Allergic contact dermatitis from black cumin (<i>Nigella sativa</i>) oil after topical use

Steinmann, Alexander; Schätzle, M.; Agathos, Monika; Breit, Reinhard

doi:10.1111/j.1600-0536.1997.tb00219.x

Cited by 40 publications

(22 citation statements)

References 4 publications

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“…Patients using Nigella ointment reported no serious side‐effect that made this drug a potential substitute for corticosteroids although there is no data on long‐term effect of this medication on skin. Notwithstanding our results, there were two case reports of allergic contact dermatitis after applying topical Nigella oil 9,10 . We did not use Nigella ointment on normal skin but in our participants, there was no deterioration in the eczematous lesion or allergic reactions in the skin around them (Figs 4 and 5).…”

Section: Discussionmentioning

confidence: 49%

Comparison of therapeutic effect of topical Nigella with Betamethasone and Eucerin in hand eczema

Yousefi

Barikbin

Kamalinejad

et al. 2012

Acad Dermatol Venereol

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Section: Discussionmentioning

confidence: 49%

Comparison of therapeutic effect of topical Nigella with Betamethasone and Eucerin in hand eczema

Yousefi

Barikbin

Kamalinejad

et al. 2012

Acad Dermatol Venereol

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“…Although these findings suggest that Nigella sativa can potentially trigger Th2 immune responses, there is no clear evidence that the Th2 cell population is increased when splenocytes are treated with the aqueous extract of Nigella sativa. Interestingly, two studies have suggested that Nigella sativa oil may be associated with cases of contact dermatitis (Steinmann et al, 1997;Zedlitz et al, 2002). On the other hand, Nigella sativa and its active ingredients have been shown to inhibit the release of histamine from sensitized mast cells after antigen exposure (Chakravarty, 1993) and to inhibit the synthesis of thromboxane and leukotrienes in peritoneal leukocytes (Houghton et al, 1995).…”

Section: Discussionmentioning

confidence: 98%

Nigella sativa modulates splenocyte proliferation, Th1/Th2 cytokine profile, macrophage function and NK anti-tumor activity

Majdalawieh

Hmaidan

Carr

2010

Journal of Ethnopharmacology

149

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“…Previously, cases of contact dermatitis have been reported with the use of essential oils present in cosmetics and perfumes. These cases were treatable with topical corticosteroids (Steinmann et al, 1997;Zedlitz et al, 2002).…”

Section: Toxicological Propertiesmentioning

confidence: 99%

Pharmacological and toxicological properties of Nigella sativa

Ali

Blunden

2003

Phytotherapy Research

1,015

747

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The seeds of Nigella sativa Linn. (Ranunculaceae), commonly known as black seed or black cumin, are used in folk (herbal) medicine all over the world for the treatment and prevention of a number of diseases and conditions that include asthma, diarrhoea and dyslipidaemia. This article reviews the main reports of the pharmacological and toxicological properties of N. sativa and its constituents. The seeds contain both fixed and essential oils, proteins, alkaloids and saponin. Much of the biological activity of the seeds has been shown to be due to thymoquinone, the major component of the essential oil, but which is also present in the fi ed oil. The pharmacological actions of the crude extracts of the seeds (and some of its active constituents, e.g. volatile oil and thymoquinone) that have been reported include protection against nephrotoxicity and hepatotoxicity induced by either disease or chemicals. The seeds/oil have antiinflammatory, analgesic, antipyretic, antimicrobial and antineoplastic activity. The oil decreases blood pressure and increases respiration. Treatment of rats with the seed extract for up to 12 weeks has been reported to induce changes in the haemogram that include an increase in both the packed cell volume (PCV) and haemoglobin (Hb), and a decrease in plasma concentrations of cholesterol, triglycerides and glucose. The seeds are characterized by a very low degree of toxicity. Two cases of contact dermatitis in two individuals have been reported following topical use. Administration of either the seed extract or its oil has been shown not to induce significant adverse effects on liver or kidney functions. It would appear that the beneficial effects of the use of the seeds and thymoquinone might be related to their cytoprotective and antioxidant actions, and to their effect on some mediators of inflammation.

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Allergic contact dermatitis from black cumin (Nigella sativa) oil after topical use

Cited by 40 publications

References 4 publications

Comparison of therapeutic effect of topical Nigella with Betamethasone and Eucerin in hand eczema

Comparison of therapeutic effect of topical Nigella with Betamethasone and Eucerin in hand eczema

Nigella sativa modulates splenocyte proliferation, Th1/Th2 cytokine profile, macrophage function and NK anti-tumor activity

Pharmacological and toxicological properties of Nigella sativa

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