Malondialdehyde as a Potential Oxidative Stress Marker for Allergy-Oriented Diseases: An Update

Abstract

Malondialdehyde (MDA) is a compound that is derived from the peroxidation of polyunsaturated fatty acids. It has been used as a biomarker to measure oxidative stress in various biological samples in patients who are affected by a wide range of diseases. The aim of our work is to provide an updated overview of the role of MDA as a marker of oxidative stress in allergy-related diseases. We considered studies involving both paediatric and adult patients affected by rhinitis, asthma, urticaria and atopic dermatitis. The measurement of MDA was performed on different types of samples. The reported data highlight the role of serum MDA in inflammatory airway diseases. According to the literature review, the oxidative stress status in asthmatic patients, assessed via MDA determination, appears to worsen in the presence of other allergic airway diseases and in relation to the disease severity. This suggests that MDA can be a suitable marker for monitoring the disease status. However, there are several limitations in the considered studies due to the different samples used and the lack of phenotyping and description of the clinical period of patients examined. In cutaneous allergic diseases, the role of MDA is controversial because of the smallness of the studies and the heterogeneity of the samples and patients.

Effects of exposing Japanese quail eggs to a low dose of gamma radiation and in ovo feeding by two sources of trace elements on embryonic development activities

“…For this reason, TE plays a vital role in the biosynthesis and catalytic process of MBP and metalloenzymes, which regulate the candidate roles in structural and functional enzymes of biological pathways ( Talukder, 2021 ; Marikar and Zi-Chun, 2022 ). The results of the present study showed that serum MDA content was significantly decreased in the TEM/GR group in response to reduced lipid peroxidation, which is a marker of homeostasis disturbances and cellular oxidative stress and is known to possess mutagenic and toxic effects ( Cordiano et al, 2023 ). CAT activity was elevated in the TEM/GR group, considering that it is a major player in the cellular antioxidant network and is involved in many cytosolic and nuclear proteins that appear to be essential for protein functions ( Baker et al, 2023 ).…”

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“…MDA, a common oxidation product of lipids, is often utilized as a biomarker of oxidative damage in the body [ 16 , 20 ]. Increasing MDA levels in the body can be caused by chronic inflammation processes that can trigger prolonged lipid oxidation [ 16 ].…”

Vinpocetine alleviated alveolar epithelial cells injury in experimental pulmonary fibrosis by targeting PPAR-γ/NLRP3/NF-κB and TGF-β1/Smad2/3 pathways

“…Several studies have reported that oxidative stress was associated with the development of alveolar injury, inflammation, and fibrosis 79 . MDA can influence the inflammatory response of the innate immune system through several signaling pathways, including protein kinase-C, p38-MAPK, ERK1/2, and NF-kB 80 . Oxidative stress might promote a fibrotic microenvironment, where fibroblasts were resistant to the damaging effects of ROS in PF, but epithelial cells were relatively more sensitive to oxidative stress.…”