N-Acetylglucoseamine modified alginate sponges as scaffolds for skin tissue engineering

Demirbilek, Murat; Türkoğlu, Nelisa; Aktürk, Selçuk

doi:10.3906/biy-1704-31

Cited by 6 publications

(2 citation statements)

References 46 publications

(51 reference statements)

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“…The internal architecture of the obtained bilayer scaffold was compared with the internal architecture of an articular joint from rabbits, confirming the similarities in terms of microstructure [58]. In alginate-based spongelike structures, micro-CT was employed to evaluate the influence of the composition in the microarchitecture of the synthesized scaffolds in terms of open porosity [125]. Collagen scaffolds' features in both dry and hydrated states were investigated to understand the fluid flow and hydration mechanisms.…”

Section: Determination Of 3d Morphometric Parametersmentioning

confidence: 63%

Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications

et al. 2021

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The ever-growing field of materials with applications in the biomedical field holds great promise regarding the design and fabrication of devices with specific characteristics, especially scaffolds with personalized geometry and architecture. The continuous technological development pushes the limits of innovation in obtaining adequate scaffolds and establishing their characteristics and performance. To this end, computed tomography (CT) proved to be a reliable, nondestructive, high-performance machine, enabling visualization and structure analysis at submicronic resolutions. CT allows both qualitative and quantitative data of the 3D model, offering an overall image of its specific architectural features and reliable numerical data for rigorous analyses. The precise engineering of scaffolds consists in the fabrication of objects with well-defined morphometric parameters (e.g., shape, porosity, wall thickness) and in their performance validation through thorough control over their behavior (in situ visualization, degradation, new tissue formation, wear, etc.). This review is focused on the use of CT in biomaterial science with the aim of qualitatively and quantitatively assessing the scaffolds’ features and monitoring their behavior following in vivo or in vitro experiments. Furthermore, the paper presents the benefits and limitations regarding the employment of this technique when engineering materials with applications in the biomedical field.

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Section: Determination Of 3d Morphometric Parametersmentioning

confidence: 63%

Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications

et al. 2021

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“…The porous alginate scaffold enhanced macrophage immunological responses, but had no effect on shifting macrophages from one phenotype to the other. [ 107 ]…”

Section: Influence Of Different Polysaccharide‐based Substrates On Macrophagesmentioning

confidence: 99%

The Influence of Polysaccharides‐Based Material on Macrophage Phenotypes

Bratlie

2021

Macromolecular Bioscience

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Macrophage polarization is a key factor in determining the success of implanted tissue engineering scaffolds. Polysaccharides (derived from plants, animals, and microorganisms) are known to modulate macrophage phenotypes by recognizing cell membrane receptors. Numerous studies have developed polysaccharide‐based materials into functional biomaterial substrates for tissue regeneration and pharmaceutical application due to their immunostimulatory activities and anti‐inflammatory response. They are used as hydrogel substrates, surface coatings, and drug delivery carriers. In addition to their innate immunological functions, the newly endowed physical and chemical properties, including substrate modulus, pore size/porosity, surface binding chemistry, and the mole ratio of polysaccharides in hybrid materials may regulate macrophage phenotypes more precisely. Growing evidence indicates that the sulfation pattern of glycosaminoglycans and proteoglycans expressed on polarized macrophages leads to the changes in protein binding, which may alter macrophage phenotype and influence the immune response. A comprehensive understanding of how different types of polysaccharide‐based materials alter macrophage phenotypic changes can be beneficial to predict transplantation/implantation outcomes. This review focuses on recent advances in promoting wound healing and balancing macrophage phenotypes using polysaccharide‐based substrates/coatings and new directions to address the limitations in the current understanding of macrophage responses to polysaccharides.

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Glassy carbon electrode modified with carbon black and cross-linked alginate film: a new voltammetric electrode for paraquat determination

et al. 2019

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N-Acetylglucoseamine modified alginate sponges as scaffolds for skin tissue engineering

Cited by 6 publications

References 46 publications

Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications

Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications

The Influence of Polysaccharides‐Based Material on Macrophage Phenotypes

Glassy carbon electrode modified with carbon black and cross-linked alginate film: a new voltammetric electrode for paraquat determination

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