Allergic eye disease in children and adolescents seeking eye care in India: Electronic medical records driven big data analytics report II

Das, Anthony Vipin; Donthineni, Pragnya Rao; Prashanthi, Gumpili Sai; Basu, Sayan

doi:10.1016/j.jtos.2019.08.011

Cited by 35 publications

(29 citation statements)

References 21 publications

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“…Allergic conjunctivitis (AC) is an inflammatory disorder of conjunctivae which negatively affects the family and daily activities and is responsible for significant work and school absenteeism [1,2]. e prevalence can vary in intensity, seasonality, gender, country, and region [3][4][5][6]. However, the consensus is that a number of researchers have reported that the incidence of allergic diseases, including various types of allergic conjunctivitis, has increased significantly [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis

Meng

Shi

Zhang

et al. 2020

Journal of Ophthalmology

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Allergic conjunctivitis (AC) is a common allergic disease that is often associated with the onset of rhinitis or asthma. The incidence of AC has increased significantly in recent years possibly due to air pollution and climate warming. AC seriously affects patients’ quality of life and work efficiency. Th (T-helper) 2 immune responses and type I hypersensitivity reactions are generally considered the basis of occurrence of AC. It has been found that new subpopulations of T-helper cells, Th17 cells that produce interleukin-17 (IL-17), play an important role in the Th2-mediated pathogenesis of conjunctivitis. Studies have shown that Th17 cells are involved in a variety of immune inflammation, including psoriasis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, and asthma. However, the role of Th17 and IL-17 in AC is unclear. This paper will focus on how T-helper 17 cells and interleukin-17 are activated in the Th2 immune response of allergic conjunctivitis and how they promote the Th2 immune response of AC.

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Section: Introductionmentioning

confidence: 99%

The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis

Meng

Shi

Zhang

et al. 2020

Journal of Ophthalmology

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“…The indigenously created and customized EMR allowed for a standardized data entry and data collection free of any transcription errors. [9][10][11] The study included multiple centers of our eye care network across a wide geographic reach. This sort of a multitier network analysis allowed for the inclusion of both rural and urban populations, thus covering all the different demographic groups in the study.…”

Section: Discussionmentioning

confidence: 99%

<p>Demography and Clinical Features of Chalazion Among Patients Seen at a Multi-Tier Eye Care Network in India: An Electronic Medical Records Driven Big Data Analysis Report</p>

Das¹,

Dave²

2020

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Purpose: To describe the prevalence, demographics and clinical presentations of chalazion in patients presenting to a multi-tier ophthalmology network in India. Materials and Methods: This was a cross-sectional observational multi-centric hospitalbased study of 1,982,058 new patients presenting between 2010 and 2019. Patients with both symptoms and signs of chalazion were considered as subjects. The data were retrieved using an electronic medical record system. Results: Overall, 11,270 (0.57%) new patients were diagnosed with chalazion. Of these, 1,085 (10%) patients had recurrent chalazia. The prevalence rates were 0.95% in children and 0.51% in adults. Males accounted for 51% of the cases, and 79% had unilateral affliction. The commonest age group affected was the third decade of life (31%). Of the 13,691 affected eyes with chalazion, 39% were located in the upper eyelid, 6% were lateral in position and 3% have multiple swellings at presentation. Conservative treatment was the preferred treatment modality in 85%. Incision and curettage were performed in 15% eyes and intralesional steroid in 0.55% eyes. Of the 15% patients that were advised surgery, 9% underwent the procedure with a conversion rate of 58%. Conclusion: Only a miniscule percentage of patients seeking eye care in India are affected by chalazion. It is slightly more common in males and is usually unilateral and largely affects the upper eyelids. It is recurrent in a tenth of the cases. Conservative management is the preferred modality.

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“…Of the 1,458,830 new patients recruited 21,290 (1.46%) had recent-onset DED with age, gender, residence, occupation, socio-economic status having a significant impact in development of the disease [19], while of the 259,969 new patients (≤21 years) 10.1% had AED. Boys with atopy during mid childhood and from middle to higher income families were commonly affected by AED which was self-limiting by adolescence [20].…”

Section: Discussionmentioning

confidence: 99%

Ophthatome™: an integrated knowledgebase of ophthalmic diseases for translating vision research into the clinic

et al. 2020

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Background Medical big data analytics has revolutionized the human healthcare system by introducing processes that facilitate rationale clinical decision making, predictive or prognostic modelling of the disease progression and management, disease surveillance, overall impact on public health and research. Although, the electronic medical records (EMR) system is the digital storehouse of rich medical data of a large patient cohort collected over many years, the data lack sufficient structure to be of clinical value for applying deep learning methods and advanced analytics to improve disease management at an individual patient level or for the discipline in general. Ophthatome™ captures data contained in retrospective electronic medical records between September 2012 and January 2018 to facilitate translational vision research through a knowledgebase of ophthalmic diseases. Methods The electronic medical records data from Narayana Nethralaya ophthalmic hospital recorded in the MS-SQL database was mapped and programmatically transferred to MySQL. The captured data was manually curated to preserve data integrity and accuracy. The data was stored in MySQL database management system for ease of visualization, advanced search functions and other knowledgebase applications. Results Ophthatome™ is a comprehensive and accurate knowledgebase of ophthalmic diseases containing curated clinical, treatment and imaging data of 581,466 ophthalmic subjects from the Indian population, recorded between September 2012 and January 2018. Ophthatome™ provides filters and Boolean searches with operators and modifiers that allow selection of specific cohorts covering 524 distinct ophthalmic disease types and 1800 disease sub-types across 35 different anatomical regions of the eye. The availability of longitudinal data for about 300,000 subjects provides additional opportunity to perform clinical research on disease progression and management including drug responses and management outcomes. The knowledgebase captures ophthalmic diseases in a genetically diverse population providing opportunity to study genetic and environmental factors contributing to or influencing ophthalmic diseases. Conclusion Ophthatome™ will accelerate clinical, genomic, pharmacogenomic and advanced translational research in ophthalmology and vision sciences.

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Allergic eye disease in children and adolescents seeking eye care in India: Electronic medical records driven big data analytics report II

Cited by 35 publications

References 21 publications

The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis

The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis

<p>Demography and Clinical Features of Chalazion Among Patients Seen at a Multi-Tier Eye Care Network in India: An Electronic Medical Records Driven Big Data Analysis Report</p>

Ophthatome™: an integrated knowledgebase of ophthalmic diseases for translating vision research into the clinic

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