Mechanisms underlying the antidiarrheal, antispasmodic and bronchodilator activities of Fumaria parviflora and involvement of tissue and species specificity

Rehman, Najeeb Ur; Bashir, Samra; Al‐Rehaily, Adnan J.; Gilani, Anwarul Hassan

doi:10.1016/j.jep.2012.08.039

Cited by 24 publications

(10 citation statements)

References 34 publications

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“…F. parviflora has traditionally been used in Saudi folk medicine for the treatment of jaundice and hepatobiliary disorders (29). At day 5 post-treatment, hexane and methanol extracts of F. parviflora showed the best anti-HBV activities by ~37.45 and 46.86%, respectively.…”

Section: Discussionmentioning

confidence: 99%

In vitro evaluation of novel antiviral activities of 60 medicinal plants extracts against hepatitis B virus

Arbab

Parvez

Al‐Dosari

et al. 2017

Experimental and Therapeutic Medicine

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Currently, >35 Saudi Arabian medicinal plants are traditionally used for various liver disorders without a scientific rationale. This is the first experimental evaluation of the anti-hepatitis B virus (HBV) potential of the total ethanolic and sequential organic extracts of 60 candidate medicinal plants. The extracts were tested for toxicity on HepG2.2.15 cells and cytotoxicity concentration (CC50) values were determined. The extracts were further investigated on HepG2.2.15 cells for anti-HBV activities by analyzing the inhibition of HBsAg and HBeAg production in the culture supernatants, and their half maximal inhibitory concentration (IC50) and therapeutic index (TI) values were determined. Of the screened plants, Guiera senegalensis (dichloromethane extract, IC50=10.65), Pulicaria crispa (ethyl acetate extract, IC50=14.45), Coccinea grandis (total ethanol extract, IC50=31.57), Fumaria parviflora (hexane extract, IC50=35.44), Capparis decidua (aqueous extract, IC50=66.82), Corallocarpus epigeus (total ethanol extract, IC50=71.9), Indigofera caerulea (methanol extract, IC50=73.21), Abutilon figarianum (dichloromethane extract, IC50=99.76) and Acacia oerfota (total ethanol extract, IC50=101.46) demonstrated novel anti-HBV activities in a time- and dose-dependent manner. Further qualitative phytochemical analysis of the active extracts revealed the presence of alkaloids, tannins, flavonoids and saponins, which are attributed to antiviral efficacies. In conclusion, P. crispa, G. senegalensis and F. parviflora had the most promising anti-HBV potentials, including those of C. decidua, C. epigeus, A. figarianum, A. oerfota and I. caerulea with marked activities. However, a detailed phytochemical study of these extracts is essential to isolate the active principle(s) responsible for their novel anti-HBV potential.

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Section: Discussionmentioning

confidence: 99%

In vitro evaluation of novel antiviral activities of 60 medicinal plants extracts against hepatitis B virus

Arbab

Parvez

Al‐Dosari

et al. 2017

Experimental and Therapeutic Medicine

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“…[ 23 ]. The most frequently cited activities for these species are the antioxidant ones while several studies describe the antidiarrheal, antispasmodic, and bronchodilator activities [ 24 ]. Compounds that are responsible for these activities are polyphenols and flavonoids, found in important amounts especially in the aerial parts of these species [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Polyphenolic Content, Antioxidant and Diuretic Activities of Six Fumaria Species

et al. 2017

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Romanian traditional medicine describes the use of aerial parts of Fumaria species to treat hepatobiliary diseases as well as diuretic agents. The present study aims to investigate the chemical composition, antioxidant properties, and diuretic effects of several Fumaria species. LC/MS analysis revealed that Fumaria species contain phenolic acids and high amounts of flavonoids with rutin and isoquercitrin as main compounds. Concerning antioxidant capacity, the most significant results were obtained for F. capreolata and F. vailantii. Both species showed a good correlation between the antioxidant capacity and a high amount of flavonoids. Furthermore, the extracts of F. officinalis and F. schleicheri produced a strong increase in urinary volumetric excretion of saline-loaded rats, 24 h after the oral administration of a single dose of 250 mg/kg bw. Moreover, both extracts of F. officinalis and F. schleicheri increased the urinary excretion of Na+ and K+. Results from the present study offer a new perspective concerning the chemical composition and bioactivities of traditionally used fumitory species.

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“…Antidiarrheal activity of Aa.Cr was studied on castor oil‐induced diarrhea in mice following a method used previously (Najeeb‐ur‐Rehman et al ., ; Abdur‐Rahman et al ., ). Thirty‐five mice of equal body weight were randomly divided into seven groups of five animals each.…”

Section: Methodsmentioning

confidence: 99%

Pharmacological Evaluation of Gut Modulatory and Bronchodilator Activities of Achyranthes aspera Linn.

Rahman

Bashir

Mandukhail

et al. 2017

Phytotherapy Research

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Achyranthes aspera L. is traditionally used to relieve constipation, diarrhea, and asthma. Its crude extract (Aa.Cr) was evaluated through in vivo and ex vivo experiments to rationalize these medicinal uses of A. aspera and to provide their scientific basis. Aa.Cr, at 3 and 10 mg/kg, increased fecal output, similar to castor oil, whereas at 30, 100, 300, and 700 mg/kg, it protected against castor oil-induced diarrhea in mice when administered orally. Aa.Cr caused spasmogenic effect on rabbit jejunum and guinea pig ileum preparations, which was partially inhibited by atropine while completely blocked by cyproheptadine preincubation. Aa.Cr also relaxed high K (80 mM)-induced contraction in rabbit jejunum. Aa.Cr inhibited CCh (100 μg/kg)-induced bronchospasm in rats, similar to aminophylline. Like dicyclomine, Aa.Cr relaxed high K and CCh (1 μM)-induced contractions in guinea pig trachea and caused rightwards parallel shift of CCh concentration-response curves at the lower concentrations followed by non-parallel shift at the higher concentrations. On activity-directed fractionation, spasmogenic and spasmolytic activities of Aa.Cr were concentrated in aqueous and organic fraction, respectively. This study suggests the presence of dose-specific laxative and antidiarrheal effects in A. aspera, possibly mediated through cyproheptadine-sensitive receptors and dual cholinergic and calcium channel blockade, respectively. The latter combination is also a suggested mechanism underlying its bronchodilator effect. Copyright © 2017 John Wiley & Sons, Ltd.

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Mechanisms underlying the antidiarrheal, antispasmodic and bronchodilator activities of Fumaria parviflora and involvement of tissue and species specificity

Cited by 24 publications

References 34 publications

In vitro evaluation of novel antiviral activities of 60 medicinal plants extracts against hepatitis B virus

In vitro evaluation of novel antiviral activities of 60 medicinal plants extracts against hepatitis B virus

Evaluation of Polyphenolic Content, Antioxidant and Diuretic Activities of Six Fumaria Species

Pharmacological Evaluation of Gut Modulatory and Bronchodilator Activities of Achyranthes aspera Linn.

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