Allergens of permanent hair dyes induces epidermal damage, skin barrier loss and IL-1 α increase in epidermal in vitro model

Zanoni, Thalita B.; Pedrosa, Tatiana do Nascimento; Catarino, Carolina Motter; Spiekstra, Sander W.; Oliveira, Danielle Palma de; Hartog, G.J.M. den; Bast, Aalt; Hagemann, Geja; Gibbs, Susan; Barros, Sílvia Berlanga de Moraes; Maria‐Engler, Silvya Stuchi

doi:10.1016/j.fct.2017.12.033

Cited by 15 publications

(9 citation statements)

References 56 publications

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“…Because of such widespread use, hair dye industries are now among the most profitable in the cosmetics sector . As a matter of fact, studies suggest that over 50% of the population in developed countries has dyed their hair at least once in their life. ,− Despite several studies reporting the potential carcinogenicity of certain conventional hair dye components, frequent development of allergies in clients and colorists, and dye-induced hair damage, the use of small molecule-based dyes in modern society continues to expand, and the industry has made only few minor advances in its chemistry. ,,− …”

Section: Introductionmentioning

confidence: 99%

Mimicking Natural Human Hair Pigmentation with Synthetic Melanin

et al. 2020

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Human hair is naturally colored by melanin pigments, which afford myriad colors from black, to brown, to red depending on the chemical structures and specific blends. In recent decades, synthetic efforts have centered on dopamine oxidation to polydopamine, an effective eumelanin similar to the one found in humans. To date, only a few attempts at polydopamine deposition on human hair have been reported, and their translation to widespread usage and potential commercialization is still hampered by the harsh conditions employed. We reasoned that novel, mild, biocompatible approaches could be developed to establish a metal-free route to tunable, nature-inspired, long-lasting coloration of human hair. Herein, we describe synthetic and formulation routes to achieving this goal and show efficacy on a variety of human hair samples via multiple spectroscopic and imaging techniques. Owing to the mild and inexpensive conditions employed, this novel approach has the potential to replace classical harsh hair dyeing conditions that have raised concerns for several decades due to their potential toxicity.

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Section: Introductionmentioning

confidence: 99%

Mimicking Natural Human Hair Pigmentation with Synthetic Melanin

et al. 2020

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“…Although the hair dye industry is thriving, the biosafety of organic molecule dyes is always problematic. 53 Organic molecules with molecular weights of less than 500 Da can easily pass the skin barrier. 54 However, the molecular weight of most organic hair dyes, such as pphenylenediamine, is less than 500 Da, and they are reported to cause allergies and skin cancer.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Although the hair dye industry is thriving, the biosafety of organic molecule dyes is always problematic . Organic molecules with molecular weights of less than 500 Da can easily pass the skin barrier .…”

Section: Resultsmentioning

confidence: 99%

“Gold Inlaid with Hair”: Permanent Fluorescent Hair Dyeing Using Fast Protein-Assisted Biomineralization of Gold Nanoclusters

Shu

Sun

Zhou

et al. 2021

ACS Sustainable Chem. Eng.

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Permanent fluorescent hair dyeing is one of the modern coloration modes to meet the increasing demands of personality and fashion statements. However, the limited durability and narrow Stokes shift of small molecule dyes hinder the permanent performance and distinguished use of fluorescent hair dyes from conventional hair coloration. Here, fluorescent metal nanomaterials, gold nanoclusters, have been utilized as hair dyes and embedded inside hair through a fast protein-assisted biomineralization approach under heating and alkaline conditions. Heat and alkalinity not only ensure that the scales of hair fully open and the dye precursor is deeply pervasive but also largely promote the reducibility of hair protein. The introduction of gold nanocluster bestows a broad range of new photophysical, much enhanced antistatic, mechanical, durable, and biocompatible properties to hair, largely improving the comfort experience and cosmetic performance.

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“…Fibrinopeptide B is a known potent chemoattractant, and its preferential release suggests a physiological purpose in cellular response to injury 26 . Tissue damage induced by permanent hair dyes has been reported 27 , suggesting that the observed fibrinopeptide B association may reflect such inflammatory responses.…”

Section: Discussionmentioning

confidence: 97%

Serum metabolomic profile of hair dye use

Lim

Huang

Weinstein

et al. 2023

Sci Rep

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The International Agency for Research on Cancer reported that some chemicals in hair dyes are probably carcinogenic to those exposed to them occupationally. Biological mechanisms through which hair dye use may be related to human metabolism and cancer risk are not well-established. We conducted the first serum metabolomic examination comparing hair dye users and nonusers in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Metabolite assays were conducted using ultrahigh performance liquid chromatography-tandem mass spectrometry. The association between metabolite levels and hair dye use was estimated using linear regression, adjusting for age, body mass index, smoking, and multiple comparisons. Among the 1,401 detected metabolites, 11 compounds differed significantly between the two groups, including four amino acids and three xenobiotics. Redox-related glutathione metabolism was heavily represented, with L-cysteinylglycine disulfide showing the strongest association with hair dye (effect size (β) = − 0.263; FDR adjusted p-value = 0.0311), along with cysteineglutathione disulfide (β = − 0.685; FDR adjusted p-value = 0.0312). 5alpha-Androstan-3alpha,17beta-diol disulfate was reduced in hair dye users (β = − 0.492; FDR adjusted p-value = 0.077). Several compounds related to antioxidation/ROS and other pathways differed significantly between hair dye users and nonusers, including metabolites previously associated with prostate cancer. Our findings suggest possible biological mechanisms through which the use of hair dye could be associated with human metabolism and cancer risk.

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Allergens of permanent hair dyes induces epidermal damage, skin barrier loss and IL-1 α increase in epidermal in vitro model

Cited by 15 publications

References 56 publications

Mimicking Natural Human Hair Pigmentation with Synthetic Melanin

Mimicking Natural Human Hair Pigmentation with Synthetic Melanin

“Gold Inlaid with Hair”: Permanent Fluorescent Hair Dyeing Using Fast Protein-Assisted Biomineralization of Gold Nanoclusters

Serum metabolomic profile of hair dye use

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