All-in-one mitochondria-targeted NIR-II fluorophores for cancer therapy and imaging

Yang, Zheng; Li, Qianqian; Wu, Jing; 羅, 志偉; Zhou, Wenyi; Li, Anguo; Chen, Yanling; Rouzi, Tuerxunayi; Tian, Tian; Zhou, Hui; Zeng, Xiaodong; Yang, Li; Cheng, Xiaoding; Wei, Yongchang; Deng, Zixin; Zhou, Fuling; Hong, Xuechuan

doi:10.1039/d0sc04727a

Cited by 65 publications

(51 citation statements)

References 71 publications

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“…The donor-acceptor-donor (D-A-D) architecture based on a BBTD core, has been previously used to successfully construct small molecule-based NIR-II fluorophores. 50 However, these NIR-II πelectron conjugated luminophores are easily prone to aggregation-caused quenching (ACQ) in the aggregation state, in which subsequently suppresses fluorescence emission during bioimaging. [51][52][53] In the present study, we optimized QYs of small molecule-based NIR-II imaging agents, with the aim of extending the emission wavelength of AIEgens in the NIR-IIb region.…”

Section: Resultsmentioning

confidence: 99%

Small-Molecule Fluorophores for Near-Infrared IIb Imaging and Image-Guided Therapy of Vascular Diseases

et al. 2022

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Accurate and dynamic visualization of vascular diseases can contribute to restraining the further deterioration of diseases in a timely manner. However, it is still unable to precisely determine whether and to what extent blood vessels or brain tissues are damaged. Here we report novel BBTD-based NIR-II fluorophores HY1-HY4 with highly twisted structures (55 o at the S 0 state), extremely strong aggregation-induced emission (AIE) characteristics (I/I 0 > 13), and remarkably high fluorescence QYs (up to 14.45%) in the NIR-II region (> 1000 nm) and ~ 0.27% in the NIR-IIb window (> 1500 nm) in aqueous solution. Using NIR-IIb AIE HY4 dots, high-resolution NIR-IIb fluorescence imaging of revascularization and thrombolysis, and real-time feedback of the therapeutic efficacy of Chinese medicine DXI on ischemic stroke, were achievedfor the first time. In addition, results showed that DXI conferred neuroprotection against cerebral ischemia injury mediated via the angiogenesis pathway. These attractive results provide a new perspective for designing ultra-bright NIR-IIb probes for the vascular-related phenomena, disease assessment, and precise intraoperative imageguided therapy with a deeper tissue penetration depth and higher resolution.

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Section: Resultsmentioning

confidence: 99%

Small-Molecule Fluorophores for Near-Infrared IIb Imaging and Image-Guided Therapy of Vascular Diseases

et al. 2022

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“…In addition, H4‐PEG‐Glu demonstrated a highly synergistic chemotherapeutic photothermal effect in vivo, and was the first to specifically image tumors in AML patient‐derived PDX mouse models. [ 57 ]…”

Section: Nir‐ii Fluorescence Imagingmentioning

confidence: 99%

“…In addition, H4-PEG-Glu demonstrated a highly synergistic chemotherapeutic photothermal effect in vivo, and was the first to specifically image tumors in AML patientderived PDX mouse models. [57] In addition, the dyes used for NIR-II imaging include IR-FE and Q4, which have similar structural systems. As shown in Figure 9a ) Chemical structure of CH1055 and the one-step sulfonation to produce CH-4T.…”

Section: Organic Fluorescent Moleculesmentioning

confidence: 99%

Near‐Infrared‐II Nanomaterials for Fluorescence Imaging and Photodynamic Therapy

Lin

Zheng

et al. 2021

Advanced Optical Materials

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Fluorescence (FL) imaging and photodynamic therapy (PDT) are popular in the diagnosis and treatment of diseases, respectively, especially in cancer. The excitation of the laser in the second near‐infrared (NIR‐II) window can effectively avoid the interference of spontaneous fluorescence and light scattering of tissues, obtaining high‐resolution images at deeper penetration depth. Due to their ideal spectral absorbance and high conversion efficiency, nanomaterials with emission at NIR‐II window not only overcome the absorption or emission of NIR‐II light by endogenous biomolecules, but also facilitate NIR‐II FL imaging and the application of photodynamic therapy (PDT). The research progress of NIR‐II nanomaterials for FL imaging and PDT in recent years is reviewed. First, the NIR‐II FL imaging of several representative organic and inorganic materials is introduced, including their remarkable properties and synthesis methods. Then, the use of NIR‐II nanomaterials in PDT, such as NIR‐II FL imaging‐guided PDT, and PDT combined with photothermal therapy is described. Finally, some critical challenges and open problems are proposed that need to be addressed in synthetic technology and clinical application.

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“…One modality that appears attractive for combination with deferasirox is photothermal therapy (PTT), which relies on photonic energy to generate local hyperthermia to damage cancer cells [ [22] , [23] , [24] ]. PTT takes advantage of the susceptibility of cancer cells toward heat to induce apoptosis [ 25 , 26 ]. Especially, because of its O 2 -independent mechanism of action, PTT has emerged as an important strategy for improving the sensibility of conventional cancer treatments, such as radio- and chemotherapy [ [27] , [28] , [29] , [30] ].…”

Section: Introductionmentioning

confidence: 99%

2D-ultrathin MXene/DOXjade platform for iron chelation chemo-photothermal therapy

Wang

et al. 2022

Bioactive Materials

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All-in-one mitochondria-targeted NIR-II fluorophores for cancer therapy and imaging

Abstract: Small-molecule subcellular organelle-targeting theranostics are crucial for early disease diagnosis and treatment. The imaging window of these molecules are mainly focused on visible and near infrared (below ~ 900 nm)...

Cited by 65 publications

References 71 publications

Small-Molecule Fluorophores for Near-Infrared IIb Imaging and Image-Guided Therapy of Vascular Diseases

Small-Molecule Fluorophores for Near-Infrared IIb Imaging and Image-Guided Therapy of Vascular Diseases

Near‐Infrared‐II Nanomaterials for Fluorescence Imaging and Photodynamic Therapy

2D-ultrathin MXene/DOXjade platform for iron chelation chemo-photothermal therapy

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