2D-ultrathin MXene/DOXjade platform for iron chelation chemo-photothermal therapy

Xu, Yunjie; Wang, Yingwei; An, Jusung; Sedgwick, Adam; Li, Mingle; Xie, Jianlei; Hu, Weibin; Kang, Jianlong; Sen, Sajal; Steinbrueck, Axel; Zhang, Bin; Qiao, Liang; Wageh, S.; Arambula, Jonathan F.; Liu, Liping; Zhang, Han; Sessler, Jonathan L.; Kim, Jong Seung

doi:10.1016/j.bioactmat.2021.12.011

Cited by 50 publications

(43 citation statements)

References 52 publications

(61 reference statements)

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“…Therefore, nonenzymatic antioxidant nanomaterials with broad-spectrum free-radical scavenging capacity and better biocompatibility are proposed to reduce oxidative stress damage without significant side effects. MXene, a two-dimensional (2D) material with ultrathin layer-structured topology, has attracted increasing attention in biomedical applications due to its large surface area, fascinating biocompatibility, and excellent photothermal conversion ability. − More importantly, 2D Ti 3 C 2 MXene nanosheets exhibit broad-spectrum redox-mediated ROS scavenging activities against various ROS including hydrogen peroxide (H 2 O 2 ), hydroxyl radical ( • OH), and superoxide anion (O 2 •– ) to alleviate oxidative stress-induced damage as a nonenzymatic antioxidant nanoplatform, , yet it has rarely been studied. Additionally, MXene presents high antibacterial activity toward both Gram-negative Escherichia coli ( E. coli ) and Gram-positive Staphylococcus aureus ( S. aureus ), showing the ability to eradicate bacteria effectively and prevent infection for diabetic wound repair.…”

Section: Introductionmentioning

confidence: 99%

Artificial Nonenzymatic Antioxidant MXene Nanosheet-Anchored Injectable Hydrogel as a Mild Photothermal-Controlled Oxygen Release Platform for Diabetic Wound Healing

et al. 2022

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Hypoxia, excessive reactive oxygen species (ROS), impaired angiogenesis, lasting inflammation, and bacterial infection, are key problems impeding diabetic wound healing. Particularly, controllable oxygen release and ROS scavenging capacities are critical during the wound healing process. Here, an injectable hydrogel based on hyaluronic acid-graft-dopamine (HA-DA) and polydopamine (PDA) coated Ti3C2 MXene nanosheets is developed catalytically cross-linked by an oxyhemoglobin/hydrogen (HbO2/H2O2) system combined with mild photothermal stimulation for diabetic wound healing. HbO2 not only acts as a horseradish peroxidase-like to catalyze the hydrogel formation but also as an oxygen carrier to controllably release oxygen when activated by the mild heat produced from near-infrared (NIR) irradiation. Specifically, HbO2 can provide oxygen repeatedly by binding oxygen in the air when the NIR is off. The stable photoresponsive heating behavior of MXene ensures the repeatable oxygen release. Additionally, artificial nonenzymatic antioxidant MXene nanosheets are proposed to scavenge excessive reactive nitrogen species and ROS including H2O2, O2 •–, and •OH, keeping the intracellular redox homeostasis and alleviating oxidative stress, and eradicate bacteria to avoid infection. The antioxidant and antibacterial abilities of MXene are further improved by PDA coating, which also promotes the MXene nanosheets cross-linking into the network of the hydrogel. HA-DA molecules endow the hydrogel with the capacity to regulate macrophage polarization from M1 to M2 to achieve anti-inflammation. More importantly, the MXene-anchored hydrogel with multifunctions including tissue adhesion, self-healing, injectability, and hemostasis, combined with mild photothermal stimulation, greatly promotes human umbilical vein endothelial cell proliferation and migration and notably facilitates infected diabetic wound healing.

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Section: Introductionmentioning

confidence: 99%

Artificial Nonenzymatic Antioxidant MXene Nanosheet-Anchored Injectable Hydrogel as a Mild Photothermal-Controlled Oxygen Release Platform for Diabetic Wound Healing

et al. 2022

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“…Ti 3 C 2 T x films absorbed light in the UV–Vis ranges from 300 to 500 nm wavelength and had a transmittance of up to 91.2 percent at 5 nm thickness [ 173 , 174 ]. In addition, depending on the film thicknesses, it may have a strong absorption band at roughly 700–800 nm, which causes pale greenish film color [ 172 ] and is important for photothermal diseases (PTT) treatment [ 175 – 177 ]. It is worth noting that the transmittance values could be improved by adjusting the thickness [ 178 ] and ion intercalation [ 174 ].…”

Section: Mxene: Synthesis and Propertiesmentioning

confidence: 99%

Next-Generation Intelligent MXene-Based Electrochemical Aptasensors for Point-of-Care Cancer Diagnostics

et al. 2022

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Delayed diagnosis of cancer using conventional diagnostic modalities needs to be addressed to reduce the mortality rate of cancer. Recently, 2D nanomaterial-enabled advanced biosensors have shown potential towards the early diagnosis of cancer. The high surface area, surface functional groups availability, and excellent electrical conductivity of MXene make it the 2D material of choice for the fabrication of advanced electrochemical biosensors for disease diagnostics. MXene-enabled electrochemical aptasensors have shown great promise for the detection of cancer biomarkers with a femtomolar limit of detection. Additionally, the stability, ease of synthesis, good reproducibility, and high specificity offered by MXene-enabled aptasensors hold promise to be the mainstream diagnostic approach. In this review, the design and fabrication of MXene-based electrochemical aptasensors for the detection of cancer biomarkers have been discussed. Besides, various synthetic processes and useful properties of MXenes which can be tuned and optimized easily and efficiently to fabricate sensitive biosensors have been elucidated. Further, futuristic sensing applications along with challenges will be deliberated herein.

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“…-The tumor growth inhibition effect was observed. [113] Carbon dot@Ti 3 C 2 T x heterojunctions Breast SDT/PTT -The photothermal conversion efficiency in the NIR-II bio-window was enhanced by 64.5%. -The complete tumor ablation was occurred due to the enhancement of ROS generation efficiency (3.07 times more than that of commercial TiO 2 nanoparticles) as well as the mild NIR-II PTT-enhanced deep tissue SDT.…”

Section: Cancer Diagnosis and Therapymentioning

confidence: 99%

Biomedical Applications of MXene‐Integrated Composites: Regenerative Medicine, Infection Therapy, Cancer Treatment, and Biosensing

Maleki

Ghomi

Nikfarjam

et al. 2022

Adv Funct Materials

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MXenes (viz., transition metal carbides, carbonitrides, and nitrides) have emerged as a new subclass of 2D materials. Due to their outstanding physicochemical and biological properties, MXenes have gained much attention in the biomedical field in recent years, including drug delivery systems, regenerative medicine, and biosensing. Additionally, the incorporation of MXenes into hydrogels has garnered significant interest in biomedical engineering as an electroactive and mechanical nanoreinforcer capable of converting nonconductive scaffolds into excellent conductors of electricity with an impressive effect on mechanical properties for the engineering of electroactive organs and tissues such as cardiac, skeletal muscle, and nerve. However, many questions and problems remain unresolved that need to be answered to usher these 2D materials toward their true destiny. Thus, this review paper aims to provide an overview of the design and applications of MXene-integrated composites for biomedical applications, including cardiac tissue engineering, wound healing, infection therapy, cancer therapy, and biosensors. Moreover, the current challenges and limitations of utilizing MXenes in vivo are highlighted and discussed, followed by its prospects as a guideline toward possible various futuristic biomedical applications. This review article will inspire researchers, who search for properties, opportunities, and challenges of using this 2D nanomaterial in biomedical applications.

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2D-ultrathin MXene/DOXjade platform for iron chelation chemo-photothermal therapy

Cited by 50 publications

References 52 publications

Artificial Nonenzymatic Antioxidant MXene Nanosheet-Anchored Injectable Hydrogel as a Mild Photothermal-Controlled Oxygen Release Platform for Diabetic Wound Healing

Artificial Nonenzymatic Antioxidant MXene Nanosheet-Anchored Injectable Hydrogel as a Mild Photothermal-Controlled Oxygen Release Platform for Diabetic Wound Healing

Next-Generation Intelligent MXene-Based Electrochemical Aptasensors for Point-of-Care Cancer Diagnostics

Biomedical Applications of MXene‐Integrated Composites: Regenerative Medicine, Infection Therapy, Cancer Treatment, and Biosensing

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