Alterations of serum and saliva oxidative markers in patients with bronchial asthma

Abboud, Muayad M.; Al-Rawashde, Futoon Abedrabbu; Al-Zayadneh, Enas

doi:10.1080/02770903.2021.2008426

Cited by 5 publications

(7 citation statements)

References 34 publications

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“…A comparison of the S-MDA levels between exacerbations and periods of stability was performed by some authors, finding higher levels during acute attacks in both adult [ 77 , 78 ] and paediatric [ 79 ] cohorts. Finally, even in the studies lacking definitions of the phenotype and clinical period of asthma patients, the S-MDA levels were higher in the patients than in the controls [ 80 , 81 ], although no correlation with lung function was found in children [ 82 ]. Moreover, one of these studies [ 80 ] showed increased MDA levels even in salivary samples.…”

Section: Resultsmentioning

confidence: 99%

Malondialdehyde as a Potential Oxidative Stress Marker for Allergy-Oriented Diseases: An Update

et al. 2023

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Malondialdehyde (MDA) is a compound that is derived from the peroxidation of polyunsaturated fatty acids. It has been used as a biomarker to measure oxidative stress in various biological samples in patients who are affected by a wide range of diseases. The aim of our work is to provide an updated overview of the role of MDA as a marker of oxidative stress in allergy-related diseases. We considered studies involving both paediatric and adult patients affected by rhinitis, asthma, urticaria and atopic dermatitis. The measurement of MDA was performed on different types of samples. The reported data highlight the role of serum MDA in inflammatory airway diseases. According to the literature review, the oxidative stress status in asthmatic patients, assessed via MDA determination, appears to worsen in the presence of other allergic airway diseases and in relation to the disease severity. This suggests that MDA can be a suitable marker for monitoring the disease status. However, there are several limitations in the considered studies due to the different samples used and the lack of phenotyping and description of the clinical period of patients examined. In cutaneous allergic diseases, the role of MDA is controversial because of the smallness of the studies and the heterogeneity of the samples and patients.

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Section: Resultsmentioning

confidence: 99%

Malondialdehyde as a Potential Oxidative Stress Marker for Allergy-Oriented Diseases: An Update

et al. 2023

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“…The present study demonstrates an increase in the generation of amino acid HP in the peripheral blood of asthmatic patients, reflecting an enhanced systemic oxidative stress response in that disease. In asthma, increased ROS formation by inflammatory cells has already been described in both the airways and systemic circulation [ 5 , 13 , 18 ]. Here, we show that it can be assessed reliably in the peripheral blood by using a recently developed technically undemanding real-time CBA assay [ 21 , 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…For example, patients with severe asthma show decreased plasma activity of Lp-PLA 2 [ 11 ]. On the contrary, others point to the upregulation of antioxidative mechanisms, albeit with still an overwhelming prooxidative capacity [ 3 , 12 , 13 ]. Nevertheless, the role of oxidative stress in asthma pathology and airway remodeling has not been comprehensively studied, including how it impacts endothelial injury and early atherosclerosis [ 14 ] and increases the risk of prothrombotic and cardiovascular events, as previously reported in that disease [ 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…Numerous studies on asthma indicate an increased prooxidative potential of peripheral blood leukocytes, mainly neutrophils, and upregulation of oxidative biomarkers in airways, e.g., nitric oxide, or in circulation, e.g., malondialdehyde and uric acid [ 3 , 5 , 13 , 18 ]. However, scarcer data analyzed oxidative stress globally in circulating blood, probably due to the lack of reliable research methods that could be successfully applied to serum or plasma samples.…”

Section: Introductionmentioning

confidence: 99%

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Increased Oxidative Stress in Asthma—Relation to Inflammatory Blood and Lung Biomarkers and Airway Remodeling Indices

et al. 2022

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Airway inflammation in asthma is related to increased reactive oxygen species generation, potentially leading to tissue injury and subsequent airway remodeling. We evaluated oxidative stress in peripheral blood from asthmatic subjects (n = 74) and matched controls (n = 65), using recently developed real-time monitoring of the protein hydroperoxide (HP) formation by the coumarin boronic acid (CBA) assay. We also investigated the relation of the systemic oxidative stress response in asthma to disease severity, lung function, airway remodeling indices (lung computed tomography and histology), and blood and bronchoalveolar lavage fluid (BAL) inflammatory biomarkers. We documented enhanced systemic oxidative stress in asthma, reflected by 35% faster and 58% higher cumulative fluorescent product generation in the CBA assay (p < 0.001 for both). The dynamics of HP generation correlated inversely with lung function but not with asthma severity or histological measures of airway remodeling. HP generation was associated positively with inflammatory indices in the blood (e.g., C-reactive protein) and BAL (e.g., interleukin [IL]-6, IL-12p70, and neutrophil count). Bronchial obstruction, thicker airway walls, increased BAL IL-6, and citrullinated histone 3 in systemic circulation independently determined increased HP formation. In conclusion, a real-time CBA assay showed increased systemic HP generation in asthma. In addition, it was associated with inflammatory biomarkers, suggesting that proper disease control can also lead to a decrease in oxidative stress.

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“…An important relationship has been established between OS and various diseases, and this stressor is now at the forefront of research to elucidate pathogenesis. Indeed, OS has been linked to various diseases, including rheumatoid arthritis (RA) [ 9 , 10 ], Alzheimer’s disease (AD) [ 11 , 12 ], Parkinson’s disease (PD) [ 12 , 13 , 14 ], amyotrophic lateral sclerosis (ALS) [ 15 , 16 ], cardiovascular disease [ 17 ], allergies [ 18 , 19 ], immune disorders, metabolic dysfunction [ 20 ], diabetes [ 21 , 22 ], liver diseases [ 23 ], and cancer [ 24 , 25 ]. This paper presents a historical overview of redox biology and the nature of ROS and free radicals.…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress and Bio-Regulation

Yoshikawa,

You

2024

IJMS

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Reactive oxygen species (ROS) and free radicals work to maintain homeostasis in the body, but their excessive production causes damage to the organism. The human body is composed of a variety of cells totaling over 60 trillion cells. Each cell performs different functions and has a unique lifespan. The lifespan of cells is preprogrammed in their genes, and the death of cells that have reached the end of their lifespan is called apoptosis. This is contrary to necrosis, which is the premature death of cells brought about by physical or scientific forces. Each species has its own unique lifespan, which in humans is estimated to be up to 120 years. Elucidating the mechanism of the death of a single cell will lead to a better understanding of human death, and, conversely, the death of a single cell will lead to exploring the mechanisms of life. In this sense, research on active oxygen and free radicals, which are implicated in biological disorders and homeostasis, requires an understanding of both the physicochemical as well as the biochemical aspects. Based on the discussion above, it is clear to see that active oxygen and free radicals have dual functions of both injuring and facilitating homeostasis in living organisms.

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Alterations of serum and saliva oxidative markers in patients with bronchial asthma

Cited by 5 publications

References 34 publications

Malondialdehyde as a Potential Oxidative Stress Marker for Allergy-Oriented Diseases: An Update

Malondialdehyde as a Potential Oxidative Stress Marker for Allergy-Oriented Diseases: An Update

Increased Oxidative Stress in Asthma—Relation to Inflammatory Blood and Lung Biomarkers and Airway Remodeling Indices

Oxidative Stress and Bio-Regulation

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