Alternative treatment of vaginal infections - in vitro
 antimicrobial and toxic effects of Coriandrum sativum 
L. and Thymus vulgaris 
L. essential oils

Bogavac, Mirjana; Karaman, Maja; Janjušević, Ljiljana; Sudji, Jan; Radovanović, Bojan B; Novaković, Zoran; Simeunović, Jelica; Božin, Biljana

doi:10.1111/jam.12883

Cited by 43 publications

(36 citation statements)

References 33 publications

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“…The EOs tested in this study showed the presence of significant amounts of monoterpenes, mainly represented by thymol, α-pinene, and linalool compounds, in accordance with previous published data even if with different percentile [21] (Table 2). Carvacrol and thymol exerted an interesting anti-Candida in vitro activity both by BM and VC, similar to previous findings [22–24], even against fluconazole-resistant C. glabrata and C. tropicalis strains. α-pinene showed a better activity by BM than VC; conversely, linalyl acetate showed the lowest activity against all strains tested both by two methods.…”

Section: Resultssupporting

confidence: 91%

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Liquid and vapour-phase antifungal activities of essential oils against Candida albicans and non-albicans Candida

Mandras

Nostro

Roana

et al. 2016

BMC Complement Altern Med

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BackgroundThe management of Candida infections faces many problems, such as a limited number of antifungal drugs, toxicity, resistance of Candida to commonly antifungal drugs, relapse of Candida infections, and the high cost of antifungal drugs. Though azole antifungal agents and derivatives continue to dominate as drugs of choice against Candida infections, there are many available data referring to the anticandidal activity of essential oils. Since we have previous observed a good antimicrobial activity of some essential oils against filamentous fungi, the aim of this study was to extend the research to evaluate the activity of the same oils on Candida albicans, C.glabrata and C.tropicalis clinical strains, as well as the effects of related components. Essential oils selection was based both on ethnomedicinal use and on proved antibacterial and/or antifungal activity of some of these oils. Fluconazole and voriconazole were used as reference drugs.MethodsThe minimum inhibitory concentration (MIC) and the minimal fungicidal concentration (MFC) of essential oils (thyme red, fennel, clove, pine, sage, lemon balm, and lavender) and their major components were investigated by the broth microdilution method (BM) and the vapour contact assay (VC).ResultsUsing BM, pine oil showed the best activity against all strains tested, though C.albicans was more susceptible than C.glabrata and C.tropicalis (MIC50-MIC90 = 0.06 %, v/v). On the contrary, sage oil displayed a weak activity (MIC50-MIC90 = 1 %, v/v). Thyme red oil (MIC50-MIC90 ≤ 0.0038 %, v/v for C.albicans and C.tropicalis, and 0.0078- < 0.015 %, v/v for C.glabrata), followed by lemon balm, lavender and sage were the most effective by VC. Carvacrol and thymol showed the highest activity, whereas linalyl acetate showed the lowest activity both by two methods. α-pinene displayed a better activity by BM than VC.ConclusionResults show a good activity of essential oils, mainly thymus red and pine oils, and their components carvacrol, thymol and α-pinene against Candida spp., including fluconazole/voriconazole resistant strains. These data encourage adequately controlled and randomized clinical investigations. The use in vapour phase could have additional advantages without requiring direct contact, resulting in easy of environmental application such as in hospital, and/or in school.

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Section: Resultssupporting

confidence: 91%

“…However, some data suggest that components presented in small amounts in EOs, such as carvacrol, also could play an important role in antimicrobial activity due to the possible synergistic action with other components [24, 25, 32, 33]. …”

Section: Resultsmentioning

confidence: 99%

Liquid and vapour-phase antifungal activities of essential oils against Candida albicans and non-albicans Candida

Mandras

Nostro

Roana

et al. 2016

BMC Complement Altern Med

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“…brine shrimp test Corchorus capsularis 217 The cytotoxicity of the plant was investigated by brine shrimp lethality bioassay which revealed that coriander LC50 was 2.25 mg/ml. brine shrimp test Coriandrum sativum 218 Among the extracts of the plant root, leaf and stem ,the ethyl acetate extract of Coriandrum sativum roots showed the highest antiproliferative activity on MCF-7 cells (IC50 = 200.0 ± 2.6 μg/ml).…”

Section: -216mentioning

confidence: 99%

Anticancer effects of Arabian medicinal plants (part 1) - A review

Al-Snafi¹

2017

IOSRPHR

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Many Arabian medicinal plants possessed anticancer activitys by many mechanisms as tested by different anticancer tests. These plants included: Adonis aestivalis, Ailanthus altissima, Alhagi maurorum, Allium cepa, Allium sativum, Allium schoenoprasum, Althaea officinalis, Althaea rosea, Ammannia baccifera, Anagyris foetida, Anchusa italica, Antirrhinum majus, Apium graveolens, Arctium Lappa, Aristolochia maurorum, Artemisia campestris, Arundo donax, Asclepias curassavica, Asparagus officinalis, Astragalus hamosus, Bauhinia variegata, Bellis perennis, Betula alba, Bidens tripartita, Brassica rapa, Bryonia dioica, Bryophyllum calycinum, Caccinia crassifolia, Caesalpinia crista, Calendula officinalis, Calotropis procera, Canna indica, Capparis spinosa, Capsella bursa-pastoris, Capsicum annuum , Capsicum frutescens, Carthamus tinctorius, Casuarina equisetifolia, Celosia cristata, Chenopodium album, Chrozophora tinctoria, Cicer arietinum, Cichorium intybus, Citrullus colocynthis, Citrus species, Clerodendron inerme, Clitoria ternatea, Convolvulus arvensis, Convolvulus scammonia, Corchorus aestuans, Corchorus capsularis, Coriandrum sativum, Coronilla scorpioides, Coronilla varia, Cotoneaster racemiflora, Crocus sativus, Cuminum cyminum, Cupressus sempervirens, Cuscuta planiflora, Cydonia oblonga, Cynodon dactylon, Cyperus rotuntdus, Dactyloctenium aegyptium, Datura metel , Daucus carota, Delphinium brunonianum, Desmostachya bipinnata, Dianthus caryophyllus, Digitalis lanata , Digitalis purpurea, Dodonaea viscosa, Lablab purpureus, Echinochloa crus-galli, Equisetum arvense, Erigeron canadensis, Erodium cicutarium, Eryngium creticum, Eucalyptus species, Eupatorium cannabinum, Euphorbia hirta, Euphorbia macroclada, Fagopyrum esculentum, Ficus carica , Ficus cunia and Ficus religiosa. The current paper will discuss the anticancer effects of some medicinal plants as a first part of this review.

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“…Coriandrum leaves have been reported to have antidiabetic, anti ulcer, anti-arthritic and several other medicinal uses [10]. Studies showed that Coriandrum leaves extract has anticancer activity [11]. Studies also showed that reversal of memory deficit in mice model is possible using Coriandrum leaves extract [12].…”

Section: Introductionmentioning

confidence: 97%

Beneficial Effects of Ethanolic Leaf Extract of Coriandrum Sativum on Metanil Yellow Induced Alteration Inactivity of Catalase and Level of Lipid Peroxidation in Hercine Cardiac Tissue in Vitro

Dome¹,

Hazra²,

Ghosh³

et al. 2017

Int J Pharm Pharm Sci

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Objective: The primary aim of the study was to find out a suitable effective dose of metanil yellow that can cause alterations of lipid peroxidation and catalase activity in the heart in vitro and to determine the effectiveness of graded doses of Coriandrum sativum as an antioxidant in preventing lipid peroxidative damage to cardiac tissue and back up catalase activity. Methods:Metanil yellow at different doses (10, 25, 35, 50 µl in phosphate buffer) were applied on isolated hircine heart homogenate (10%) in in vitro followed by estimation of lipid peroxidation and catalase activity after completion of the incubation period. Another set of the experiment included incubation of the heart homogenates with graded dilutions of ethanolic leaf extracts of Coriandrum sativum (CsEth) at concentrations of 10, 20, 30, 40 µl in phosphate buffer medium followed by quantification of the same biochemical parameters as above. This was followed by coadministration of the selected effective dose of metanil yellow (35 µl) and ethanolic leaf extract of Coriandrum sativum (30 µl) on heart homogenate to track the variation in lipid peroxidation and catalase activity in heart homogenate in vitro.

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Alternative treatment of vaginal infections - in vitro antimicrobial and toxic effects of Coriandrum sativum L. and Thymus vulgaris L. essential oils

Abstract: To examine EOs as possible constituent of naturally based antimicrobial agents in vaginaletes for safety gynaecological application.

Cited by 43 publications

References 33 publications

Liquid and vapour-phase antifungal activities of essential oils against Candida albicans and non-albicans Candida

Liquid and vapour-phase antifungal activities of essential oils against Candida albicans and non-albicans Candida

Anticancer effects of Arabian medicinal plants (part 1) - A review

Beneficial Effects of Ethanolic Leaf Extract of Coriandrum Sativum on Metanil Yellow Induced Alteration Inactivity of Catalase and Level of Lipid Peroxidation in Hercine Cardiac Tissue in Vitro

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