2013
DOI: 10.1097/sla.0b013e31826e1846
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Alterations in Gut Hormones After Laparoscopic Sleeve Gastrectomy

Abstract: LSG markedly improved glucose homeostasis and generated significant changes in ghrelin, PP, PYY, GLP-1, amylin, and leptin levels. These multiple hormonal actions may have several beneficial effects on the underlying mechanism of weight loss, demonstrating that LSG could be more than just a restrictive bariatric operation.

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Cited by 115 publications
(41 citation statements)
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“…9,11 Our results showed that extension of food contact time with the area of the terminal ileum occurs after SG (with an earlier entry and later exit), thus possibly accounting for an early and prolonged stimulation of intestinal L cells producing incretins capable of ameliorating glycemic control. This implication is confirmed by findings of our team and others showing increased postprandial levels of peptide-YY 23,35 and glucagon-like peptide-1 35 after SG.…”
Section: Discussionsupporting
confidence: 91%
See 1 more Smart Citation
“…9,11 Our results showed that extension of food contact time with the area of the terminal ileum occurs after SG (with an earlier entry and later exit), thus possibly accounting for an early and prolonged stimulation of intestinal L cells producing incretins capable of ameliorating glycemic control. This implication is confirmed by findings of our team and others showing increased postprandial levels of peptide-YY 23,35 and glucagon-like peptide-1 35 after SG.…”
Section: Discussionsupporting
confidence: 91%
“…29 Finally in this obscure field of uncertainty, the alterations resulting in the gut hormone profile and leptin levels after SG 23,35 could play an important role in the interpretation of our results, as it is known that gastrointestinal hormones are closely related to appetite control 45 and to gastrointestinal motility regulation. [46][47][48][49][50] It has been reported that ghrelin levels 23 as well as fasting and postprandial leptin and amylin levels 35 are reduced after SG in morbidly obese patients, while postprandial glucagon-like peptide-1 35 and peptide-YY levels 23,35 are increased. From the above-mentioned observations, only the alterations in postoperative leptin and amylin levels could account for the enhanced gastric and intestinal motility, 48,49 but further studies are needed to prove this.…”
Section: Discussionmentioning
confidence: 79%
“…174,175 However, it is unclear whether this contributes to weight loss, dietary intake or glycemic control relative to concomitant hormonal changes in GLP-1, GIP, and other hormones.…”
Section: Lessons From Effects Of Bariatric Surgery On Gut Hormones Amentioning
confidence: 99%
“…Other factors that have been hypothesized to be altered after one or more of these procedures include prandial secretion of cholecystokinin (Jacobsen et al, 2012; Peterli et al, 2012), glucose inhibitory peptide (Lee et al, 2013; Romero et al, 2012), glucagon (Romero et al, 2012), GLP-2 (Jacobsen et al, 2012; Romero et al, 2012), peptide YY (Dimitriadis et al, 2013; Peterli et al, 2009), and perhaps others (Dimitriadis et al, 2013; Santoro et al, 2008). Determining the relative contribution of these different factors to surgical benefits on glucose tolerance and weight loss remains an important research goal.…”
Section: Glp-1mentioning
confidence: 99%