Alkaloids and phenolics of Colchicum turcicum

Chemical constituents of the different parts ofColchicum baytopiorumand their cytotoxic activities on K562 and HL60 cell lines

“…Previous studies have indicated that the composition of tropolone alkaloids differs in different parts of Colchicum species and varies during the different growth stages (Sütlüpınar et al, 1988;Husek et al, 1990;Alali et al, 2006). The aim of the present work was to determine the chemical constituents of the different parts (perigon, perigon tube, leaf, seed, and corm) of C. baytopiorum, an unexplored Turkish species, as a continuation of our studies on Colchicum species (Baytop & Özcöbek, 1970;Baytop et al, 1980;Sütlüpınar, 2002).…”

“…Nine known alkaloids, namely, colchicine (1), 2-demethylcolchicine (2), 3-demethylcolchicine (3), 3-demethyl-N-formyl-N-deacetylcolchicine (4), colchifoline (5), 2-demethylcolchifoline (6), demecolcine (7), 2-demethyldemecolcine (8), and 2-demethyl--lumicolchicine (12), were isolated from the all separated parts of C. baytopiorum (Figure 1). The structures of the isolated compounds were elucidated using a series of spectrophotometric (UV, IR; 1 H-NMR, ESI-MS) methods by comparison of these spectral data with the literature (Fabian et al, 1955;Cross et al, 1965;Freyer et al, 1987;Husek et al, 1990;Abu-Zarga et al, 1991;Al-Tel et al, 1991) and TLC by comparison with authentic samples. The structures of three other alkaloids, namely, cornigerine (9), N-formyl-N-deacetylcolchicine (10), and 3-demethyldemecolcine (11) (Figure 1), were only determined by LC/MS/MS analysis (m/z values = 358, 386, 358, respectively).…”

Colchicum autumnale (suranjan): A cytotoxic plant with anti-arthritis properties

“…In Alali et al, 2007;Al-Fayyadet al, 2002;Khan et al, 20111970. Turhan Baytop and Gunay started the studies on Colchicum species and it has been continued by Nurhayat Sutlupinar (Baytop and Özcöbek, 1970;Husek et al, 1990;Sutlupinar, 1983). The studies on species have still Colchicum being worked by a group of pharma faculty, in Istanbul University, Turkey.…”

Colchicine: Isolation, LC–MS QTof Screening, and Anticancer Activity Study of Gloriosa superba Seeds

“…The higher content of colchicine in Gloriosa than in Colchicum makes it a commercially viable source of this medicine [9,10]. Several techniques have been developed to extract colchicine, and among these ‘soxhlet and solid–liquid extraction’ are the most commonly used [11,12]. Extraction of colchicine from C. autumnale using methanol [6], and from Gloriosa seeds by methanol [13] and ethanol [14] has also been reported.…”