Alkaloids fromFumaria parvifloraandF. kralikii*

Abstract

From Fumaria parviflora Lam. were isolated the major alkaloids protopine and adlumidiceine and the minor alkaloids parfumine, fumariline, dihydrofumariline, cryptopine, (-)-stylopine, 8-oxocoptisine, sanguinarine, and oxysanguinarine. The quaternary protoberberine fraction gave coptisine. Adlumidiceine, dihydrofumariline, 8-oxocoptisine, sanguinarine, and oxysanguinarine were found in F. parviflora for the first time. F. kralikii Jordan gave, besides the major alkaloids protopine, fumarophycine, and O-methylfumarophycine, the alkaloids adlumidiceine, berberine, coptisine, cryptopine, (-)-stylopine, and (-)-canadine. Only protopine and cryptopine have been isolated from F. kralikii earlier.

Mechanisms underlying the antidiarrheal, antispasmodic and bronchodilator activities of Fumaria parviflora and involvement of tissue and species specificity

“…Phytochemical studies on Fumaria parviflora have shown the presence of alkaloids, such as, adlumidiceine, coptisine, fumariline, parfumine, protopine (Popova et al, 1982), fumaranine, fumaritine, paprafumicin, paprarine (Atta-ur-Rahman et al, 1992), fumarophycine, cryptopine, sanactine, stylopine, bicuculline, adlumine, perfumidine and dihydrosanguirine (Suau et al, 2002).…”

Pharmacological basis for the use of Fumaria indica in constipation and diarrhea

“…Phytochemical investigation revealed the presence of several alkaloids such as adlumidiceine, copticine, fumariline, perfumine, protopine (Popova et al, 1982), fumaranine, fumaritine, paprafumicin and paprarine (Rahman et al, 1992). The plant has also been evaluated pharmacologically and shown to possess anthelmintic (Hordgen et al, 2003), antipyretic (Khattak et al, 1985), hepatoprotective (Gilani et al, 1996) and hypoglycemic (Akhtar et al, 1984) properties.…”

Effects of Fumaria parviflora L on Uremic Pruritus in Hemodialysis Patients: A Randomized, Double-Blind, Placebo-Controlled Trial

“…This medicinal plant contains several alkaloids and organic acids. Fumaric acid is one of its most efficacious components (25,26). Moreover, FP contains fumaric acid esters (FAEs) in addition to monomethylfumarate (MMF), the most bioactive metabolite of FAEs (24,27).…”