A simple and efficient stereoselective total synthesis of desacetylumuravumbolide (1a) and umuravumbolide (1b), starting from commercially available valeraldehyde has been described. The synthetic strategy involves a highly enantiose-
Stereoselective First Total Synthesis, Confirmation of the Absolute Configuration and Bioevaluation of Botryolide-E. -Botryolide-E (I) shows potent activity against S. aureus, good activity against E. coli and B. subtilis, as well as moderate to good antifungal activity. -(REDDY, D. K.; SHEKHAR, V.; PRABHAKAR, P.; BABU, D. C.; RAMESH, D.; SIDDHARDHA, B.; MURTHY, U. S. N.; VENKATESWARLU*, Y.; Bioorg. Med. Chem. Lett. 21 (2011) 3, 997-1000, http://dx.
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