items on this list can plausibly be linked to glyphosate. A complex formed by two glyphosate molecules chelating aluminum [50] may behave much like a bisphosphonate to interfere with pyrophosphate-based activities in the cell [66]. Such a complex would be very similar to bisphosphonates in that both molecules contain two phosphonyl groups.…”