Allergic Rhinitis and its Impact on Asthma (ARIA)

Bousquet, Jean

doi:10.1046/j.1472-9725.2003.00063.x

Cited by 443 publications

(719 citation statements)

References 3 publications

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“…The related research about allergen-induced respiratory symptoms and molecular mechanisms of allergic reactions have been conducted extensively, which has further led to the clinical practice of allergen-specific immunotherapy for respiratory allergies worldwide (Hurwitz, 1953). The worldwide delivery of guidelines and investigations via those organizations such as Allergic Rhinitis and its Impact on Asthma (ARIA), Global Initiative for Asthma (GINA), and GA 2 LEN has dramatically improved the recognition of allergies by doctors of related specialties (Bousquet et al, 2008;Kroegel, 2009;Newson et al, 2014). By contrast, although many dermatologic diseases are considered allergic, few dermatologists treat patients while considering allergen detection and avoidance.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and treatment of allergic diseases in Zhejiang Province: A cross-sectional survey

Wang

Shen

Yang

et al. 2015

J. Zhejiang Univ. Sci. B

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Abstract:Background: The specialty of allergy developed quickly in western countries because of the rapid increase of allergic diseases, whereas it developed relatively slowly in China. The prevalence of allergen sensitization and allergic diseases in Zhejiang Province of China is high and improving the medical services for these diseases is critically needed. Objective: To investigate the working status of the diagnosis and treatment of allergic diseases, including doctor resources, diagnostic methods, and allergen-specific immunotherapy in patients of Zhejiang Province, and to provide instructions for the strategic development of subspecialties of allergic diseases. Methods: First we defined the doctors who treat allergic diseases, and designed a comprehensive questionnaire to collect personal and hospital information for these doctors. The questionnaires were distributed to hospitals with different ranks and from different areas in the province. The general condition of doctor's resources, carryout of diagnostic methods, and allergen-specific immunotherapy were described and variations in the different specialties, hospitals, and areas were further analyzed. Results: Doctors in their thirties with bachelor's degrees were the mainstream for diagnosing and treating allergic diseases. The main specialties of the doctor resources were the specialties of Ear, Nose and Throat (ENT), Respirology, Pediatrics, and Dermatology. The Pediatrics specialty had a more reasonable infrastructure of doctor resources with more young doctors working in this subspecialty. The development of allergy subspecialty varied within hospitals at different levels or from different areas. The carryout of the skin prick test (SPT), serum specific IgE (ssIgE), and subcutaneous immunotherapy (SCIT) was best performed in provincial hospitals, while sublingual immunotherapy (SLIT) was prescribed most commonly in municipal hospitals. The performance of SPT and ssIgE in Hangzhou, Jiaxing, and Wenzhou areas was much better than that in other places. The performance of SCIT and SLIT was best in Wenzhou. Conclusions: Our survey revealed a very initial and unbalanced development for the allergy subspecialty in Zhejiang Province. Doctor resources for allergic diseases were mainly from the specialties of ENT, Respirology, and Pediatrics, and the performance of diagnosis and treatment was mainly focused on provincial and municipal hospitals. Continuous education of allergies could be extended to primary healthcare centers and more efforts should be directed to those areas with poor medical resources.

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Section: Discussionmentioning

confidence: 99%

Diagnosis and treatment of allergic diseases in Zhejiang Province: A cross-sectional survey

Wang

Shen

Yang

et al. 2015

J. Zhejiang Univ. Sci. B

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“…Asthma and allergic rhinitis are linked epidemiologically and pathophysiologically (8,12). The two conditions frequently coexist, and allergic rhinitis has been identified as a risk factor for asthma (8,12). Inflammation of the nasal and bronchial airways is evident in both disorders, and it is hypothesized that they share a common inflammatory process that affects both the upper and lower airways (12).…”

Section: Allergic Rhinitismentioning

confidence: 99%

Section: Allergic Rhinitismentioning

confidence: 99%

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Ebastine in allergic rhinitis and chronic idiopathic urticaria

Sastre

2008

Allergy

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Histamine is a key mediator in the development of allergy symptoms, and oral H1‐antihistamines are among the most widely used treatments for symptomatic relief in conditions such as allergic rhinitis and chronic urticaria. Ebastine is a second‐generation antihistamine which has been shown to be an effective treatment for both seasonal and perennial allergic rhinitis. In controlled clinical trials in adult and adolescent patients with allergic rhinitis, ebastine 10 mg once‐daily improved symptoms to a significantly greater extent than placebo and to a similar extent as loratadine 10 mg and cetirizine 10 mg (both once‐daily), while ebastine 20 mg proved to be more effective than these two comparator antihistamines. In addition, ebastine was significantly more effective than placebo at relieving the symptoms of chronic idiopathic urticaria. Ebastine provides efficacy throughout the 24‐h dosing interval with once‐daily administration and clinical benefit is seen from the first day of treatment. Small studies have found beneficial effects for ebastine in patients with other disorders, including cold urticaria, dermographic urticaria, atopic asthma, mosquito bites and (in combination with pseudoephedrine) the common cold. In addition to the regular ebastine tablet, a fast‐dissolving tablet (FDT) formulation, which disintegrates in the mouth without the aid of a drink, is also available. It has been shown to be bioequivalent to the regular tablet, and to be significantly more effective than desloratadine at reducing histamine‐induced cutaneous wheals. A number of patient surveys demonstrated that the majority of individuals who tried the fast‐dissolving formulation reported it to be convenient for use, fast‐acting and preferred it to their previous antihistamine medication. Perhaps most importantly, a large proportion of patients indicated that they would prefer to use this new formulation in the future. Ebastine has a rapid onset of action and it can be administered once‐daily, with or without food. Dose modifications are not needed in elderly patients, or in those with renal or mild to moderate hepatic impairment. Ebastine is generally well‐tolerated, and clinical studies showed that at usual therapeutic doses of 10 and 20 mg once‐daily, it had no clinically relevant adverse effects on cognitive function and psychomotor performance or on cardiovascular function. In conclusion, ebastine is an effective and generally well‐tolerated treatment for allergic rhinitis and chronic idiopathic urticaria. In addition to the regular tablet formulation, ebastine is available as a FDT, providing a treatment option that is particularly convenient for patients.

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“…В этой связи основной задачей имму-нотерапии можно рассматривать реверсирование актив-ности специфических Т-клеток от Тh2-Тh1 к Тh1-Тh2 [5]. Многолетний опыт проведения СИТ доказал долгосроч-ный эффект данного метода лечения [12,13].…”

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Specific immunotherapy applied in the otorhionolaryngological practice

Gadzhimirzaevа

Gadzhimirzaev

Gamzatova

et al. 2016

Vestn. otorinolaringol.

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В стратегии лечения аллергического ринита (АР) специфическая (аллергенспецифическая) иммунотера-пия (СИТ, АСИТ) приобрела важное значение, ибо ее эф-фективность и безопасность подтверждена с позиций до-казательной медицины [1,2].По мнению экспертов ВОЗ, СИТ является единствен-ным методом, который может принципиально изменить со-стояние чувствительности больного к аллергенам, действуя практически на все фазы аллергической реакции [1,3].Хотя за последние годы отмечается значительный прогресс в фармакотерапии аллергических болезней, сле-дует отметить, что СИТ остается наиболее признанным методом лечения, особенно в детской практике, позволя-ющим достичь устойчивой ремиссии болезни или значи-тельного улучшения в ее течении [4][5][6].Под влиянием СИТ формируется иммунологическая толерантность к антигенной агрессии. При этом рассма-триваются несколько факторов, определяющих эти про-цессы. Наиболее важным из них является образование «блокирующих» антител, принадлежащих к IgG и лишен-ных способности сенсибилизировать ткани, но обладаю-щих аллергенсвязывающей активностью. В пользу данно-го механизма становления иммунологической толерант-ности свидетельствует повышение уровня IgG класса в крови после проведения СИТ [7][8][9]. The objective of the present study was to formulate the indications for the specific immunotherapy (SIT) of ENT diseases based on the results of the examination and treatment of 1058 patients presenting with allergic rhinitis with special reference to the advantages of this approach over pharmacotherapy. Much attention is given to the adverse reactions associated with the appli cation of immunotherapy and the methods for their correction. Personal opinions of the authors with regard to selected aspects of the use of specific immunotherapy in the otorhionolaryngological practice are presented.

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Allergic Rhinitis and its Impact on Asthma (ARIA)

Cited by 443 publications

References 3 publications

Diagnosis and treatment of allergic diseases in Zhejiang Province: A cross-sectional survey

Diagnosis and treatment of allergic diseases in Zhejiang Province: A cross-sectional survey

Ebastine in allergic rhinitis and chronic idiopathic urticaria

Specific immunotherapy applied in the otorhionolaryngological practice

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