Maternal serum alpha‐feto‐protein: Its value in antenatal diagnosis of genetic disease and in obstetrical‐gynaecological care

Alpha-fetoprotein and its value for predicting pregnancy outcomes � a re-evaluation

“…The data which is used up to present in textbooks and in internet (e.g. http://www.glowm.com/resources/glowm/cd/index.html) is based on a work from 1977 (8). The data published there is included in Table 1, and it is striking that AF-AFP concentrations there are always about double as high as in the data obtained in this study in >3,000 cases.…”

Development of an Active Site Peptide Analog of α-Fetoprotein That Prevents Breast Cancer

“…The concentration of these analytes in amniotic fluid is gestational age-dependent, normally attaining peak values of 600 pg/mL for estradiol (6) and 10 mg/mL for AFP (7). In fetal plasma, AFP concentration attains 1 to 4 mg/mL (7).…”

“…The concentration of these analytes in amniotic fluid is gestational age-dependent, normally attaining peak values of 600 pg/mL for estradiol (6) and 10 mg/mL for AFP (7). In fetal plasma, AFP concentration attains 1 to 4 mg/mL (7). Despite exposure to these high plasma levels of estrogen and the presence of estrogen receptors (8,9), fetal mammary epithelial cells do not respond (10) to estrogen perhaps because of an anti-estrogenic property of AFP (the only feasible protein component of amniotic fluid that could provide such a property).…”

Relationship between some obstetric landmarks and the concentration of alpha-fetoprotein in maternal blood

“…· j--+· + \H οι · Λ ι ^u 4.· · an altered fetal-maternal barrier, prejudicing investigators [7,8], since the larger the antigenic n u · r Λ f * \ i*u ^ ΙιΛ ι ^-, 6 ,.…”

“…This variability may be due to a number of factors. Some of these factors were described by HABIB [6], but in the whole they are not well investigated. The present report attempts to study the variation of the levels of AFP in pregnancy serum with some obstetric landmarks, in the hopes that part of this variability could be clarified.…”