1988
DOI: 10.1002/jbmr.5650030313
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Consistent patterns of changing hormone responsiveness during continuous culture of cloned rat calvaria cells

Abstract: The loss of responsiveness to hormones in cell populations is a fundamental problem in cell biology and aging. We have studied this process in cloned rat calvaria (RC) bone cell populations maintained in exponential growth in long-term culture in alpha-minimal essential medium supplemented with fetal bovine serum. At various times after cloning, the populations were tested for their ability to respond to parathyroid hormone (PTH), prostaglandin E2 (PGE2), and L-isoproterenol (IPT) with an increase in intracell… Show more

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Cited by 19 publications
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