All-Optical Nanoscale pH Meter

Bishnoi, Sandra Whaley; Rozell, Christopher J.; Levin, Carly S.; Gheith, Muhammed K.; Johnson, Bruce R.; Johnson, Don H.; Halas, Naomi J.

doi:10.1021/nl060865w

Cited by 329 publications

(320 citation statements)

References 32 publications

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“…Qualitative pH determination still find different applications also in the era when pH tester at nanometric level are developed (Bishnoi et al 2006). It is suspected that the pH paper is first invented in the early 1800s by a French chemist named J.L.…”

Section: Most Common Methods For Ph Testingmentioning

confidence: 99%

pH and CO2 Sensing by Curcumin-Coloured Cellophane Test Strip

2015

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2 pH and CO 2 sensing by curcumin coloured cellophane test strip ABSTRACTCurcumin coloured cellophane test strip -fabricated without any synthetic material -is used to determine in situ the instantaneous pH changes in liquids and in the air. A low cost, portable sensor array for possible medical and food-industrial application is developed. Next to the pH detection, curcumin coloured test strip can be applied as CO 2 monitoring sensor, too. On-going processes and the structural changes are followed by UV-VIS spectrophotometer, ATR-FTIR and AFM.

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Section: Most Common Methods For Ph Testingmentioning

confidence: 99%

pH and CO2 Sensing by Curcumin-Coloured Cellophane Test Strip

2015

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“…This response is a result of biological, chemical, mechanical or electrical reactions occurring on the sensor. Examples of nanobiosensors are quantum dots, fluorescent nanoparticles, metallic nanoparticles, CNs [41], pH sensors or oxygen sensors that use nanotechnology for locally discrete measurements or a molecule-release sensor (such as release of calcium or potassium) [46]. Energy supply of nanosensors can be provided through the integration of motor proteins that function through ATP [47].…”

Section: Carbon Nanotubesmentioning

confidence: 99%

Nanotechnology in regenerative medicine: the materials side

Engel

Michiardi

Navarro

et al. 2008

Trends in Biotechnology

294

205

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“…Nanosensors to measure intracellular pH have been reported in many studies, the most common being 4-mercaptobenzoic acid functionalised nanoparticles. [84][85][86][87] Auchinvole et al [88] also developed nanosensors for measurement of intracellular redox potential, a key physiological characteristic, with changes in redox potential often associated with disease development. This is therefore a key characteristic that could be monitored in HTS assays to monitor response to drug treatment.…”

Section: An Alternative Technique -Surface Enhanced Raman Spectroscopmentioning

confidence: 99%

Vibrational spectroscopy as a tool for studying drug-cell interaction: Could high throughput vibrational spectroscopic screening improve drug development?

Jamieson

Byrne²

2017

Vibrational Spectroscopy

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. (2017). Vibrational spectroscopy as a tool for studying drug-cell interaction: could high throughput vibrational spectroscopic screening improve drug development? Vibrational Spectroscopy, vol. 91, July, pp. 16-30. doi.org/10.1016/ j.vibspec.2016 Vibrational spectroscopy as a tool for studying drug-cell interaction: could high throughput vibrational spectroscopic screening improve drug development? AbstractVibrational spectroscopy is currently widely explored as a tool in biomedical applications. An area at the forefront of this field is the use of vibrational spectroscopy for disease diagnosis, ultimately aiming towards spectral pathology. However, while this field shows promising results, moving this technique into the clinic faces the challenges of widespread clinical trials and legislative approval. While spectral pathology has received a lot of attention, there are many other biomedical applications of vibrational spectroscopy, which could potentially be translated to applications with greater ease. A particularly promising application is the use of vibrational spectroscopic techniques to study the interaction of drugs with cells. Many studies have demonstrated the ability to detect biochemical changes in cells in response to drug application, using both infrared and Raman spectroscopy. This has shown potential for use in high throughput screening (HTS) applications, for screening of efficacy and mode of action of potential drug candidates, to speed up the drug discovery process. HTS is still a relatively new and growing area of research and, therefore, there is more potential for new techniques to move into and shape this field. Vibrational spectroscopic techniques come with many benefits over the techniques used currently in HTS, primarily based on fluorescence assays to detect specific binding interactions or phenotypes. They are label free, and an infrared or Raman spectrum provides a wealth of biochemical information, and therefore could reveal not only information about a specific interaction, but about how the overall biochemistry of a cell changes in response to application of a drug candidate. Therefore, drug mode of action could be elucidated. This review will investigate the potential for vibrational spectroscopy, particularly FTIR and Raman spectroscopy, to benefit the field of HTS and improve the drug development process. In addition to FTIR and Raman spectroscopy, surface enhanced Raman spectroscopy (SERS), coherent anti-Stokes Raman spectroscopy (CARS) and stimulated Raman spectroscopy (SRS), will be investigated as an alternative tool in the HTS process.

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All-Optical Nanoscale pH Meter

Cited by 329 publications

References 32 publications

pH and CO2 Sensing by Curcumin-Coloured Cellophane Test Strip

pH and CO2 Sensing by Curcumin-Coloured Cellophane Test Strip

Nanotechnology in regenerative medicine: the materials side

Vibrational spectroscopy as a tool for studying drug-cell interaction: Could high throughput vibrational spectroscopic screening improve drug development?

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