Allium sativum, a potential phytopharmacological source of natural medicine for better health

Gudalwar, Bhushan R.; Nimbalwar, Minakshee G.; Panchale, Wrushali A.; Wadekar, Ashish B.; Manwar, Jagdish V.; Bakal, Ravindra L.

doi:10.30574/gscarr.2021.6.3.0049

Cited by 18 publications

(3 citation statements)

References 85 publications

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“…In the last decades, the popularity of organosulfur compounds present in the extract of garlic has increased tremendously (Hart et al, 2010). It is documented in many studies that A. sativum and its organosulfur constituents have the characteristics of antioxidants, antibacterial, anti-inflammatory, immuno-modulatory, antifungal, as well as protective properties for the cardiovascular and digestive systems including hepatoprotection, anticancer, antidiabetic, anti-obesity, renal and neuroprotective properties (Gudalwar et al, 2021). Garlic as a good source of sulfur-containing bioactive compounds can be used in the formulation of food and nutraceutical products for the control and prevention of various diseases (Mikaili et al, 2013).…”

Section: Chemical Composition Of Garlicmentioning

confidence: 99%

Therapeutic Potential of Garlic (Allium sativum) in Ruminants

Munir,

Shakoor,

Sindhu

et al. 2023

Complementary and Alternative Medicine: One Health Perspective

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Parasites pose a potential threat to livestock farming by inflicting heavy economic losses, thus, emphasizing their control for successful farming. Conventionally, this control has long been achieved through anti-parasitic drugs. However, due to the emergence of resistance in parasites against these drugs and the presence of their residues in animal products, there is an increased interest in searching for safe and effective alternatives like garlic. Garlic is a natural spice that is enriched with many health-beneficial compounds. Historically, it has long been used as a natural remedy for certain diseases. Recent research on garlic, especially its organosulfur compounds, has shown a wide range of therapeutic effects. It bears antioxidant, antiparasitic, antihypertensive, and antimicrobial properties. It is effective against various protozoa and helminths of ruminants. It modulates the gastrointestinal environment and works as a growth-promoting agent in ruminants. However, there exist some barriers to the practical application of garlic in ruminants which are also discussed in this chapter.

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Section: Chemical Composition Of Garlicmentioning

confidence: 99%

Therapeutic Potential of Garlic (Allium sativum) in Ruminants

Munir,

Shakoor,

Sindhu

et al. 2023

Complementary and Alternative Medicine: One Health Perspective

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“…Garlic contains enzymes, minerals, and vitamins ( Shang et al, 2019 ). Bioactive compounds in garlic have shown antioxidant, anticancer, antidiabetic, neuroprotective, and hepatoprotective effects on the cardiovascular, renal, and digestive systems ( Gudalwar et al, 2021 ; El et al, 2021 ).…”

Section: Background Informationmentioning

confidence: 99%

Role of oral phytogenic supplementation to protect cardiac, hepatic, nephrotic, and splenic oxidative stress in broiler chickens

Abubakar,

Uchechi,

Olayinka Abosede

et al. 2023

Translational Animal Science

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This study investigated the effects of adding essential oils of garlic, ginger, turmeric and cinnamon to drinking water on cardiac, hepatic, nephrotic, splenic oxidative status of broiler chickens. A batch of 200 one-day old Arbo acre broiler chicks was administered with Control (Water: no additive), 30ml/L of cinnamon, ginger, turmeric or garlic essential oils in drinking water for 42 days. At day 43, 3 broiler chickens/replicates were sampled randomly, sacrificed and eviscerated. The hearts, spleens, kidneys and livers were excised and assayed for glutathione peroxidase, total antioxidant activity, catalase, superoxide dismutase and lipid peroxidation using standard protocols. In spleen broiler chickens, all additive essential oils increased (p<0.05) total antioxidant activity. Catalase, superoxide dismutase and glutathione peroxidase significantly increased (p<0.05) in garlic, ginger and turmeric essential oils except cinnamon. In kidney broiler chickens, lipid peroxidation was significantly reduced (p<0.05) in all the additive essential oils. Garlic, cinnamon and ginger essential oils increased (p<0.05) catalase, superoxide dismutase and glutathione peroxidase in kidney broiler chickens. In liver broiler chickens, lipid peroxidation and glutathione peroxidase were higher (p<0.05) in cinnamon essential oil than other additive essential oils. Superoxide dismutase and catalase were higher (p<0.05) in turmeric essential oils. In heart broiler chickens, all the additive essential oils significantly decreased (p<0.05) lipid peroxidation and increased (p<0.05) total antioxidant activity. In conclusion, oral garlic, turmeric and ginger essential oils supplementation did not reduce lipid peroxidation in spleen whereas cinnamon essential oil caused lipid peroxidation in liver of broiler chickens.

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“…In other research, garlic has shown the ability to reduce nitric oxide (NO) and prostaglandin E2 (PGE2) production by decreasing the expression of inducible NO synthase [iNOS] and cyclooxygenase-2 [COX2] ( 19 ). Various diseases will cause tissue injury; they are related to inflammation reactions.…”

Section: Introductionmentioning

confidence: 99%

Anti Inflammatory Action of Allium Sativum Ethanol Extract to Prevent Lung Damage in Smoker Rat Model

Maya¹,

Sari²,

Machrina³

et al. 2023

Med Arch

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Background: Smoking is the leading cause of death in worldwide and is known as one of the risk factors in the development and pathogenesis of several diseases and most are respiratory and cardiovascular diseases. Secondhand smoke (SHS) exposure is associated with negative health consequences including respiratory tract infection, asthma, and cancer. One of the pathogenesis that has known to cause these diseases is inflammation. Garlic (Allium sativum) is a medicinal herb that contains Allicin and other active constituents that are known to have anti-inflammatory ability by suppressing the expression and production of proinflammatory cytokines that will cause inflammation. Objective: The aim of this study is; to analyze the anti-inflammatory action of Allium sativum ethanol extract to prevent lung damage in the smoker rat model. Methods: This is a case-control study with five groups of rats each group contains of three rats. The five groups were negative control (KN), 10 days (10d) smoker (K1), 20 days (20d) smoker (K2), 20d smoker treated with Allium sativum for 10 days (K3) and 20d smoker treated with Allium sativum for 20 days (K4). After 20 days all animals were sacrificed and histological preparation of lung organs was observed under a microscope with 100 dan 400 times magnification and then captured by photomicrograph for analyzed. Results: There were improvements in lung structure both in group K3 and K4 . there was a decrease of leucocytes and inflammatory cells infiltration that covered almost all alveolar surface to 10-20% surface area and the dilated alveoli decrease from more than 50% to less than 30% area. The bronchus was clean in both two groups compared to the groups that were not treated with Allium sativum Conclusion: This study shows that Allium sativum ethanol extract has the ability to prevent lung damage in the smoker rat model.

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Allium sativum, a potential phytopharmacological source of natural medicine for better health

Cited by 18 publications

References 85 publications

Therapeutic Potential of Garlic (Allium sativum) in Ruminants

Therapeutic Potential of Garlic (Allium sativum) in Ruminants

Role of oral phytogenic supplementation to protect cardiac, hepatic, nephrotic, and splenic oxidative stress in broiler chickens

Anti Inflammatory Action of Allium Sativum Ethanol Extract to Prevent Lung Damage in Smoker Rat Model

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