Allergic contact dermatitis to panthenol and cocamidopropyl PG dimonium chloride phosphate in a facial hydrating lotion

Abstract

Dexpanthenol is the alcohol corresponding to pantothenic acid (the water-soluble vitamin B(5)). Although it is a common ingredient in many pharmaceuticals and cosmetics, contact allergy is relatively uncommon. Cocamidopropyl PG dimonium chloride phosphate is a phospholipid complex derived from pure coconut oil, and contact allergy is rare. We report a case of allergic contact dermatitis to panthenol and cocamidopropyl PG dimonium chloride phosphate in a facial hydrating lotion.

Allergic contact dermatitis caused by panthenol: a rare but relevant sensitizer

“…It is a common ingredient in pharmaceutical products, for example in topical treatments for rhinitis, conjunctivitis, sunburn, and wounds, mainly because of its anti‐inflammatory and wound‐healing properties. Moreover, it is used in cosmetics, such as hair lotions, sunscreens, nail polish, and make‐up, for its moisturizing and conditioning properties .…”

Allergic contact dermatitis caused by panthenyl ethyl ether in a patient with psoriasis

“…To our knowledge, panthenyl ethyl ether has been reported as sensitising only once, in 1984 by van Ketel . Panthenyl ethyl ether is made from the alcoholic compound panthenol, which has been rarely reported as sensitizing . Nevertheless, our patient showed a negative result when tested with this latter compound.…”

Contact sensitization in patients with suspected cosmetic intolerance: results of the IVDK 2006–2011

“…cetyl alcohol, phenoxyethanol and panthenol. The latter has been described before as contact allergen in cosmetics . Phenoxyethanol is extremely widely used as preservative in cosmetics, and it is an extremely rare sensitizer .…”