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Foks, Henryk; Mieczkowska, J.; Janowiec, M; Zwolska, Zofia; Andrzejczyk, Z

doi:10.1023/a:1020681604052

Cited by 29 publications

(18 citation statements)

References 4 publications

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“…However, the excess of amine led to the formation of undesired amidine by-product by means of nucleophilic addition of amine to carbonitrile group (c). This type of reaction concerning pyrazine carbonitrile group was previously described by Foks 14,15 and used by Shirai. 16 In our study, this reaction appeared mainly with primary amines.…”

Section: Chemistrymentioning

confidence: 99%

Synthesis and antimycobacterial properties of N-substituted 6-amino-5-cyanopyrazine-2-carboxamides

Zítko

Doležal

Svobodová³

et al. 2011

Bioorganic & Medicinal Chemistry

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Section: Chemistrymentioning

confidence: 99%

Synthesis and antimycobacterial properties of N-substituted 6-amino-5-cyanopyrazine-2-carboxamides

Zítko

Doležal

Svobodová³

et al. 2011

Bioorganic & Medicinal Chemistry

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“…Syntheses of amidrazones 1, 3-5 were described elsewhere [24,25]. Reaction yields, physical constants, and spectral data of the compounds are given in Tables 1 and 2.…”

Section: Methodsmentioning

confidence: 99%

Studies on pyrazine derivatives LII: Antibacterial and antifungal activity of nitrogen heterocyclic compounds obtained by pyrazinamidrazone usage

Foks

Balewski

Gobis

et al. 2011

Heteroatom Chemistry

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“…The high antiviral activity of the O-ethers of pyrimidine oximes 119 against HIV-1 was also discovered [164,165]. Various pyrazine oximes displayed antitubercular activity [166,167]. In addition trypanocidal activity was found in the O-ethers of piperazine amidoximes [168], and antimalarial activity was found in purine oximes [169].…”

Section: Bactericidal Anticancer and Antiviral Activitymentioning

confidence: 99%

Oximes of six-membered heterocyclic compounds with two and three heteroatoms. II.* Reactions and biological activity (review)

Абеле

Golomba

et al. 2010

Chem Heterocycl Comp

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Data on the reactions of pyridazine, pyrimidine, pyrazine, triazine, oxazine, thiazine, oxadiazine, and thiadiazine aldoximes, ketoximes, and amidoximes and their derivatives are reviewed. The synthesis of new heterocycles based on the oximes of six-membered heterocyclic compounds with two and three heteroatoms is considered separately. The principal results of research into the biological activity of these oximes and their ethers are also presented.The oximes of six-membered heterocyclic compounds with two and three heteroatoms are widely used as intermediates in fine organic synthesis. Their production methods and structural features were examined in the review [1]. In this article we discuss the reactions of pyridazine, pyrimidine, pyrazine, triazine, oxazine, thiazine, oxadiazine, and thiadiazine aldoximes, ketoximes, and amidoximes and their derivatives. Methods for the synthesis of new heterocyclic systems from the derivatives of these oximes are considered in a separate section. In the last section some results from investigation of the biological activity of the ethers of these oximes are considered.

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Cited by 29 publications

References 4 publications

Synthesis and antimycobacterial properties of N-substituted 6-amino-5-cyanopyrazine-2-carboxamides

Synthesis and antimycobacterial properties of N-substituted 6-amino-5-cyanopyrazine-2-carboxamides

Studies on pyrazine derivatives LII: Antibacterial and antifungal activity of nitrogen heterocyclic compounds obtained by pyrazinamidrazone usage

Oximes of six-membered heterocyclic compounds with two and three heteroatoms. II.* Reactions and biological activity (review)

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