Altered Transcriptional Regulation of Cytokines, Growth Factors, and Apoptotic Proteins in the Endometrium of Infertile Women with Chronic Endometritis

Pietro, Cinzia Di; Cicinelli, Ettore; Guglielmino, Maria Rosa; Ragusa, Marco; Farina, Marco; Palumbo, Marco; Cianci, Antonio

doi:10.1111/aji.12076

Cited by 118 publications

(109 citation statements)

References 27 publications

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“…It is therefore possible to speculate that a chronic inflammatory process in the endometrium could influence JZ functionality. In women with CE, an abnormal pattern of lymphocyte subsets and, consequently, an aberrant endometrial microenvironment have been demonstrated (18,19). It is possible to speculate that the altered leukocyte population and the altered pattern of paracrine factors could influence the nearby endometrium of the JZ, inducing an altered contractility.…”

Section: Discussionmentioning

confidence: 99%

Altered uterine contractility in women with chronic endometritis

Pinto

Matteo

Tinelli

et al. 2015

Fertility and Sterility

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Section: Discussionmentioning

confidence: 99%

Altered uterine contractility in women with chronic endometritis

Pinto

Matteo

Tinelli

et al. 2015

Fertility and Sterility

Self Cite

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“…S4C). In addition, IFN-stimulated genes, some cytokines and chemokines in the endometrium related to implantation, including CCL2, CCL4, CCL20, CCL5 , and CXCL8 16171819, were also up-regulated. Another up-regulated gene, CSF1 , is a specific hemopoietic growth factor regulating survival, proliferation and differentiation of mononuclear phagocytes.…”

Section: Resultsmentioning

confidence: 98%

“…Whereas, a lot of IFN-stimulated genes including ISG family, IFIT, IRF, MX , and some cytokines/chemokines including CCL2, CCL4, CCL20, CCL5, and CXCL8 16171819 were up-regulated. Among these genes, OPN was a powerful gene involved in embryo implantation.…”

Section: Discussionmentioning

confidence: 98%

Deep sequencing of transcriptome profiling of GSTM2 knock-down in swine testis cells

Jin

Zhou

et al. 2016

Sci Rep

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Glutathione-S-transferases mu 2 (GSTM2), a kind of important Phase II antioxidant enzyme of eukaryotes, is degraded by nonsense mediated mRNA decay due to a C27T substitution in the fifth exon of pigs. As a reproductive performance-related gene, GSTM2 is involved in embryo implantation, whereas, functional deficiency of GSTM2 induces pre- or post-natal death in piglets potentially. To have some insight into the role of GSTM2 in embryo development, high throughput RNA sequencing is performed using the swine testis cells (ST) with the deletion of GSTM2. Some embryo development-related genes are observed from a total of 242 differentially expressed genes, including STAT1, SRC, IL-8, DUSP family, CCL family and integrin family. GSTM2 affects expression of SRC, OPN, and SLCs. GSTM2 suppresses phosphorylation of STAT1 by binding to STAT1. In addition, as an important transcription factor, STAT1 regulates expression of uterus receptive-related genes including CCLs, IRF9, IFITs, MXs, and OAS. The present study provides evidence to molecular mechanism of GSTM2 modulating embryo development.

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“…In EM with CE, the IGFBP1 gene was upregulated, whereas genes such as IGF1 , IL-11 , and CCL4 were downregulated [66]. IGF1 mediated the effect of estrogen on endometrial proliferation, while IGF2 mediated the effect of progesterone during the secretory phase by facilitating the implantation and invasion of embryos [596768].…”

Section: Pathophysiology Of Cementioning

confidence: 99%

“…In summary, chronic endometrial inflammation can alter endometrial cytokine production, damage endometrial function [73], result in the formation of abnormal patterns of lymphocyte subsets in the EM, and induce the altered secretion of paracrine factors, which ultimately may reduce the receptivity of embryos in the EM [6066]. In fact, delayed differentiation of the EM in the mid-secretory phase (out-of-phase morphology) was observed in cases of CE [74].…”

Section: Pathophysiology Of Cementioning

confidence: 99%

Chronic endometritis and infertility

Park

Kim

Yoon

et al. 2016

Clin Exp Reprod Med

141

111

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Chronic endometritis (CE) is a condition involving the breakdown of the peaceful co-existence between microorganisms and the host immune system in the endometrium. A majority of CE cases produce no noticeable signs or mild symptoms, and the prevalence rate of CE has been found to be approximately 10%. Gynecologists and pathologists often do not focus much clinical attention on CE due to the time-consuming microscopic examinations necessary to diagnose CE, its mild clinical manifestations, and the benign nature of the disease. However, the relationship between CE and infertility-related conditions such as repeated implantation failure and recurrent miscarriage has recently emerged as an area of inquiry. In this study, we reviewed the literature on the pathophysiology of CE and how it may be associated with infertility, as well as the literature regarding the diagnosis and treatment of CE. In addition, we discuss the value of hysteroscopic procedures in the diagnosis and treatment of CE.

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Altered Transcriptional Regulation of Cytokines, Growth Factors, and Apoptotic Proteins in the Endometrium of Infertile Women with Chronic Endometritis

Abstract: The altered gene endometrial expression may explain the impaired endometrial receptivity and the finding of endometrial hyperplastic lesions in women affected by CE.

Cited by 118 publications

References 27 publications

Altered uterine contractility in women with chronic endometritis

Altered uterine contractility in women with chronic endometritis

Deep sequencing of transcriptome profiling of GSTM2 knock-down in swine testis cells

Chronic endometritis and infertility

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