Alum in Controlling Hepatic Bleeding; an Animal Model Study

Nouri, Saeed; Farokhi, Shima; Jamali, Bardia; Sharif, Mohammad Reza

doi:10.5812/thrita.21446

Cited by 3 publications

(2 citation statements)

References 17 publications

(15 reference statements)

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“…For this reason, recently, studies have focused on hemostatic agents that do not need to the normal functioning of the body’s hemostatic system. Ferric chloride ( 72 ), potassium aluminum sulfate or alum [KAl (SO 4 ) 2 ] ( 73 ) and aluminum chloride ( 74 ) are among these new agents. These agents have acidic property and exert their haemostatic effects through rapid coagulation of blood proteins.…”

Section: Discussionmentioning

confidence: 99%

The Advantages and Disadvantages of Methods Used to Control Liver Bleeding: A Review

et al. 2015

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Context:Despite advancements in the science of surgery, minimizing bleeding from parenchymal tissue of the liver continues to be one of the challenges surgeons are facing to protect patients’ lives. However, the number of surgeries needing incisions in the liver tissue, e.g. metastatectomy, is constantly increasing.Evidence Acquisition:A MEDLINE and conventional search of the past 50 years of the medical literature was performed to identify relevant articles on hemostasis in the liver parenchymal tissue.Results:The studies that have been published on hemostasis in the liver parenchymal tissue can be classified into 3 categories: 1. surgical procedures; 2. methods affecting body hemodynamic; 3. pharmacological methods. The purpose of these studies are to identify the best therapeutic approaches that not only minimize the bleeding, but also save the maximum amount of the liver tissue and minimize the use of partial liver resections.Conclusions:The excessive blood loss and the long time needed to control the bleeding during liver surgery impose several side effects and complications on patients. Topical hemostatic agents such as ferric chloride, potassium aluminum sulfate (alum) and aluminum chloride are safely applicable in patients. These agents might be used along with other current methods to minimize the blood loss and the need for blood products during liver surgeries.

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Section: Discussionmentioning

confidence: 99%

The Advantages and Disadvantages of Methods Used to Control Liver Bleeding: A Review

et al. 2015

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“…The resected tissues were immediately fixed in formalin and were sent for the pathology report. Based on the defined pathological grading ( 6 - 8 ), the pathology results were classified into 6 groups including: Zero: no change, 1: minor inflammatory infiltration without edema, 2: mild to moderate inflammatory infiltration with mild edema, 3: mild to moderate inflammatory infiltration and moderate edema, 4: moderate inflammation with neutrophils scattered and diffuse edema, 5: severe inflammation of the tissue and edematous changes, fibrosis and hemorrhage.…”

Section: Methodsmentioning

confidence: 99%

Efficacy and Safety of Aluminum Chloride in Controlling External Hemorrhage: An Animal Model Study

Nouri¹,

Sharif²,

Panahi³

et al. 2015

Iran Red Crescent Med J

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Background:Despite all the progress in surgical science, bleeding caused by traffic accidents is still one of the challenges surgeons face in saving patients’ lives. Therefore, introducing an effective method to control external bleeding is an important research priority.Objectives:This study aimed to compare the hemostatic effect of aluminum chloride versus simple suturing in controlling external bleeding.Materials and Methods:This experimental study was conducted in Kashan, Iran. In this study, 60 male Wistar rats were randomly allocated into six groups. An incision, two centimeters (cm) long and half a cm deep, was made on each rat’s shaved back skin and the hemostatic time was measured once using aluminum chloride with different concentrations (5%, 10%, 15%, 25%, and 50%) and then using the control method (controlling hemorrhage by simple suturing). The skin tissue was assessed for pathological changes.Results:The hemostatic time of aluminum chloride 50%, 25%, 15%, 10% and 5% were 8.20 ± 0.919, 14.10 ± 1.37, 21.20 ± 1.31, 30.80 ± 1.68 and 42.00 ± 4.19 seconds, respectively. Also, the mean hemostasis time in the control group (suture) was 84.00 ± 4.05 seconds. The hemostatic times of different concentrations of aluminum chloride were significantly less than that of the control group. There was a statistically significant difference between every two hemostatic time. The pathologic examination showed the highest frequency of low-grade inflammation based on the defined pathological grading.Conclusions:The aluminum chloride method needs less time to control external hemorrhage compared to the control method (controlling external hemorrhage by simple suturing). Aluminum chloride is an effective agent in controlling external hemorrhage in an animal model.

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Evaluation of Anticoagulant Effect of Alum in Rats

Ali Khan,

Bibi,

Siyar

et al. 2024

PBMJ

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Potassium aluminium sulfate, KAl(SO4)2, also called Alum, is an acidic white chemical substance. The role of alum in bleeding and clotting is not fully understood. Objective: To determine the effects of alum on clotting time, D-dimer levels, fasting blood glucose level, and lipid profile. Methods: The study was conducted on 24 male Wistar rats, which were randomly divided into six groups. Four groups were given different concentrations of alum solutions. The remaining two groups received warfarin, and distilled water, which are control, and placebo groups, respectively. Blood tests such as fasting blood sugar (FBS), D-dimers, clotting time, and lipid profile were performed. Results: The study found that the administration of alum prolonged the time it took for blood to coagulate. Alum showed a dose dependent increase in clotting time when compared to the warfarin-control group and group 4 (100 mg/kg alum dose) showed the most significant effect. Similarly, in the case of D-dimers, a dose dependent decrease in the level of D-dimers was seen and the most significant effect was found for high concentration. The plasma blood glucose and lipid level of animals treated with alum did not show any significant effect as compared to placebo. Conclusions: The efficacy of alum as an anticoagulant drug was investigated, and it was found to significantly prolong clotting time while simultaneously reducing the level of D-dimers. Furthermore, it was deemed safe and showed no effects on fasting plasma glucose and lipid profile. The safety profile of alum was assessed to be favorable, thus highlighting its potential as an anticoagulant drug of the future

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Alum in Controlling Hepatic Bleeding; an Animal Model Study

Cited by 3 publications

References 17 publications

The Advantages and Disadvantages of Methods Used to Control Liver Bleeding: A Review

The Advantages and Disadvantages of Methods Used to Control Liver Bleeding: A Review

Efficacy and Safety of Aluminum Chloride in Controlling External Hemorrhage: An Animal Model Study

Evaluation of Anticoagulant Effect of Alum in Rats

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