To what extent topical application of cova&amp;#8482; and tisseel® cause spinal peridural fibrosis? comparison with adcon® gel: an experimental study in rat model.

Kazanci, Atilla; Gurcan, Oktay; Gürçay, Ahmet Gürhan; Önder, Evrim; Kazanci, Burak; Yaman, Mesut Emre; Bavbek, Murad

doi:10.5137/1019-5149.jtn.16809-15.1

Cited by 4 publications

(5 citation statements)

References 26 publications

(43 reference statements)

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“…Li et al described a significantly lower epineurium collagen thickness after the use of chitosan combined with hyaluronic acid after neural crush injury [16]. Kazanci et al described FG to minimize the development of spinal peridural fibrosis after laminectomy in a preclinical study [29]. Our qualitative and quantitative findings further support the hypothesis of achieving preventive effects on postoperative perineural scarring by the application of sealant materials around peripheral nerves and demonstrate that FG is a viable candidate for this technique.…”

Section: Discussionsupporting

confidence: 71%

“…It has been investigated for different indications, including the replacement of epineural sutures [25], the improvement of the tensile strength of epineural sutures [26], or as a conduit for the bridging of nerve defects where no direct repair is possible after peripheral nerve injury [27]. Its application has been described in both peripheral and central neurosurgery [28] and was demonstrated to prevent peridural fibrosis following laminectomy [29]. The mechanisms of action of FG and its potential to prevent adhesion or scar tissue formation are the subject of ongoing research.…”

Section: Introductionmentioning

confidence: 99%

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Fibrin Glue Coating Limits Scar Tissue Formation around Peripheral Nerves

Mayrhofer-Schmid,

Aman,

Panayi

et al. 2024

IJMS

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Scar tissue formation presents a significant barrier to peripheral nerve recovery in clinical practice. While different experimental methods have been described, there is no clinically available gold standard for its prevention. This study aims to determine the potential of fibrin glue (FG) to limit scarring around peripheral nerves. Thirty rats were divided into three groups: glutaraldehyde-induced sciatic nerve injury treated with FG (GA + FG), sciatic nerve injury with no treatment (GA), and no sciatic nerve injury (Sham). Neural regeneration was assessed with weekly measurements of the visual static sciatic index as a parameter for sciatic nerve function across a 12-week period. After 12 weeks, qualitative and quantitative histological analysis of scar tissue formation was performed. Furthermore, histomorphometric analysis and wet muscle weight analysis were performed after the postoperative observation period. The GA + FG group showed a faster functional recovery (6 versus 9 weeks) compared to the GA group. The FG-treated group showed significantly lower perineural scar tissue formation and significantly higher fiber density, myelin thickness, axon thickness, and myelinated fiber thickness than the GA group. A significantly higher wet muscle weight ratio of the tibialis anterior muscle was found in the GA + FG group compared to the GA group. Our results suggest that applying FG to injured nerves is a promising scar tissue prevention strategy associated with improved regeneration both at the microscopic and at the functional level. Our results can serve as a platform for innovation in the field of perineural regeneration with immense clinical potential.

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Section: Discussionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Fibrin Glue Coating Limits Scar Tissue Formation around Peripheral Nerves

Mayrhofer-Schmid,

Aman,

Panayi

et al. 2024

IJMS

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“…Regarding the new capillary volume, it is found as 0.7800.131 µm 3 in Sham and 1.8970.09 µm 3 in Surgery+Thymoquinone groups, respectively. There is statistically significant difference between the groups (p=0.01) ( Figure 3, A, B).…”

Section: Resultsmentioning

confidence: 93%

“…The failed back syndrome is identified as the persistent pain in lower back, leg, hip, and thigh in the patients who went through the surgical procedure of laminectomy. It is also named "post-laminectomy syndrome" (PLS) [3]. inappropriate application of the surgical procedure, the disruption of the internal disc, spinal stenosis and peridural fibrosis are among the possible causes of the failed back syndrome [4,6].…”

Section: Introductionmentioning

confidence: 99%

Stereological and histopathological evaluation of the effect of Thymoquinone on peridural fibrosis following laminectomy in rats

Turkoz¹,

Türköz²,

Önger³

et al. 2021

Turk J Med Sci

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The stereological and histopathological evaluation of the effect of Thymoquinone on peridural fibrosis following laminectomy in rats Abstract Background/aim: This study was aimed to investigate the effects of thymoquinone, which is the essential bioactive component of the volatile oil of Nigella sativa on the peridural fibrosis in rats following laminectomy. Materials and methods: Twenty female Wistar Albino rats were used in our study. The rats were randomly divided into two groups as Sham and Surgery+Thymoquinone. Both groups underwent laminectomy at L1, under general anesthesia. The sham group was not subjected to any drug application. The second group was treated with intraperitoneal 10 mg/kg thymoquinone per day for a period of 28 days, following the same surgical procedure. All the groups were sacrificed after four weeks and the laminectomy area was examined in terms of new bone volume, capillary volume and fibrosis volume using stereological approaches. Results: Statistically significant differences were found between the Sham and Surgery+Thymoquinone groups, in terms of the new bone volume (p=0.01), capillary volume (p=0.01) and fibrosis volume (p<0.001). It was noted that thymoquinone caused significant increase in the new bone volume and vascular volume and a significant decrease in the fibrosis volume. Conclusion: The results of our study indicate that thymoquinone is effective in decreasing the peridural fibrosis when applied on laminectomy model.

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“…The basis for this gel is gelatin, largely composed of collagen, combined with a polyglycan ester in PBS [30]. While the control gel did not show scar preventive effects, ADCON gel has been demonstrated to have preventive effects on adhesion formation in tendon injuries and spinal peridural fibrosis additionally to peripheral nerves [15,30,61]. However, case reports of patients experiencing cerebrospinal fluid leaks after the use of the ADCON gel led to the suspension of its use in spinal surgery [62].…”

Section: Discussionmentioning

confidence: 99%

Shielding the Nerve: A Systematic Review of Nerve Wrapping to Prevent Adhesions in the Rat Sciatic Nerve Model

Mayrhofer-Schmid,

Klemm,

Aman

et al. 2023

JPM

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Background: Peripheral nerve pathology is frequently encountered in clinical practice among peripheral nerve and extremity surgeons. One major factor limiting nerve regeneration and possibly leading to revision surgeries is the development of traumatic or postoperative adhesions and scarring around nerves. In experimental models, different materials have been studied to limit scar tissue formation when wrapped around nerves. Methods: A systematic review of studies describing nerve-wrapping materials in a non-transectional rat sciatic nerve model was performed following the PRISMA guidelines. Literature describing nerve-wrapping methods for the prevention of peripheral nerve scarring in rat sciatic nerve models was identified using PubMed and Web of Science, scanned for relevance and analyzed. Results: A total of 15 original articles describing 23 different materials or material combinations for nerve wrapping were included. The heterogeneity of the methods used did not allow a meta-analysis, thus, a systematic review was performed. Out of 28 intervention groups, 21 demonstrated a preventive effect on scar tissue formation in at least one qualitative or quantitative assessment method. Conclusions: The analyzed literature describes a variety of materials from different origins to limit peripheral nerve scarring and adhesions. Thus, a scar-preventive effect by wrapping peripheral nerves as adhesion prophylaxis seems likely. However, a quantitative comparison of the studies to identify the optimal material or technique is not possible with the diversity of used models and study designs. Therefore, further research needs to be performed to identify the optimal nerve wraps to be used routinely in clinical practice.

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To what extent topical application of cova™ and tisseel® cause spinal peridural fibrosis? comparison with adcon® gel: an experimental study in rat model.

Cited by 4 publications

References 26 publications

Fibrin Glue Coating Limits Scar Tissue Formation around Peripheral Nerves

Fibrin Glue Coating Limits Scar Tissue Formation around Peripheral Nerves

Stereological and histopathological evaluation of the effect of Thymoquinone on peridural fibrosis following laminectomy in rats

Shielding the Nerve: A Systematic Review of Nerve Wrapping to Prevent Adhesions in the Rat Sciatic Nerve Model

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