Alopecia areata: A Clinical Study

Weert, J. De; Temmerman, Liesbeth; Kint, A

doi:10.1159/000249708

Cited by 54 publications

(26 citation statements)

References 8 publications

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“…This frequency was significantly higher than that found in the normal population in our area (11.9%; p =0.0212). These patients had a significantly higher incidence of vitiligo in their families (76.9 vs. 29.7% of the nonatopic; p<0.025), an earlier onset (14.1 vs. 24 years of the nonatopic) and a rapid worsening of the disease.Vitiligo is frequently associated with alopecia areata 11, 2]; this in turn is frequently associated with atopy [3][4][5][6][7]; moreover, the atopic type of alopecia areata of Ikeda's classification |4| is characterized by an earlier onset [4,8], a worse prognosis and response to topical immunomodulators [8], Association between vitiligo and atopic manifestations has only indirectly been reported in a study of alopecia areata [3], and more recent studies of atopic dermatitis do not report a significantly increased frequency of the asso ciation of vitiligo and atopic dermatitis [9J.We searched for atopy in patients suffering from vit iligo and correlated its presence with some clinical param eters of the latter. …”

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confidence: 99%

Prevalence of Atopy in Vitiligo

et al. 1991

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59 patients suffering from vitiligo were investigated anamnestically and clinically with intradermal (prick tests) and laboratory tests (RAST and total IgE count) for the presence of atopy. Clinical manifestations (allergic rhinitis, asthma) and intense positive prick tests and RAST with an increase in total IgE count were found in 13 patients (22%). This frequency was significantly higher than that found in the normal population in our area (11.9%; p = 0.0212). These patients had a significantly higher incidence of vitiligo in their families (76.9 vs. 29.7% of the non-atopic; p < 0.025), an earlier onset (14.1 vs. 24 years of the nonatopic) and a rapid worsening of the disease.

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confidence: 99%

Prevalence of Atopy in Vitiligo

et al. 1991

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“…Pozitif aile öyküsü yapılan yayınlarda %4.6 ile %42 arasında değişmektedir (5,16,17). Küçük yayınlarda aile öyküsü görülme sıklığı daha fazla bulunmuştur (18)(19)(20). Bizim çalışmamızda 54 AA'lı hastanın 16'sında (%29.6) aile öyküsü mevcuttu.…”

Section: Discussionunclassified

Clinical Features and Prognosis of Juvenil Alopecia Areata Patients

Özden¹,

Bayramoglu²,

Aydın³

et al. 2010

Turk J Dermatol

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Objective: Although alopecia areata (AA) affects both adults and children, there is limited information about juvenile AA. In this study the properties of juvenile AA, associated diseases and trigger factors were reviewed. Material ve Methods:We have examined the data of 54 AA patients under 16 years of age. We have re-contacted these patients and evaluated the course of the features of the disease and collected information about triggering factors, starting age, attack number, alopecia type, severity and localization of disease duration, full blood count, biochemistry and thyroid function tests, family history and the prognosis in the following years. Results: We could not detect any significant relationship between the presence of a trigger factor and severity of the clinical picture. Similarly, no relationship between duration of illness, gender, and the trigger factor was found. Seven (12.96%) patients had an underlying endocrinological disease. There was no significant relationship between the severity of clinical condition and the endocrine disease. Sixteen patients (29.6%) had a family history of AA with 1.2. or 3 degree relatives. Conclusion: While disease duration, gender and trigger factors did not have a significant relationship, family history was found to affect clinical severity. Another striking result was the stable severity in the presence of trigger factors. (Turk J Dermatol 2010; 4: 60-5)

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“…24,32 Juvenile onset AA, also characterized by a bad natural history and poor response to treatment (41.5%), confirms earlier studies. [23][24][25]27,28,[42][43][44] Atopy in AA has been reported to be one of the bad prognostic factors. 24,33,34 In contrast, this study showed no statistically significant differences between the atopic and nonatopic groups according to response rate and severity (Tables 1 and 3).…”

Section: Discussionmentioning

confidence: 99%