1986
DOI: 10.1002/jbmr.5650010404
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Alterations in hormone-sensitive adenylate cyclase of cloned rat osteosarcoma cells during long-term culture

Abstract: The hormone-sensitive adenylate cyclase system of a cloned bone cell line (UMR-106) derived from a rat osteosarcoma was compared in preparations from cells of early passages (less than 50) and cells maintained in continuous culture for over two years (late passages). Late passage cells showed greater calcitonin (CT)-stimulated adenylate cyclase activity than did early passages, whereas stimulation by PTH and the beta-adrenergic agonist isoproterenol decreased in late passages. Hormone concentrations giving hal… Show more

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Cited by 14 publications
(1 citation statement)
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“…Our data describe similar initial attachment to smooth and roughened titanium surfaces but a distinct reduction in attachment to NCPIT surfaces by osteoblasts (similar to other studies), whereas osteosarcoma (UMR‐106 cells) displayed a pronounced increase in migration. Although UMR‐106 cells have been used for years as a model system for osteoblast differentiation, 33‐36 our data indicate that the UMR cells do not represent a good model system for examining osteoblast interaction with titanium surfaces.…”
Section: Discussionmentioning
confidence: 83%
“…Our data describe similar initial attachment to smooth and roughened titanium surfaces but a distinct reduction in attachment to NCPIT surfaces by osteoblasts (similar to other studies), whereas osteosarcoma (UMR‐106 cells) displayed a pronounced increase in migration. Although UMR‐106 cells have been used for years as a model system for osteoblast differentiation, 33‐36 our data indicate that the UMR cells do not represent a good model system for examining osteoblast interaction with titanium surfaces.…”
Section: Discussionmentioning
confidence: 83%