Alpha-Fetoprotein in Twin Pregnancy

Alpha‐Fetoprotein (AFP) Levels in Maternal Serum in Early Multiple Pregnancies

“…A similar tendency had previously been demonstrated to prevail during late pregnancy (Ishiguro, 1973(Ishiguro, , 1975Garoff & Seppala, 1973).…”

Maternal serum alpha‐feto‐protein: Its value in antenatal diagnosis of genetic disease and in obstetrical‐gynaecological care

“…In 10 out of 11) twin pregnancies (71.&), the maternal AFF values were significantly higher than the normal range for single pregnancies and approximately twice as high as the normal average values in single pregnancies (Ishiguro, 1973(Ishiguro, , 1975. The maternal AFP values were above the normal 50th centile in all 19 twin pregnancies, between the 50th and 97.5th centiles in one pregnancy with triplets and above the 97.5th centile (upper nonual level) in one pregnancy with quadruplets (Garoff and Seppal;, 1973).…”

“…Maternal plasma AE' P l e v e l s i n normal pregnancy. AFP are twice as high as in singleton pregnancies (Ishiguro, 1973; of synthesis of AFP (as shown by the correlation with the number of fetuses) is an important factorthe fetus being the source of AFP.…”