Cytotoxic activity and mechanism of action of metabolites from the Goniothalamus genus

Choo, Chee Yan; Abdullah, Norkamilah; Diederich, Marc

doi:10.1007/s11101-014-9372-2

Cited by 31 publications

(18 citation statements)

References 44 publications

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“…Furthermore, goniothalamin at its non-apoptic concentration inhibits TNF-α-induced nuclear factor (NF)-κB activation without inducing toxicity towards healthy blood cells (Abdulwahab et al, 2011;Choo et al, 2014).…”

Section: Tablementioning

confidence: 99%

Phytochemical screening, total phenolics and antioxidant activities of bark and leaf extracts of Goniothalamus velutinus (Airy Shaw) from Brunei Darussalam

Iqbal

Salim

Lim

2015

Journal of King Saud University - Science

340

262

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Goniothalamus velutinus Airy Shaw belongs to the family Annonaceae which is known to have anticancer, antitumor and many other bioactivities. Natives of Sabah and Sarawak use root decoction of G. velutinus for the treatment of headache and food poisoning while the bark was used as a mosquito repellent. Bark and leaf extracts of this plant, obtained from Brunei Darussalam, were tested for phytochemical and antioxidant activities. Phytochemical screening of plant extracts revealed the presence of alkaloids, steroids, terpenoids and cardiac glycosides. Quantitative determination of total phenolics, total flavonoids, and various in vitro antioxidant activities (DPPH, ABTS and FRAP) of methanolic extract was carried out using colorimetric methods. The total phenolic content, expressed as mg of gallic acid equivalent (GAE) per gram of extract, was found to be 68 mg GAE/g and 78 mg GAE/g for bark and leaves respectively. The radical scavenging activity measurement, expressed in terms of EC 50 (effective concentration of extract in µg/mL that reduces DPPH absorbance to 50% as compared to negative control), for leaf and bark extracts was found to be 155 µg/mL and 204 µg/mL respectively. While standards trolox and ascorbic acid shows EC 50 value of 5 µg/mL and 4 µg/mL respectively. Trolox equivalent antioxidant capacity (TEAC) was measured using the ABTS and FRAP method. Result for bark and leaf extracts was 79 mg and 106 mg Trolox equivalent (TE)/g respectively for ABTS method. For FRAP assay, results for bark and leaf extracts were 80 and 89 mg TE/g respectively.

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Section: Tablementioning

confidence: 99%

Phytochemical screening, total phenolics and antioxidant activities of bark and leaf extracts of Goniothalamus velutinus (Airy Shaw) from Brunei Darussalam

Iqbal

Salim

Lim

2015

Journal of King Saud University - Science

340

262

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“…The percentage yield of methanolic extract for each plant part was calculated using the equation (1) as shown below:…”

Section: Preparation Of Methanolic Extractsmentioning

confidence: 99%

“…The World Health Organization (WHO) reported that approximately 80% of the world's inhabitants rely mainly on traditional medicines for their primary health care. 1,2 Plants contain a wide range of secondary metabolites and phytochemicals such as phenols, flavonoids, steroids, tannins, anthraquinones, saponins, nitrogen compounds (alkaloids, amines, and betalains), terpenoids and many other endogenous -molecules. [3][4][5] Many scientific reports provide evidence for their antioxidant, antimicrobial antiinflammatory, analgesic, antipyretic, anticancer, antitumor, antiviral, antidiabetic, and many others therapeutic values.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antioxidant Activity and Phytochemical Screening of Leaves, Barks, Stems and Fruits of Alphitonia philippinensis (Rhamnaceae) From Brunei Darussalam

Ahmed¹,

Salim²,

Lim³

et al. 2019

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Alphitonia, a genus of the Rhamnaceae family with, approximately 20 species, are available in the tropical regions of Southeast Asia, Polynesia and Oceania. 15,16 This genus is mainly used in traditional medicine by the inhabitants of Samoa, Fiji, Tahiti, Vanuatu, Tonga, Northern Australia and Brunei Darussalam for coughs, constipation, headaches, stomachaches, menstrual pain, prolapsed rectum after postpartum woman, facilitate childbirth, swelling, fever, earache, cancer, skin diseases (eczema, ecthyma, pityriasis), inflammation, rheumatic pains, ulcer, gastrointestinal and urogenital disorders. 16-19 Isolation of a range of bioactive compounds were reported from this genus having antioxidant, antimicrobial, cytotoxic, antiulcer, antityrosinase, inhibitions of ABSTRACT Phytochemical screening of Alphitonia philippinensis extracts revealed the presence of cardiac glycosides, tannins, saponins and steroids in different plant parts. Total phenolic content (TPC), total flavonoid content (TFC) and total flavonol content (TFlC) were measured using spectrophotometric methods where gallic acid and quercetin were the standards. Antioxidant activity of extracts was assessed using 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2-azino-bis(3ethylbenzothiazoline-6-sulfonic acid) (ABTS), free radical scavenging and ferric reducing antioxidant power (FRAP) assays using ascorbic acid and trolox were used as standards. Among the four different crude methanol extracts studies, leaves showed highest antioxidant capacity. EC 50 values of the leaves extract from DPPH and ABTS method found 32 and 45 µg/mL respectively. The higher antioxidant activity of the leaves extract could be correlated with the presence of higher total phenolic content, total flavonoid, and total flavonol contents. According to antioxidant contents and assay results leaves extract possesses highest antioxidant property following fruits, barks and stems.

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“…[6] Since then, severala uthors have updated the information aboutt hese biologically activec ompounds. [7][8][9][10][11] Recently, we reviewed the chemical and biological aspects of goniothalamin-related styryl lactones, [12] highlighting the relevance of these natural products in drug discovery.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Nitrogen‐Containing Goniothalamin Analogues with Higher Cytotoxic Activity and Selectivity against Cancer Cells

et al. 2019

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Two series of racemic goniothalamin analogues displaying nitrogen‐containing groups were designed and synthesized. A total of 19 novel analogues were evaluated against a panel of four different cancer cell lines, along with the normal prostate cell line PNT2 to determine their selectivity. Among them, goniothalamin chloroacrylamide 13 e displayed the lowest IC50 values for both MCF‐7 (0.5 μm) and PC3 (0.3 μm) cells, about 26‐fold more potent than goniothalamin (1). Besides its higher potency, compound 13 e also displayed much higher selectivity than goniothalamin. In contrast, goniothalamin isobutyramide 13 c was the most potent analogue against Caco‐2 cells (IC50=0.8 μm), about 10‐fold more potent and 17‐fold more selective than 1. These results reveal the potential of compounds 13 c and 13 e for further in vivo studies, representing the first goniothalamin analogues with IC50 values in the low micromolar range and high selectivity against MCF‐7, Caco‐2, and PC3 cancer cell lines.

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Cytotoxic activity and mechanism of action of metabolites from the Goniothalamus genus

Cited by 31 publications

References 44 publications

Phytochemical screening, total phenolics and antioxidant activities of bark and leaf extracts of Goniothalamus velutinus (Airy Shaw) from Brunei Darussalam

Phytochemical screening, total phenolics and antioxidant activities of bark and leaf extracts of Goniothalamus velutinus (Airy Shaw) from Brunei Darussalam

Evaluation of Antioxidant Activity and Phytochemical Screening of Leaves, Barks, Stems and Fruits of Alphitonia philippinensis (Rhamnaceae) From Brunei Darussalam

Synthesis of Nitrogen‐Containing Goniothalamin Analogues with Higher Cytotoxic Activity and Selectivity against Cancer Cells

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