Aluminium incorporation into the brain of rat fetuses and sucklings

Yumoto, Sakae; Nagai, Hiroki; Matsuzaki, Hiroyuki; Matsumura, Hiroshi; Tada, Wataru; Nagatsuma, Emiko; Kobayashi, K

doi:10.1016/s0361-9230(01)00509-3

Cited by 75 publications

(36 citation statements)

References 31 publications

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“…32,33 The prospect of fetal damage is even more worrying, because aluminum crosses the placenta and may become fixed in the fetal brain, disturbing its development. 12,34 Reports of psychomotor abnormalities in young rats born to dams fed clay during the gestation period seem to confirm this hypothesis. 35 Geophagy, therefore, seems to provide a potentially large dietary supply of aluminum.…”

Section: Discussionmentioning

confidence: 91%

Plasma and Urinary Aluminum Concentrations in Severely Anemic Geophagous Pregnant Women in the Bas Maroni Region of French Guiana: A Case-Control Study

Lambert¹,

Boukhari²,

Nacher³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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The clays consumed by geophagous individuals contain large quantities of aluminum, a known neurological and hematological toxin. This is the first study to evaluate the risk of aluminum poisoning in geophagous individuals. Blind determinations of plasma and urinary aluminum concentrations were carried out in 98 anemic geophagous pregnant women and 85 non-anemic non-geophagous pregnant women. Aluminum concentrations were significantly higher (P < 0.0001) in the geophagous anemic women than in the controls, with odds ratios of 6.83 (95% confidence interval [CI] = 2.72–19.31) for plasma concentrations (13.92 ± 14.09 μg/L versus 4.95 ± 7.11 μg/L) and 5.44 (95% CI = 2.17–14.8) for urinary concentrations (92.83 ± 251.21 μg/L versus 12.11 ± 23 μg/L). The ingested clay is the most likely source of this overexposure to aluminum. If confirmed, the clinical consequences of this absorption for pregnant women and their offspring should be explored.

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Section: Discussionmentioning

confidence: 91%

Plasma and Urinary Aluminum Concentrations in Severely Anemic Geophagous Pregnant Women in the Bas Maroni Region of French Guiana: A Case-Control Study

Lambert¹,

Boukhari²,

Nacher³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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“…Since Al (Al 3+ ) is a trivalent cation, Al can interact with acidic groups of the peptides, and bind these peptides with one another [40,44,45]. It has been reported that Al ions promote aggregation of physiological concentrations of Abeta peptides in vitro [46].…”

Section: Discussionmentioning

confidence: 99%

Demonstration of aluminum in amyloid fibers in the cores of senile plaques in the brains of patients with Alzheimer’s disease

Yumoto¹,

Kakimi

Ohsaki

et al. 2009

Journal of Inorganic Biochemistry

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146

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“…For instance in the case of Alzheimer's disease (AD), Al 3? has long been associated with the pathogenesis of AD (Yumoto et al 2001;Exley 2006;Walton 2006), albeit controversially. This relationship has been one of the reasons we have pursued the genes involved in the diamideinduced Al 3?…”

Section: Introductionmentioning

confidence: 99%

Delineation of the molecular mechanism for disulfide stress-induced aluminium toxicity

Murphy

O’Doherty

et al. 2012

Biometals

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Following our previous finding that the sulfhydryl-oxidising chemical diamide induced a marked elevation of cellular Al(3+) (Wu et al., Int J Mol Sci, 12:8119-8132, 2011), a further investigation into the underlying molecular mechanism was carried out, using the eukaryotic model organism Saccharomyces cerevisiae. The effects of non-toxic dose of diamide (0.8 mM) and a mild dose of aluminium sulphate (Al(3+)) (0.4 mM) were determined prior to the screening of gene deletion mutants. A total of 81 deletion mutants were selected for this study according to the available screening data against Al(3+) only (Kakimoto et al., BioMetals, 18: 467-474, 2005) and diamide only (Thorpe et al., Proc Natl Acad Sci USA, 101: 6564-6569, 2004). On the basis of our screening data and the cluster analysis, a cluster containing the gene deletions (rpe1∆, sec72∆, pdr5∆ and ric1∆) was found to be specifically sensitive to the mixture of diamide and Al(3+). However gnp1∆, mch5∆ and ccc1∆ mutants were resistant. Dithiothreitol (DTT) and ascorbate markedly reversed the diamide-induced Al(3+) toxicity. Inductively-coupled plasma optical emission spectrometry demonstrated that DTT reduced the intracellular Al(3+) content in diamide/Al(3+)-treated yeast cells six-fold compared to the non-DTT controls. These data together revealed that the pleiotropic drug resistance transporter (Pdr5p) and vacuolar/vesicular transport-related proteins (Ric1p and Sec72p) are the targets of diamide. A dysfunctional membrane-bound Pdr5p terminates the detoxification pathway for Al(3+) at the final step, leading to intracellular Al(3+) accumulation and hence toxicity. As Al(3+) toxicity has been a problem in agriculture and human health, this study has provided a significant step forward in understanding Al(3+) toxicity.

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Aluminium incorporation into the brain of rat fetuses and sucklings

Cited by 75 publications

References 31 publications

Plasma and Urinary Aluminum Concentrations in Severely Anemic Geophagous Pregnant Women in the Bas Maroni Region of French Guiana: A Case-Control Study

Plasma and Urinary Aluminum Concentrations in Severely Anemic Geophagous Pregnant Women in the Bas Maroni Region of French Guiana: A Case-Control Study

Demonstration of aluminum in amyloid fibers in the cores of senile plaques in the brains of patients with Alzheimer’s disease

Delineation of the molecular mechanism for disulfide stress-induced aluminium toxicity

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