Altered speech-related cortical network in frontotemporal dementia

Suppa, Antonio; Fabbrini, A; Guerra, Andrea; Petsas, Nikolaos; Asci, Francesco; Stasio, Flavio Di; Trebbastoni, Alessandro; Vasselli, Federica; Lena, Carlo de; Pantano, P.

doi:10.1016/j.brs.2020.02.029

Cited by 7 publications

(5 citation statements)

References 45 publications

(36 reference statements)

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“…We also found that phonemic fluency performance was associated with parts of left superior and ventrolateral frontal lobe. Similar ventral clusters were previously associated with phonemic fluency in nfvPPA 28 and in healthy adults. 29 The observed region has been associated with phonological/articulatory planning processes or lexical retrieval 30 and verbal working memory.…”

Section: Discussionsupporting

confidence: 83%

Structural correlates of language processing in primary progressive aphasia

Chapman

Polyakova

Mueller

et al. 2023

Brain Communications

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Understanding the relationships between brain structure and language behavior in primary progressive aphasia provides crucial information about these diseases’ pathomechanisms. However, previous investigations have been limited from providing a statistically reliable view of broad language abilities by sample size, variant focus, and task focus. In this study, the authors aimed to determine the relationship between brain structure and language behavior in primary progressive aphasia, to determine the degree to which task-associated regions were atrophied across disease variants, and to determine the degree to which task-related atrophy overlaps across disease variants. Participants were 118 primary progressive aphasia patients and 61 healthy, age-matched controls tested from 2011 to 2018 in the German Consortium for Frontotemporal Lobar Degeneration cohort. Diagnosis of primary progressive aphasia required progressive deterioration of mainly speech and language for ≥ 2 years, and variant was diagnosed by the criteria of Gorno-Tempini et al.2 Twenty-one participants not fulfilling a specific subtype were classified as mixed-variant and excluded. Language tasks of interest included the Boston Naming Test, a German adaptation of the Repeat and Point task, phonemic and category fluency tasks, and the reading/writing subtest of the Aachen Aphasia Test. Brain structure was measured by cortical thickness. We observed networks of language task-associated temporal, frontal, and parietal cortex. Overlapping task-associated atrophy was observed in the left lateral, ventral, and medial temporal lobe, middle and superior frontal gyrus, supramarginal gyrus, and insula. Some regions, primarily in the perisylvian region were associated with language behavior despite showing no significant atrophy. The results crucially extend less powerful studies associating brain and language measures in primary progressive aphasia. Cross-variant atrophy in task-associated regions suggests partially shared underlying deficits, whereas unique atrophy reinforces variant-specific deficits. Language task-related regions that are not obviously atrophied suggest regions of future network disruption and encourage understanding of task deficits beyond clearly atrophied cortex. These results may pave the way for new treatment approaches.

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Section: Discussionsupporting

confidence: 83%

Structural correlates of language processing in primary progressive aphasia

Chapman

Polyakova

Mueller

et al. 2023

Brain Communications

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“…Interestingly, evidence from behavioral brain imaging and brain stimulation studies suggests that primary motor cortex (M1) stimulation by tDCS may represent a promising and clinically feasible approach to enhance language therapy outcomes in post-stroke aphasia [ 9 ]. A few studies have also found that repetitive TMS stimulating area M1 can improve speech functions such as verbal fluency and naming to varying degrees, as well as enhance cognitive function to some extent [ 23 , 24 , 25 ]. However, there is little research on whether iTBS stimulation of M1 in the affected cortex induces changes in the brains after stroke.…”

Section: Introductionmentioning

confidence: 99%

Capturing Neuroplastic Changes after iTBS in Patients with Post-Stroke Aphasia: A Pilot fMRI Study

et al. 2021

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Intermittent theta-burst stimulation (iTBS) is a high-efficiency transcranial magnetic stimulation (TMS) paradigm that has been applied to post-stroke aphasia (PSA). However, its efficacy mechanisms have not been clarified. This study aimed to explore the immediate effects of iTBS of the primary motor cortex (M1) of the affected hemisphere, on the functional activities and connectivity of the brains of PSA patients. A total of 16 patients with aphasia after stroke received iTBS with 800 pulses for 300 s. All patients underwent motor, language, and cognitive assessments and resting-state functional MRI scans immediately before and after the iTBS intervention. Regional, seed-based connectivity, and graph-based measures were used to test the immediate functional effects of the iTBS intervention, including the fractional amplitude of low-frequency fluctuation (fALFF), degree centrality (DC), and functional connectivity (FC) of the left M1 area throughout the whole brain. The results showed that after one session of iTBS intervention, the fALFF, DC, and FC values changed significantly in the patients’ brains. Specifically, the DC values were significantly higher in the right middle frontal gyrus and parts of the left parietal lobe (p < 0.05), while fALFF values were significantly lower in the right medial frontal lobe and parts of the left intracalcarine cortex (p < 0.05), and the strength of the functional connectivity between the left M1 area and the left superior frontal gyrus was reduced (p < 0.05). Our findings provided preliminary evidences that the iTBS on the ipsilesional M1 could induce neural activity and functional connectivity changes in the motor, language, and other brain regions in patients with PSA, which may promote neuroplasticity and functional recovery.

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“…The following left-hemisphere regions were obtained: pars opercularis, pars orbitalis, pars triangularis of the inferior frontal gyrus (IFG), superior temporal gyrus (STG), middle temporal gyrus, inferior temporal gyrus, anterior temporal gyrus (ATG), posterior temporal gyrus, and dorsolateral prefrontal cortex (DLPFC). We selected these regions because they have been reported to be prominent areas of atrophy in individuals with nfvPPA and because they have also been implicated in language in studies of individuals with PPA and HC (Brambati et al, 2009; Davies et al, 2005; Ikeda et al, 1996; Lippa et al, 1991; Mesulam et al, 2009; Rogalski et al, 2011; Shim et al, 2012; Suppa et al, 2020; Wilson et al, 2010).…”

Section: Methodsmentioning

confidence: 99%

The Impact of Primary Progressive Aphasia on Picture Naming and General Language Ability

Peristeri

Messinis

Kosmidis

et al. 2021

Cognitive and Behavioral Neurology

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Background: Primary progressive aphasia (PPA) is a clinical syndrome that is characterized by progressive deterioration of language while other cognitive domains remain relatively intact. The extent to which print exposure and cortical volume atrophy jointly influence picture naming and general language ability in individuals with PPA remains underexplored. Objective: To investigate the language performance of individuals with the nonfluent variant of primary progressive aphasia (nfvPPA) and to explore the impact of print exposure and cortical volume atrophy on their language ability. Method: We compared 14 Greek individuals with nfvPPA and similar age, education, disease duration, and cognitive ability with age-, gender- and education-matched Greek controls on picture naming and on language tasks of the Boston Diagnostic Aphasia Examination—Short Form, including oral word reading, word and sentence repetition, complex ideational material, and reading comprehension. The effects of print exposure and left-hemisphere cortical volume on the individuals’ language performance were estimated through stepwise regression models. Results: The language performance of the individuals with nfvPPA was affected by print exposure and cortical volume atrophy. Picture naming and word reading were affected by print exposure. The highest contributions of cortical volume atrophy were found for the repetition, complex ideational material, and reading comprehension tasks. Conclusion: Print exposure and cortical volume atrophy may help explain variability in the language performance of nfvPPA individuals with similar age, education, disease duration, and cognitive ability.

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Altered speech-related cortical network in frontotemporal dementia

Cited by 7 publications

References 45 publications

Structural correlates of language processing in primary progressive aphasia

Structural correlates of language processing in primary progressive aphasia

Capturing Neuroplastic Changes after iTBS in Patients with Post-Stroke Aphasia: A Pilot fMRI Study

The Impact of Primary Progressive Aphasia on Picture Naming and General Language Ability

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