Evaluation of Polyphenolic Content, Antioxidant and Diuretic Activities of Six Fumaria Species

Păltinean, Ramona; Mocan, Andrei; Vlase, Laurian; Gheldiu, Ana-Maria; Crișan, Gianina; Ielciu, Irina; Voștinaru, Oliviu; Crisan, O.

doi:10.3390/molecules22040639

Cited by 46 publications

(55 citation statements)

References 30 publications

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“…Significantly lower concentrations of these compounds were determined in vinegars made of grape—26 mg GAE/100 mL [ 36 ] or hawthorn—28 mg GAE/100 mL [ 26 ]. Considerable differences observed between results obtained in our study and findings of other authors may be due to the fact that the concentration of polyphenolics in vinegars depends most of all on the type of raw material as well as on their production process including: duration and conditions of fermentation and conditions of ageing [ 36 , 37 ]. The content of total polyphenolics in fruits of Cornelian cherry expressed as gallic acid equivalents ranges from 209 to 811 mg GAE/100 g [ 38 , 39 , 40 ].…”

Section: Discussioncontrasting

confidence: 90%

Bioactive Compounds in Cornelian Cherry Vinegars

Kawa-Rygielska¹,

Adamenko²,

Kucharska

et al. 2018

Molecules

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We analyzed the effect of Cornelian cherry varieties differing in fruit color (‘Yantaryi’—yellow fruits, ‘Koralovyi’—coral fruits, ‘Podolski’—red fruits) and the production method on the physicochemical and antioxidative properties of Cornelian cherry vinegars, and on their content of iridoids and polyphenols. Acetic fermentation was conducted by two methods: I) single-stage (spontaneous) acetic fermentation, without inoculation with microorganisms, and II) two-stage fermentation in which the first stage involved the use of Saccharomyces bayanus—Safspirit fruit yeast for alcoholic fermentation, and the second one included spontaneous acetic fermentation. Acetic acid, glycerol, individual iridoids, phenolic acids, flavonols, and anthocyanins were quantified by a high-performance liquid chromatography (HPLC) method. The antioxidative activity was determined based on the following tests: 2,2-Diphenyl-2-picryl-hydrazyl (DPPH•), 2,2′-Azino-bis(3-ethylbenzo-thiazoline-6-sulfonic acid (ABTS•+), and ferric reducing antioxidant power (FRAP), while the total polyphenols content was determined using the Folin-Ciocialteu (F-C) reagent test. Both the Cornelian cherry variety and vinegar production method affected the antioxidative properties as well as concentrations of iridoids and polyphenols in the finished product. The concentration of total polyphenols (F-C) in vinegars ranged from 326.60 to 757.27 mg gallic acids equivalents (GAE)/100 mL vinegar, whereas the antioxidative activity assayed with the DPPH• and FRAP methods was the highest in the vinegars produced from the coral and red varieties of Cornelian cherry with the two-stage method. Loganic acid predominated among the identified iridoids, reaching a concentration of 185.07 mg loganic acid (LA)/100 mL in the vinegar produced in the two-stage fermentation from the coral-fruit variety. Caffeoylquinic acid derivatives were the main representatives among the identified phenolic compounds. The results of this study demonstrate Cornelian cherry vinegars to be rich sources of biologically-active iridoids and phenolic compounds with antioxidative properties.

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Section: Discussioncontrasting

confidence: 90%

Bioactive Compounds in Cornelian Cherry Vinegars

Kawa-Rygielska¹,

Adamenko²,

Kucharska

et al. 2018

Molecules

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“…Qualitative and quantitative evaluation of phenolic compounds in the composition of the methanolic (MeOH), ethanolic (EtOH) and 70% ( v / v ) ethanolic (EtOH 70%) extracts obtained from the flowers of A. dioica and H. arenarium was achieved using an HPLC-MS method. The method was previously applied for the phytochemical analysis of different plant samples and provided good results [ 25 , 26 ]. Each sample was analyzed before and after acid hydrolysis in order to obtain more accurate data on the composition in flavonoid glycosides and their aglycones [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

“…The HPLC system was coupled with an Agilent 1100 mass spectrometer (LC/MSD Ion Trap VL). The chromatographic data were processed using ChemStation and DataAnalysis software from Agilent [ 25 , 32 , 33 , 34 ].…”

Section: Methodsmentioning

confidence: 99%

Phytochemical Analysis, Antioxidant and Antimicrobial Activities of Helichrysum arenarium (L.) Moench. and Antennaria dioica (L.) Gaertn. Flowers

et al. 2018

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Antennaria dioica (L.) Gaertn. and Helichrysum arenarium (L.) Moench. are two species of the Asteraceae family, known in Romanian traditional medicine for their diuretic, choleretic, and anti-inflammatory properties. The aim of the present study was to evaluate the phenolic and sterolic composition of flowers from the two species and to assess their antioxidant, antibacterial and antifungal properties. LC-MS analyses were performed on methanolic, ethanolic and 70% v/v ethanolic extracts, before and after acid hydrolysis, and revealed high amounts of polyphenols. Chlorogenic acid was found as the main compound for the flowers of A. dioica (502.70 ± 25.11 mg/100 g d.w.), while quercitrin was dominant in H. arenarium (424.28 ± 21.21 mg/100 g d.w.) in 70% v/v ethanolic extracts before hydrolysis. Antioxidant capacity assays showed an important antioxidant potential, which can be correlated with the determined polyphenolic compounds, showing the 70% v/v ethanolic extracts of the two species as being the most effective antioxidant samples for the DPPH assay. Antibacterial and antifungal assays confirm a modest biological potential for the same extract of both species. Results obtained in the present study bring important data and offer scientific evidence on the chemical composition and on the biological activities of the flowers belonging to the two species.

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“…The diuretic effect of orally administered TTE and TCC of AR on normal Sprague-Dawley rats was evaluated where their pharmacological responses were compared with those produced by HCTZ, a common diuretic in clinical practices, and their effects on electrolyte balance determined. According to previous diuretic pharmacology studies of herbal medicines [ 19 , 20 , 21 , 22 ], saline-loaded normal rats have been generally used to evaluate the diuretic effects of herbal medicines. Establishing a stable diuretic animal model is very important in uniformly designed experiments of TCC research, thus, a saline-loaded normal rat model was chosen.…”

Section: Discussionmentioning

confidence: 99%

Diuretic Activity of Compatible Triterpene Components of Alismatis rhizoma

Zhang

Lin

et al. 2017

Molecules

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Alismatis rhizoma (AR), the dried rhizoma of Alisma orientale Juzepzuk (Alismataceae), is a traditional Chinese medicine. AR is an important part of many prescriptions and is commonly used as a diuretic agent in Asia. This study aimed to evaluate the diuretic effects of total triterpene extract (TTE) and triterpene component compatibility (TCC, the mixture of alisol B 23-acetate, alisol B, alisol A 24-acetate, alisol A, and alisol C 23-acetate) of AR in saline-loaded rats. The optimal diuretic TCC of AR was optimized using a uniform design. Different doses (5, 20, and 40 mg/kg) of TTE and TCC groups (N1–N8) were orally administered to rats. Urinary excretion rate, pH, and electrolyte excretion were measured in the urine of saline-loaded rats. Results showed that TTE doses increased urine volume and electrolyte excretion compared with the control group. All uniformly designed groups of TCC also increased urine excretion. In addition, optimal diuretic TCC was calculated (alisol B 23-acetate: alisol B: alisol A 24-acetate: alisol A: alisol C 23-acetate 7.2:0.6:2.8:3.0:6.4) and further validated by saline-loaded rats. This study demonstrated that TTE presented a notable diuretic effect by increasing Na+, K+, and Cl− displacements. The most suitable TTC compatible proportion of alisol B 23-acetate: alisol B: alisol A 24-acetate: alisol A: alisol C 23-acetate for diuretic activity was validated, and triterpenes were the material basis for the diuretic activity of AR.

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Evaluation of Polyphenolic Content, Antioxidant and Diuretic Activities of Six Fumaria Species

Cited by 46 publications

References 30 publications

Bioactive Compounds in Cornelian Cherry Vinegars

Bioactive Compounds in Cornelian Cherry Vinegars

Phytochemical Analysis, Antioxidant and Antimicrobial Activities of Helichrysum arenarium (L.) Moench. and Antennaria dioica (L.) Gaertn. Flowers

Diuretic Activity of Compatible Triterpene Components of Alismatis rhizoma

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