Altered Retinal Perfusion in Patients with Inactive Graves Ophthalmopathy Using Optical Coherence Tomography Angiography

Mihailovic, Nataša; Lahme, Larissa; Rosenberger, Friederike; Hirscheider, Michaela; Termühlen, Julia; Heiduschka, Peter; Grenzebach, Ulrike; Eter, Nicole; Alnawaiseh, Maged

doi:10.4158/ep-2019-0328

Cited by 27 publications

(24 citation statements)

References 25 publications

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“…However, Tehrani et al [34] found active and inactive TAO patients both had signi cantly lower super cial vessel density in the nasal parafoveal sector. Mihailovic et al [35] also showed inactive TAO patients had decreased vessel density in the super cial OCT angiogram. In these studies, the normal controls were not totally matched to the study population on several nonexperimental factors, such as age, sex, and axial length, which might at least partially explain the discrepancy.…”

Section: Discussionmentioning

confidence: 89%

Evaluation of retinal and choroidal variations in thyroid-associated ophthalmopathy using optical coherence tomography angiography

Qin

Cheng

et al. 2020

Preprint

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Background: To investigate the difference in retinal nerve fiber layer (RNFL) thickness, choroidal thickness (CT) and superficial retinal vessels between thyroid-associated ophthalmopathy (TAO) patients and healthy controls. To identify the potential influencing factors for these parameters and evaluate their diagnostic abilities in TAO.Methods: 20 active TAO patients, 33 inactive TAO patients and 29 healthy participants were enrolled. TAO patients were divided according to the clinical activity score (CAS). RNFL thickness and CT were measured by HD-OCT, while foveal avascular zone (FAZ), vascular density and perfusion density were measured by optical coherence tomography angiography (OCTA). SPSS software was used for statistical analysis.Results: Active TAO patients had thinner RNFL thickness than the other two groups (P<0.001, P<0.001). Both active and inactive TAO patients had significantly higher CT in the macular region (all P<0.05). The FAZ area in the active TAO group was significantly larger than the other two groups (P=0.045, P=0.001). The inactive TAO group had significantly higher vascular density than the other two groups (all P<0.05). With regard to the perfusion density, significant differences were observed in the temporal and inferior areas (P=0.045, P=0.001), as well as the average values (P=0.032). The FAZ area was positively correlated with intraocular pressure (r=0.274, P=0.013), while it was negatively correlated with axial length (r=-0.344, P=0.002). The vascular density and perfusion density were not significantly correlated with different clinical variables (all P>0.05). The AUC analysis indicated these parameters also exhibited a significant discriminatory power in TAO diagnosis.Conclusions: TAO patients had significant variations in RNFL thickness, choroidal thickness, FAZ area and superficial retinal vessels. These parameters appeared to be potential adjuncts in the evaluation of TAO patients.

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Section: Discussionmentioning

confidence: 89%

Evaluation of retinal and choroidal variations in thyroid-associated ophthalmopathy using optical coherence tomography angiography

Qin

Cheng

et al. 2020

Preprint

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“…OCTA can measure retinal vessel density, which is defined as the percentage of vessel area with blood flow over the total area measured. Various studies investigated the applicability of OCTA for patients with glaucoma [26], diabetes [27], age-related macular degeneration [28], and Graves' ophthalmopathy [11]. However, no previous research investigated the macular microvascular alterations in hypothyroid patients.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, we aimed to assess alterations in microvascular structure and perfusion of the macula in patients with treatment-naive, overt hypothyroidism using optic coherence tomography angiography (OCTA). There are many reports on retinal and choroidal changes related to Graves' Ophthalmopathy in the literature [11,12]. However, to the best of our knowledge, this is the first study assessing the macular perfusion changes in patients with hypothyroidism using OCTA.…”

Section: Introductionmentioning

confidence: 93%

Evaluation of macular perfusion in patients with treatment-naive overt hypothyroidism using optical coherence tomography angiography

Yıldız¹,

Erdal²,

Tarakçıoğlu³

et al. 2021

Journal of Surgery and Medicine

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“…Akpolat et al [33] demonstrated that the temporal and nasal parafoveal vessel density was significantly higher in inactive TAO group, which was consistent with our results. However, Tehrani et al [34] found active and inactive TAO patients both had significantly lower superficial vessel density in the nasal parafoveal [35] also showed inactive TAO patients had decreased vessel density in the superficial OCT angiogram. In these studies, the normal controls were not totally matched to the study population on several nonexperimental factors, such as age, sex, and axial length, which might at least partially explain the discrepancy.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of retinal and choroidal variations in thyroid-associated ophthalmopathy using optical coherence tomography angiography

Qin

Cheng

et al. 2020

BMC Ophthalmol

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Background To investigate the difference in retinal nerve fiber layer (RNFL) thickness, choroidal thickness (CT) and superficial retinal vessels between thyroid-associated ophthalmopathy (TAO) patients and healthy controls. To identify the potential influencing factors for these parameters and evaluate their diagnostic abilities in TAO. Methods Twenty active TAO patients, 33 inactive TAO patients and 29 healthy participants were enrolled. TAO patients were divided according to the clinical activity score (CAS). RNFL thickness and CT were measured by HD-OCT, while foveal avascular zone (FAZ), vascular density and perfusion density were measured by optical coherence tomography angiography (OCTA). SPSS software was used for statistical analysis. Results Active TAO patients had thinner RNFL thickness than the other two groups (P < 0.001, P < 0.001). Both active and inactive TAO patients had significantly higher CT in the macular region (all P < 0.05). The FAZ area in the active TAO group was significantly larger than the other two groups (P = 0.045, P = 0.001). The inactive TAO group had significantly higher vascular density than the other two groups (all P < 0.05). With regard to the perfusion density, significant differences were observed in the temporal and inferior areas (P = 0.045, P = 0.001), as well as the average values (P = 0.032). The FAZ area was positively correlated with intraocular pressure (r = 0.274, P = 0.013), while it was negatively correlated with axial length (r = − 0.344, P = 0.002). The vascular density and perfusion density were not significantly correlated with different clinical variables (all P > 0.05). The AUC analysis indicated these parameters also exhibited a significant discriminatory power in TAO diagnosis. Conclusions TAO patients had significant variations in RNFL thickness, choroidal thickness, FAZ area and superficial retinal vessels. These parameters appeared to be potential adjuncts in the evaluation of TAO patients.

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Altered Retinal Perfusion in Patients with Inactive Graves Ophthalmopathy Using Optical Coherence Tomography Angiography

Cited by 27 publications

References 25 publications

Evaluation of retinal and choroidal variations in thyroid-associated ophthalmopathy using optical coherence tomography angiography

Evaluation of retinal and choroidal variations in thyroid-associated ophthalmopathy using optical coherence tomography angiography

Evaluation of macular perfusion in patients with treatment-naive overt hypothyroidism using optical coherence tomography angiography

Evaluation of retinal and choroidal variations in thyroid-associated ophthalmopathy using optical coherence tomography angiography

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