Serum metabolomic profile of hair dye use

Abstract

The International Agency for Research on Cancer reported that some chemicals in hair dyes are probably carcinogenic to those exposed to them occupationally. Biological mechanisms through which hair dye use may be related to human metabolism and cancer risk are not well-established. We conducted the first serum metabolomic examination comparing hair dye users and nonusers in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Metabolite assays were conducted using ultrahigh performance liquid chromatography-tandem mass spectrometry. The association between metabolite levels and hair dye use was estimated using linear regression, adjusting for age, body mass index, smoking, and multiple comparisons. Among the 1,401 detected metabolites, 11 compounds differed significantly between the two groups, including four amino acids and three xenobiotics. Redox-related glutathione metabolism was heavily represented, with L-cysteinylglycine disulfide showing the strongest association with hair dye (effect size (β) = − 0.263; FDR adjusted p-value = 0.0311), along with cysteineglutathione disulfide (β = − 0.685; FDR adjusted p-value = 0.0312). 5alpha-Androstan-3alpha,17beta-diol disulfate was reduced in hair dye users (β = − 0.492; FDR adjusted p-value = 0.077). Several compounds related to antioxidation/ROS and other pathways differed significantly between hair dye users and nonusers, including metabolites previously associated with prostate cancer. Our findings suggest possible biological mechanisms through which the use of hair dye could be associated with human metabolism and cancer risk.

Associations between use of chemical hair products and epigenetic age: Findings from the Sister Study

“…Although the use of chemical hair products, particularly permanent dye and straighteners/relaxers, has been linked to the incidence of cancers and other adverse health outcomes, 5–13 our findings suggest that these relationships may not be primarily attributed to biological aging pathways captured by DunedinPACE, GrimAgeAccel, or PhenoAgeAccel. Alternative biological pathways may be worth investigating, 36 particularly in racially diverse populations, to better understand the impact of chemical hair products.…”

“…DunedinPACE, GrimAgeAccel, or PhenoAgeAccel. Alternative biological pathways may be worth investigating, 36 particularly in racially diverse populations, to better understand the impact of chemical hair products.…”

Designing Multifunctional MXene Nanosheets Hair Dye

“…As the worldwide aging population increases and the demand for hair dyes to improve appearance increases, research into safe and effective hair dyes is expanding 31,32,33,34,35 . This study explored the potential of MXene nanosheet-based hair dyes for safe and multifunctional hair dyeing.…”

NMR analysis of structural geometry and molecular dynamics in perovskite-type N(CH3)4CdBr3 crystal near high-temperature phase transition

“…Further, the powder X-ray diffraction (PXRD) patterns were obtained at 300 K and 410 K using an XRD spectrometer with a Mo Kα radiation source by utilizing the SCXRD method. 32…”

“…Further, the powder X-ray diffraction (PXRD) patterns were obtained at 300 K and 410 K using an XRD spectrometer with a Mo Ka radiation source by utilizing the SCXRD method. 32 NMR spectra of the N(CH 3 ) 4 CdBr 3 crystals were recorded using a solid-state NMR spectrometer (Bruker 400 MHz Avance II+) at KBSI. The 1 H magic angle spinning (MAS) NMR data at the Larmor frequency of u o /2p = 400.13 MHz and the 13 C MAS NMR data at the Larmor frequency of u o /2p = 100.61 MHz were measured as a function of temperature.…”