Alopecia Areata Thyroid Disease and Autoimmunity

Abstract

SUMMARY.— The incidence of thyroid disease in patients with alopecia areata was greater than in patients with psoriasis and also greater than in a control series of the general population. There was also an increased incidence of alopecia areata and diabetes mellitus in the relatives of patients with alopecia areata. No significant difference was found in the incidence of thyroglobulin and thyroid complement‐fixing antibodies in patients with alopecia areata as compared with a general practice population. A negative association between psoriasis and thyroid antibodies was demonstrated.

Epidemiological and clinical characteristics of alopecia areata: an observational study from South India

“…Incidence of thyroid disease in AA ranged from 8% to 33%. 14,19 We had a single subject with associated thyroid abnormality. Our findings agree with studies from a number of countries in this association.…”

Medium-dose prednisolone pulse therapy in alopecia areata

“…3 Although the exact etiology of AA is still unknown, there is accumulated evidence that supports a hereditary susceptibility and an autoimmune pathogenesis, such as a familial history in 4-27%, 4,5 and the increased frequency of other autoimmune diseases, particularly autoimmune thyroid disease, and of organspecific autoantibodies in patients with AA [6][7][8] as well as the presence of CD8 + T cells next to the hair follicles. 9,10 Among the various immunomodulatory treatments that have been used to induce remission in AA, systemic corticosteroids have been administered in extensive or rapidly progressive AA and in alopecia totalis/universalis.…”

Presence of Autoimmune Diseases in Alopecia Areata Patients and Their Families and Its Effect on Prognosis

“…İstatiksel anlamlılık p<0,05 ve iki yönlü kabul edildi. (17)(18)(19)(20)(21)(22). Cinsiyet ilişkisinde anti tiroid antikor pozitifliğini kadınlarda anlamlı olarak yüksek bulduk (p=0,017), fakat literatürde anlamsız sonuçlar da bildirilmiştir (19).…”

“…(10) bu oranı %3,9 bildirmiştir. Yayınlarda AA'da bildirilen pernisiyöz anemi hiçbir hastamızda saptanmadı (13,16,20). Anti gastrik pariyetal antikoru %2,2 idi ve literatürden düşük bulundu (18,(21)(22)(23)(24).…”