Alternative natural sources for a new generation of antibacterial agents

Taylor, Peter W.

doi:10.1016/j.ijantimicag.2013.05.004

Cited by 121 publications

(80 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, garlic may be effective against drug-resistant bacteria, and research has revealed that as allicin digests in your body, it produces sulfonic acid, a compound that reacts with dangerous free radicals faster than any other known compound. In order to get the health benefits, the fresh clove must be crushed or chopped in order to stimulate the release of an enzyme called alliinase, which in turn catalyzes the formation of allicin (Tessema et al, 2006 andTaylor, 2013).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Effect of Ethanolic Extract of Allium sativum on Biofilm Forming Staphylococcus aureus which Cause Folliculitis

Bayati¹

2018

Int.J.Curr.Microbiol.App.Sci

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Antibacterial Effect of Ethanolic Extract of Allium sativum on Biofilm Forming Staphylococcus aureus which Cause Folliculitis

Bayati¹

2018

Int.J.Curr.Microbiol.App.Sci

View full text Add to dashboard Cite

“…Emergence of antibiotic resistance in planktonic bacteria and of their biofilm counterpart is currently guiding the interest of researchers towards alternative drug sources, mostly from immense natural diversity (Abreu et al 2012;Taylor 2013). Primarily the secondary metabolites from the plants have shown the antimicrobial effects and are being used as a major source of drugs having minor or no side effects (Newman and Cragg 2012).…”

Section: Discussionmentioning

confidence: 99%

Effect of Bacoside A on growth and biofilm formation by Staphylococcus aureus and Pseudomonas aeruginosa

Parai

Islam

Mitra³

et al. 2017

Can. J. Microbiol.

View full text Add to dashboard Cite

The goal of this study was to evaluate the antibiofilm and antimicrobial activities of Bacoside A, a mixture formulation of phytochemicals from Bacopa monnieri against Staphylococcus aureus and Pseudomonas aeruginosa which are known to form biofilm as one of their virulence traits. The antimicrobial effects of Bacoside A were tested using the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) assays. Cell membrane disruption assay was performed to find its possible target site. MTT assay, crystal violet assay and microscopic studies were performed to assess the antibiofilm activity.Bacoside A showed its antimicrobial activity against both the test organisms in their planktonic and biofilm states. It could significantly remove ~88-93% bacterial biofilm developed on microtiter plate at sub-minimum inhibitory concentration of 200 µg mL -1 .Biochemical and microscopic studies suggested that the eradication of biofilm might be due to the loss of extracellular polymeric substances and change in cell membrane integrity of the selected bacterial strains treated with Bacoside A. These results indicate that Bacoside A might be considered as an antimicrobial having ability to disrupt biofilms, thus it could alone or in combination with other therapeutics be useful to treat biofilm related infections caused by opportunistic bacterial pathogens.

show abstract

“…[2] Traditional and complementary medicine is used by the majority of the world's population. [3] Several studies have shown that herbal extracts commonly used in folkloric medicine have high bactericidal or bacteriostatic potential. [3] Indeed, conventional antibiotics are generally secondary metabolites of microbial or plant origin with low molecular weight (less than 1000 Da).…”

Section: Introductionmentioning

confidence: 99%

“…[3] Several studies have shown that herbal extracts commonly used in folkloric medicine have high bactericidal or bacteriostatic potential. [3] Indeed, conventional antibiotics are generally secondary metabolites of microbial or plant origin with low molecular weight (less than 1000 Da). [4] A recent survey reveals that natural products or natural product-based drugs account for >75% of the 97 antibacterial new chemical entities (NCEs) approved and marketed over the last three decades [5] emphasizing the ongoing importance of natural products as the basis for new treatments of bacterial infectious diseases.…”

Section: Introductionmentioning

confidence: 99%

“…[4] A recent survey reveals that natural products or natural product-based drugs account for >75% of the 97 antibacterial new chemical entities (NCEs) approved and marketed over the last three decades [5] emphasizing the ongoing importance of natural products as the basis for new treatments of bacterial infectious diseases. [3] The rising problem of antibiotic resistance is a major threat to public health worldwide. [6] Antimicrobial resistance continues to increase among key pathogens, placing a significant burden on health care systems and humanity.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antibacterial activities of Rhazya stricta leaf extracts against multidrug-resistant human pathogens

Khan

Baeshen

Saini

et al. 2016

Biotechnology & Biotechnological Equipment

View full text Add to dashboard Cite

Bacterial resistance to antibiotics, first a major concern in the 1960s, has re-emerged worldwide over the last 20 years. The World Health Organization (WHO) and other health organizations have, therefore, declared 'war' against human microbial pathogens, particularly hospital-acquired infections, and have made drug discovery a top priority for these diseases. Because these bacteria are refractory to conventional chemotherapy, medicinal and herbal plants used in various countries should be assessed for their therapeutic potential; these valuable bio-resources are a reservoir of complex bioactive molecules. Earlier studies from our laboratory on Rhazya stricta, a native herbal shrub of Asia, have shown that this plant has a number of therapeutic properties. In this study, we evaluated the antimicrobial activities of various concentrations of five solvent extracts (aqueous alkaloid, aqueous non-alkaloid, organic alkaloid, organic non-alkaloid and whole aqueous extracts) derived from R. stricta leaves against several multidrug-resistant, human-pathogenic bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and extended-spectrum betalactamase-positive Escherichia coli. In vitro, molecular and electron microscopy analyses conclusively demonstrated the antimicrobial effects of these extracts against a panel of Gramnegative and Gram-positive bacteria. The organic alkaloid extract was the most effective against E. coli and MRSA, resulting in cell membrane disruption visible with transmission electron microscopy. In the near future, we intend to further focus and delineate the molecular mechanism-of-action for specific alkaloids of R. stricta, particularly against MRSA.

show abstract

Alternative natural sources for a new generation of antibacterial agents

Cited by 121 publications

References 89 publications

Antibacterial Effect of Ethanolic Extract of Allium sativum on Biofilm Forming Staphylococcus aureus which Cause Folliculitis

Antibacterial Effect of Ethanolic Extract of Allium sativum on Biofilm Forming Staphylococcus aureus which Cause Folliculitis

Effect of Bacoside A on growth and biofilm formation by Staphylococcus aureus and Pseudomonas aeruginosa

Antibacterial activities of Rhazya stricta leaf extracts against multidrug-resistant human pathogens

Contact Info

Product

Resources

About