Allergic contact dermatitis caused by panthenol: a rare but relevant sensitizer

Clerens, Ilse; Goossens, An

doi:10.1111/cod.12685

Cited by 21 publications

(15 citation statements)

References 12 publications

(16 reference statements)

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“…Although ACD caused by dexpanthenol is considered to be rare, with the frequency in previously reported series ranging from 0.2% to 0.7%, we found 1.16% positive reactions when it was tested in the cosmetic/vehicle series, and a slightly higher proportion of 1.23% in the last 3 years when it was tested in consecutive patients; this was a non‐significant difference between the 2 types of testing. This suggested to us that almost all patients sensitized to this hapten are detected with aimed patch testing, that is, if the allergen is included in a cosmetic series and a series of vehicles for topical drugs.…”

Section: Discussionsupporting

confidence: 73%

“…Two cases of ACD caused by dexpanthenol were reported in children, 1,3 but all age groups seem to be affected, as in our study, with the age of cases ranging from 15 to 75 years. There is also Although ACD caused by dexpanthenol is considered to be rare, with the frequency in previously reported series ranging from 0.2% to 0.7%, 11 we found 1.16% positive reactions when it was tested in the cosmetic/vehicle series, and a slightly higher proportion of 1.23% in the last 3 years when it was tested in consecutive patients;…”

Section: Discussionmentioning

confidence: 62%

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Allergic contact dermatitis caused by dexpanthenol—Probably a frequent allergen

et al. 2018

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 62%

Allergic contact dermatitis caused by dexpanthenol—Probably a frequent allergen

et al. 2018

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“…Vitamin and derivatives have also been reported as sensitizers, i.e., panthenol, a vitamin B5 derivative that has anti-inflammatory, woundhealing, and hydrating properties, is a rare but relevant allergen in both topical pharmaceuticals and cosmetics [109], often present in wet wipes [110], and vitamin K 1 oxide (phytomenadione epoxide) has been reported even as the cause of an erythema multiforme-like reaction [25]. Finally, other rare causes of ADC have been described as well, i.e., triethanolamine [111], methoxy PEG-22/dodecyl glycol copolymer [112], and VEA Lipogel [113].…”

Section: Other Cosmetic Allergensmentioning

confidence: 99%

Contact Allergy in Children

Goossens

Morren

2020

Contact Dermatitis

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Contact allergy in children is more frequent than previously suspected. Metals, ingredients of pharmaceutical and cosmetic products, preservatives/biocides, para-phenylenediamine, rubber additives, plastics and resins, and plants are known sensitizers in them. In adolescents, occupation-induced allergens may be involved as well. Sometimes unusual clinical presentations of allergic contact dermatitis can be observed. If there is a suspicion by history and clinical picture, or there is an unexplained eczema at particular body sites, patch testing should be performed at all ages. Patch testing in children is safe, but false-positive (as false-negative) reactions are, of course, possible. Patch test reactions must be interpreted carefully, particularly in atopic subjects, since their skin is readily irritated; this is especially the case for metals. An abbreviated baseline series, supplemented with relevant allergens from other test series, as well as contacted products and respective ingredients suggested by the history, should be patch tested.

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“…Allergic contact dermatitis caused by dexpanthenol is rare, with a share of 0.2% to 0.7% positive reactions in published series . However, it is considered to be a relevant allergen, and is present as an ingredient in a varied and growing number of products .…”

Section: Discussionmentioning

confidence: 99%

Allergic contact dermatitis caused dexpanthenol—But is that all?

et al. 2019

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Dexpanthenol is an analogue of pantothenic acid (vitamin B 5 ) that is used in pharmaceuticals and cosmetics. 1 Pantothenic acid is essential for the synthesis of coenzyme A in cells involving in the Krebs cycle. CASE REPORTA 49-year-old Caucasian man presented with generalized eczema of the trunk and limbs that had lasted for~10 days. Eight weeks before, he had sustained a few scratches on the right leg caused by plants during occupational gardening. He reported having applied a dexpanthenol-containing cream, and, a few days later, he developed local erythema and vesicles, with subsequent spreading.Allergic contact dermatitis caused by the topical drug was considered. Use of the cream was stopped, and the patient was treated with oral prednisolone. After rapid improvement, topical methylprednisolone aceponate cream was prescribed to achieve complete remission. However, the patient mentioned worsening of the residual dermatitis after applying the latter cream, and stopped using it. Physical examination showed an itchy erythematous desquamative plaque on the right leg (Supporting Information Figure S1).Patch testing with IQ Ultra chambers was performed with the Portuguese Contact Dermatitis Research Group baseline series, a cosmetics and excipients series (Chemotechnique Diagnostics, Vellinge, Sweden), and the dexpanthenol-containing cream used, tested "as is." Readings were performed on day 3 according to European Society of Contact Dermatitis guidelines, and showed positive reactions to cetearyl alcohol 20% pet., dexpanthenol 5% pet., and the dexpanthenol-containing cream. Both ingredients were present in the dexpanthenol-containing cream, and cetearyl alcohol was also present in the methylprednisolone aceponate cream (Figure 1).

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Allergic contact dermatitis caused by panthenol: a rare but relevant sensitizer

Cited by 21 publications

References 12 publications

Allergic contact dermatitis caused by dexpanthenol—Probably a frequent allergen

Allergic contact dermatitis caused by dexpanthenol—Probably a frequent allergen

Contact Allergy in Children

Allergic contact dermatitis caused dexpanthenol—But is that all?

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