Allergic contact dermatitis caused by panthenyl ethyl ether in a patient with psoriasis

Foti, Caterina; Romita, Paolo; Bufano, Tamara; Antelmi, Annarita

doi:10.1111/cod.12667

Cited by 5 publications

(3 citation statements)

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“…In addition, two reports of contact dermatitis to a related compound, panthenyl ethyl ether (CAS no. 667‐83‐4), following use of a hair lotion and an emollient stick, respectively, have also been published 11,12 . Of interest, in one of them panthenol was patch tested with negative results as in our case, showing that cross‐reactions among these related compounds do not necessarily occur.…”

Section: Discussionmentioning

confidence: 57%

Calcium pantothenate is present in cosmetics and may cause allergic contact dermatitis

et al. 2020

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Calcium pantothenate (CAS no. 137‐08‐6) is the calcium salt of pantothenic acid (vitamin B5). It is used in cosmetics due to its anti‐static and hair conditioning properties. A 53‐year‐old female nurse's aide presented with intermittent facial eruptions (Figure S1). Patch tests were positive to calcium pantothenate, an ingredient of two of her products (a cleansing milk and a facial tonic). To our knowledge, no previous cases of sensitization from calcium pantothenate have been reported except for one case of systemic dermatitis from a nutritional supplement in a dexpanthenol‐sensitized patient.

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Section: Discussionmentioning

confidence: 57%

Calcium pantothenate is present in cosmetics and may cause allergic contact dermatitis

et al. 2020

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“…To date, there is no standardization regarding the best concentrations and vehicles for patch testing dexpanthenol, 46 , 47 considered a strong sensitizer that does not cross‐react with d ‐panthenyl ethyl ether. 46 , 47 , 48 …”

Section: Reviewmentioning

confidence: 99%

“…45 To date, there is no standardization regarding the best concentrations and vehicles for patch testing dexpanthenol, 46,47 considered a strong sensitizer that does not cross-react with D-panthenyl ethyl ether. [46][47][48] Vitamin B5 in cosmetics as calcium pantothenate was reported to be a relevant sensitizer. 49 However, due to the complexity of vitamin B5 metabolic pathways, it is also possible that pantothenate may require metabolic activation.…”

Section: Vitamin B5mentioning

confidence: 99%

Allergic contact dermatitis from vitamins: A systematic review

Foti

Calogiuri

Nettis

et al. 2022

Health Science Reports

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Background and Aims Vitamins are bioactive compounds naturally found in many different types of food and required by the human body for many biological functions and enzymatic activities. Due to their antioxidant properties, certain vitamin derivatives have been synthesized for inclusion in many cosmetics, thus leading to an increasing incidence of allergic contact dermatitis (ACD) cases. Therefore, the present review may be helpful to provide an insight into the sensitizing role of at least certain vitamins and may also offer possible patch test alternatives for definitive diagnosis. Methods This study was conducted in accordance with the Preferred Reporting Items for Systematic reviews and Meta‐Analyses (PRISMA) guidelines. Literature search regarding ACD cases to vitamins was performed using the Medline, PubMed, Scopus, EMBASE, and Google Scholar databases from January 1940 up to June 2021. Results A total of 4494 articles matched the keywords used for the researched. Records removed before screening included 15 duplicate articles and 3429 not eligible articles (e.g., not written in English, studies on animals, not relevant to the topic). A total of 1050 articles underwent the screening phase and 258 were therefore excluded as they were not primary studies. Subsequentially, 792 articles were considered eligible for the review and 688 of them were finally excluded as they did not report the outcome of interest. Therefore, 104 articles were definitely included in the present review. Conclusion ACD to vitamins is still probably an underestimated issue in cosmetology, as many vitamins are considered “natural” and therefore “safe” ingredients. On the contrary, according to current literature, almost all vitamins contained in topical products are able to induce allergic reactions, with the exception of vitamin B2 and vitamin B9. Patch tests are not standardized, thus leading to difficulties in diagnosis.

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Allergic contact dermatitis caused by panthenyl ethyl ether in a patient with psoriasis

Cited by 5 publications

References 6 publications

Calcium pantothenate is present in cosmetics and may cause allergic contact dermatitis

Calcium pantothenate is present in cosmetics and may cause allergic contact dermatitis

Allergic contact dermatitis from vitamins: A systematic review

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