Altered antioxidant status and lipid peroxidation in Indian patients with urothelial bladder carcinoma

Badjatia, Nitika; Satyam, Abhigyan; Singh, Prabhjot; Seth, Amlesh; Sharma, Alpana

doi:10.1016/j.urolonc.2008.12.010

Cited by 75 publications

(68 citation statements)

References 39 publications

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“…In our study, we found the difference of TAS, TOS and OSI between cancer patients and controls, statistically significant. The conflict may be ascribed to different methodology used in case of Badjatia et al (2010) although, very disputably, we find our result more reasonable, as the state of disease must be the failure of the organism to show a proportional respond to the increase in oxidative status. Measurement of OSI is extremely valuable as it informs about those oxidative stress not yet recognized or not easily measured.…”

Section: Discussionmentioning

confidence: 48%

“…Depending on these changes in albumin, serum albumin levels should be considered in IMA studies. Gecit et al (2012), and Badjatia et al (2010) showed increased oxidative stress and increased total anti-oxidant activity in bladder cancer patients. In our study, we found the difference of TAS, TOS and OSI between cancer patients and controls, statistically significant.…”

Section: Discussionmentioning

confidence: 93%

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Ischemia Modified Albumin Levels and Oxidative Stress in Patients with Bladder Cancer

Elli̇dağ¹,

Eren²,

Aydın³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Impaired oxidative/antioxidative status plays an important role in the pathogenesis of many diseases like cancer. The aim of this study was to evaluate the levels of the novel marker ischemia modified albumin (IMA) and albumin adjusted-IMA (Adj-IMA) in patients with bladder cancer (BC) as well as its association with total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI). Materials and Methods: Forty male patients with BC (mean age, 67.4±12 years) and forty age-sex matched healthy persons (mean age 56.0±1.7 years) were included in this study. Serum levels of IMA, TAS, TOS were analyzed and Adj-IMA and OSI was calculated. Results: Serum IMA, TOS and OSI values were significantly higher in patients with BC compared to controls (p<0.0001, p=0.01 and p=0.01, respectively), whereas TAS was significantly lower in BC patients (p=0.04). There was no significant difference for serum albumin-adjusted IMA levels between groups (p=0.4). Conclusions: In this study, it was found that there was an impaired oxidative/antioxidant status in favor of oxidative stress in BC patients. This observation was not confirmed by Adj-IMA calculation. There is no published report about serum concentrations of IMA in patients with BC. Further studies are needed to establish the relationship of IMA and oxidative stress parameters in BC and the significance of IMA to other cancers.

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Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 93%

Ischemia Modified Albumin Levels and Oxidative Stress in Patients with Bladder Cancer

Elli̇dağ¹,

Eren²,

Aydın³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Therefore, an increase of GSSG in cells and tissue can be a marker of oxidative stress. Studies indicate that GSH decreases in the blood of patients with breast cancer, thus acting as a biomarker of oxidative stress (Martínez Sarrasague., 2006;Valko et al, 2007;Badjatia et al, 2010;Vieira et al, 2011;Delwar et al, 2011).…”

Section: Biomarkers Of Oxidative Stressmentioning

confidence: 99%

Roles of Oxidative Stress in the Development and Progression of Breast Cancer

Nourazarian¹,

Kangari²,

Salmaninejad³

2014

Asian Pacific Journal of Cancer Prevention

150

108

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Oxidative stress is caused by an imbalance in the redox status of the body. In such a state, increase of free radicals in the body can lead to tissue damage. One of the most important species of free radicals is reactive oxygen species (ROS) produced by various metabolic pathways, including aerobic metabolism in the mitochondrial respiratory chain. It plays a critical role in the initiation and progression of various types of cancers. ROS affects different signaling pathways, including growth factors and mitogenic pathways, and controls many cellular processes, including cell proliferation, and thus stimulates the uncontrolled growth of cells which encourages the development of tumors and begins the process of carcinogenesis. Increased oxidative stress caused by reactive species can reduce the body's antioxidant defense against angiogenesis and metastasis in cancer cells. These processes are main factors in the development of cancer. Bimolecular reactions cause free radicals in which create such compounds as malondialdehyde (MDA) and hydroxyguanosine. These substances can be used as indicators of cancer. In this review, free radicals as oxidizing agents, antioxidants as the immune system, and the role of oxidative stress in cancer, particularly breast cancer, have been investigated in the hope that better identification of the factors involved in the occurrence and spread of cancer will improve the identification of treatment goals.

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“…34 Through altered antioxidant status, the metabolic shift of lipogenesis might be one important factor for tumor development and growth in BC patients. 35 In addition, as important products of lipids metabolism, ketone bodies (e.g. acetoacetate) were observed with elevated serum levels in BC patients, indicative of enhanced lipogenesis.…”

Section: Lipids and Ketone Bodies Metabolismmentioning

confidence: 99%