Altholactone, a novel styryl-lactone induces apoptosis via oxidative stress in human HL-60 leukemia cells

Inayat-Hussain, Salmaan H.; Osman, Annuar Bin; Din, Laily B.; Taniguchi, Naoyuki

doi:10.1016/s0378-4274(02)00025-5

Cited by 53 publications

(25 citation statements)

References 25 publications

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“…This indicates the possibility that DNA damage produced by GTN may not involve production of oxidative stress and not through the mechanisms of oxidative damage. This results is in contrast to our previous finding when we found that altholactone, which is also a styryllactone induces oxidative stress and apoptosis in HL-60 cells (Inayat-Hussain et al, 2002). NAC (1 mM) was able to abrogate both oxidative stress and apoptosis in altholactone treated HL-60 cells.…”

Section: Resultscontrasting

confidence: 99%

Evaluation of the cytotoxic and genotoxic effects of goniothalamin in leukemic cell lines

Rajab

Hamid

Hassan

et al. 2005

Environ. Mutagen Res.

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The cytotoxic and genotoxic effects of goniothalamin, a plant styryllactone, were evaluated using the 3-(4,5 -dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and the Alkaline Comet assay respectively in human leukemic cell lines. Following 72 h of treatment, the IC 50 values of goniothalamin in human HL-60 promyelocytic leukemia cells and CEM-SS T-lymphoblastic cells were 4.5 µg/mL and 2.4 µg/mL respectively. The genotoxicity of goniothalamin in both HL-60 and CEM-SS cells was detected as early as 2 h following treatment at IC 10 and IC 25 concentrations. However, pretreatment with the antioxidant N-acetyl-cysteine (NAC) at 1 mM for 30 minutes did not abrogate genotoxicity of this compound. This result suggests that primary induction of DNA damage by goniothalamin may not involve oxidative damage. In conclusion, our results demonstrate genotoxic damage induced by goniothalamin in leukemic cells. Further studies are needed to ascertain the mode of action of goniothalamin in inducing DNA damage.

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Section: Resultscontrasting

confidence: 99%

Evaluation of the cytotoxic and genotoxic effects of goniothalamin in leukemic cell lines

Rajab

Hamid

Hassan

et al. 2005

Environ. Mutagen Res.

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“…[1] These pyrones show various biological activities, including the inhibition of HIV protease [2] and the inducing of apoptosis, [3] and they act as antileukemic [4] and anticancer agents, [5] plant growth inhibitors, pheromones, and antifeedent, antifungal, antibacterial, and antitumor agents. [6] Compounds having the 5,6-dihydro-α-pyrone moiety, desacetylumuravumbolide (1a) and umuravumbolide (1b), [7] were isolated from Tetradenia riparia of the Lamiaceae family from central and southern Africa.…”

Section: Introductionmentioning

confidence: 99%

Stereoselective Total Synthesis of Umuravumbolide

Shekhar

Reddy

et al. 2011

Eur J Org Chem

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“…induced apoptosis in human HL-60 leukemia cells through generation of ROS(Inayat-Hussain et al 2002).Another styryl lactone, (? )-altholactone (14) exhibited a broad spectrum of immune modulation…”

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Cytotoxic activity and mechanism of action of metabolites from the Goniothalamus genus

2014

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The World Health Organization estimates that 4 billion people or 80 % of the population use plants for curative purposes or for their natural health benefits. Accordingly, biodiversity is an important source of active natural products especially used in traditional medicine as healers transmitted knowledge of traditional usage of medicinal plants from generation to generation whereas pharmacologically active compounds within remained obscure. The present review documents cytotoxicity and anti-cancer potential of known compounds of the Goniothalamus species from the Annonaceae family existing in tropical and subtropical Asia and being intensively used for medicinal purposes.

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Altholactone, a novel styryl-lactone induces apoptosis via oxidative stress in human HL-60 leukemia cells

Cited by 53 publications

References 25 publications

Evaluation of the cytotoxic and genotoxic effects of goniothalamin in leukemic cell lines

Evaluation of the cytotoxic and genotoxic effects of goniothalamin in leukemic cell lines

Stereoselective Total Synthesis of Umuravumbolide

Cytotoxic activity and mechanism of action of metabolites from the Goniothalamus genus

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