Alginate–hyaluronan composite hydrogels accelerate wound healing process

Catanzano, Ovidio; D’Esposito, Vittoria; Acierno, Stefano; Ambrosio, Maria Rosaria; De, Carmen; Avagliano, Carmen; Russo, Pietro; Russo, R.; Miro, Agnese; Ungaro, Francesca; Calignano, Antonio; Formisano, Pietro; Quaglia, Fabiana

doi:10.1016/j.carbpol.2015.05.081

Cited by 123 publications

(79 citation statements)

References 43 publications

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“…It is already used in some commercially available advanced dressings such as Hyalofill® (Anika Therapeutics, Bedford Massachusetts), Hyalomatrix® (Anika Therapeutics), and Hyiodine® (Contipro Pharma, Dolni Dobrouc Czech Republic), which have demonstrated that the application of exogenous hyaluronic acid on wounds can exert positive effects on the wound‐healing process and pain management . Hyaluronic acid can be easily included within gauze, foams, or creams for topical use and has a high capacity to retain water and provides a moist environment to protect the wounded tissue surface from dryness and promotes wound healing …”

Section: Introductionmentioning

confidence: 99%

Advanced Therapeutic Dressings for Effective Wound Healing—A Review

Boateng

Catanzano

2015

Journal of Pharmaceutical Sciences

694

473

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Advanced therapeutic dressings that take active part in wound healing to achieve rapid and complete healing of chronic wounds is of current research interest. There is a desire for novel strategies to achieve expeditious wound healing due to the enormous financial burden worldwide. This paper reviews the current state of wound healing and wound management products, with emphasis on the demand for more advanced forms of wound therapy and some of the current challenges and driving forces behind this demand. The paper reviews information mainly from peer reviewed literature and other publicly available sources such as the FDA. A major focus is the treatment of chronic wounds including amputations, diabetic and leg ulcers, pressure sores, surgical and traumatic wounds (e.g. accidents and burns) where patient immunity is low and the risk of infections and complications are high. The main dressings include medicated moist dressings, tissue engineered substitutes, biomaterials based biological dressings, biological and naturally derived dressings, medicated sutures and various combinations of the above classes. Finally, the review briefly discusses possible prospects of advanced wound healing including some of the emerging approaches such as hyperbaric oxygen, negative pressure wound therapy and laser wound healing, in routine clinical care.3

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Section: Introductionmentioning

confidence: 99%

Advanced Therapeutic Dressings for Effective Wound Healing—A Review

Boateng

Catanzano

2015

Journal of Pharmaceutical Sciences

694

473

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“…Wound dressings play an important role in promoting wound healing and preventing infections post‐injury . Polysaccharides have been extensively used in development of wound dressings because of their desirable structural features as wound dressing materials . In particular, they are natural, highly abundant, biodegradable, and nontoxic.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Polysaccharides have been extensively used in development of wound dressings because of their desirable structural features as wound dressing materials. [3][4][5][6] In particular, they are natural, highly abundant, biodegradable, and nontoxic. They are an important class of biopolymers and play an important role in forming the extracellular matrix.…”

Section: Introductionmentioning

confidence: 99%

Fabrication, characterization, and in vitro evaluation of silver‐containing arabinoxylan foams as antimicrobial wound dressing

Aduba

Selders

et al. 2016

J Biomedical Materials Res

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Arabinoxylan ferulate (AXF) foams were fabricated via enzymatic peroxidase/hydrogen peroxide crosslinking reaction followed by freeze-drying and studied as a potential wound dressing material. The AXF foam’s rheological, morphological, porous and swelling properties were examined. AXF foams were found to be a viscoelastic material that proved to be highly porous and water absorbent. AXF foams possessed low endotoxin levels and were cytocompatible with fibroblasts. Silver was successfully integrated into AXF foams and slowly released over 48 hours. AXF foams impregnated with silver demonstrated efficacy inhibiting bacterial growth according to a modified Kirby-Bauer disk diffusion susceptibility test. Overall, AXF foams possess appropriate material properties and the silver-loaded AXF foams showed antimicrobial activity, necessary to be a candidate material in wound dressing development.

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“…This shows that NAG enters between the polymer chains and that the chain structure is looser than Alg. However, according to results obtained by Catanzano et al (2015), the amount of hyaluronic acid has a minimum effect on hydrogel swelling capacity.…”

Section: Swelling Analysis Of Hydrogelsmentioning

confidence: 91%

N-Acetylglucoseamine modified alginate sponges as scaffolds for skin tissue engineering

Demirbilek¹,

Türkoğlu²,

Aktürk³

2017

Turk J Biol

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In the treatment of dermal wounds, wound-dressing materials prepared from natural mucopolysaccharides are widely used because of their advantages such as nonirritation, nontoxicity, and ease in topical application. In the present study, alginate hydrogels modified with N-acetyl glucose amine (NAG) were prepared as wound-dressing material. Physical, chemical, thermal, and mechanical properties of the hydrogels were studied. Cytotoxicity of the hydrogels on endothelial (HUVEC) and keratinocyte (HaCaT) cells were examined. Anti-and proinflammatory cytokine levels of human monocyte-macrophage cells (THP-1) stimulated with hydrogels were determined. According to the results, increasing the NAG concentration led to an increase in the swelling and nitrogen ratios in the hydrogels. Additionally, increasing the NAG concentration decreased elastic modulus and degradation time. Hydrogels were not cytotoxic on HaCaT and HUVEC cells. It stimulated IL-10 and TNF-alpha levels at a small rate.

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Alginate–hyaluronan composite hydrogels accelerate wound healing process

Cited by 123 publications

References 43 publications

Advanced Therapeutic Dressings for Effective Wound Healing—A Review

Advanced Therapeutic Dressings for Effective Wound Healing—A Review

Fabrication, characterization, and in vitro evaluation of silver‐containing arabinoxylan foams as antimicrobial wound dressing

N-Acetylglucoseamine modified alginate sponges as scaffolds for skin tissue engineering

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