All-trans retinoic acid prevents epidural fibrosis through NF-κB signaling pathway in post-laminectomy rats

To what extent topical application of cova™ and tisseel® cause spinal peridural fibrosis? comparison with adcon® gel: an experimental study in rat model.

“…Formation of PF also involves the transformation of fibroblasts to myofibroblasts. Transforming Growth Factor-1β (TGF-1β) plays an important role in transformation of fibroblasts into myofibroblasts (20,21,34).…”

“…Peridural fibrosis may be a risk of the usage of these topical agents. In this study, we aimed to compare the effects of Cova The multi-factorial process that causes PF involves increased extracellular matrix components such as fibronectin, dermatan sulfate and collagen fibers and the accumulation of fibroblasts with cellular reduction (20,21,28,34). FBSS generally leads to revision surgeries with higher rates of complications mostly due to the disrupted anatomical plane.…”

An efficient system for selection and culture of Schwann cells from adult rat peripheral nerves

“…It has been previously shown that the survival rate of skin derived FBs is reduced with treatment of all trans retinoic acid (ATRA; Daly and Weston 1986). Recently, RA has been used to prevent epidural fibrosis after laminectomy (Zhang et al 2013). Our preliminary results exhibited dramatic reduction in survival rate of the epineural FBs with even low concentrations of ATRA in comparison with untreated cells (Supporting data).…”

Effect of etanercept on the formation of epidural fibrosis in an experimental model

“…In these studies, autologous fat grafts, Silastic, gelfoam, recombinant plasminogen activator, polyvinyl alcohol hydrogel membrane and carbohydrate polymers were used (8,11,(16)(17)(18). Despite these agents, an effective treatment was not developed (35).…”

“…Exaggerated tissue fibrosis may lead to the recurrence of complaints in the postoperative period by causing excessive adhesion in the dura mater and nerve roots. This clinical condition is called failed back surgery syndrome (FBSS) (20,34,35). FBSS was reported to develop in 8-40% of patients who undergo lumbar laminectomy (3).…”